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SNHG1 small nucleolar RNA host gene 1 [ Homo sapiens (human) ]

Gene ID: 23642, updated on 16-Apr-2024

Summary

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Official Symbol
SNHG1provided by HGNC
Official Full Name
small nucleolar RNA host gene 1provided by HGNC
Primary source
HGNC:HGNC:32688
See related
Ensembl:ENSG00000255717 MIM:603222; AllianceGenome:HGNC:32688
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UHG; U22HG; lncRNA16; LINC00057; NCRNA00057
Summary
This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]
Expression
Broad expression in bone marrow (RPKM 85.9), ovary (RPKM 53.7) and 23 other tissues See more
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Genomic context

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See SNHG1 in Genome Data Viewer
Location:
11q12.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62851978..62855885, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62841372..62845280, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62619450..62623357, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4854 Neighboring gene STX5 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4859 Neighboring gene testis expressed 54 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3432 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62608631-62609244 Neighboring gene WD repeat domain 74 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62609245-62609858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62609859-62610472 Neighboring gene RNA, U2 small nuclear 2, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4862 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62621489-62622463 Neighboring gene small nucleolar RNA SNORD22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4863 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62623439-62624412 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62624413-62625388 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:62625389-62626362 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:62626363-62627337 Neighboring gene small nucleolar RNA, C/D box 22 Neighboring gene small nucleolar RNA, C/D box 31 Neighboring gene small nucleolar RNA, C/D box 30 Neighboring gene small nucleolar RNA, C/D box 29 Neighboring gene small nucleolar RNA, C/D box 28 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62628506-62629410 Neighboring gene small nucleolar RNA, C/D box 27 Neighboring gene small nucleolar RNA, C/D box 26 Neighboring gene small nucleolar RNA, C/D box 25 Neighboring gene solute carrier family 3 member 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:62634014-62634172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4865 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:62648644-62649843 Neighboring gene uncharacterized LOC124902683 Neighboring gene cholinergic receptor muscarinic 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human papillomavirus 16 E6 promotes angiogenesis of lung cancer via SNHG1. Nie Z, et al. Cell Biochem Biophys, 2023 Jun. PMID 36690880
  2. Role and Clinical Significance of LncRNA16 in the Malignant Proliferation of Lung Cancer Cells. Gu M, et al. Cell Mol Biol (Noisy-le-grand), 2022 Jul 31. PMID 36495499
  3. LncRNA SNHG1 targets miR-340-5p/PIK3CA axis to regulate microvascular endothelial cell proliferation, migration, and angiogenesis in DR. He FT, et al. Kaohsiung J Med Sci, 2023 Jan. PMID 36484399
  4. The SNHG1-Centered ceRNA Network Regulates Cell Cycle and Is a Potential Prognostic Biomarker for Hepatocellular Carcinoma. Zhou L, et al. Tohoku J Exp Med, 2022 Nov 11. PMID 36244757
  5. Long non-coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR-326/PKM2 axis. Wang Y, et al. J Gene Med, 2022 Aug. PMID 35816558

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA SNHG1 alleviates myocardial ischaemia-reperfusion injury by regulating the miR-137-3p/KLF4/TRPV1 axis.
    Title: LncRNA SNHG1 alleviates myocardial ischaemia-reperfusion injury by regulating the miR-137-3p/KLF4/TRPV1 axis.
  2. Long noncoding RNA SNHG1 promotes breast cancer progression by regulating the miR-641/RRS1 axis.
    Title: Long noncoding RNA SNHG1 promotes breast cancer progression by regulating the miR-641/RRS1 axis.
  3. SNHG1, interacting with SND1, contributes to sorafenib resistance of liver cancer cells by increasing m6A-mediated SLC7A11 expression and promoting aerobic glycolysis.
    Title: SNHG1, interacting with SND1, contributes to sorafenib resistance of liver cancer cells by increasing m6A-mediated SLC7A11 expression and promoting aerobic glycolysis.
  4. SNHG1/miR-21 axis mediates the cardioprotective role of aloin in sepsis through modulating cardiac cell viability and inflammatory responses.
    Title: SNHG1/miR-21 axis mediates the cardioprotective role of aloin in sepsis through modulating cardiac cell viability and inflammatory responses.
  5. METTL3 promotes proliferation and migration of colorectal cancer cells by increasing SNHG1 stability.
    Title: METTL3 promotes proliferation and migration of colorectal cancer cells by increasing SNHG1 stability.
  6. LncRNA-SNHG1 promotes paclitaxel resistance of gastric cancer cells through modulating the miR-216b-5p-hexokianse 2 axis.
    Title: LncRNA-SNHG1 promotes paclitaxel resistance of gastric cancer cells through modulating the miR-216b-5p-hexokianse 2 axis.
  7. LncRNA SNHG1 upregulates FANCD2 and G6PD to suppress ferroptosis by sponging miR-199a-5p/3p in hepatocellular carcinoma.
    Title: LncRNA SNHG1 upregulates FANCD2 and G6PD to suppress ferroptosis by sponging miR-199a-5p/3p in hepatocellular carcinoma.
  8. LncRNA SNHG1 promotes nasopharyngeal carcinoma development via targeting miR-424-5p.
    Title: LncRNA SNHG1 promotes nasopharyngeal carcinoma development via targeting miR-424-5p.
  9. SNHG1 functions as a ceRNA in hypertrophic scar fibroblast proliferation and apoptosis through miR-320b/CTNNB1 axis.
    Title: SNHG1 functions as a ceRNA in hypertrophic scar fibroblast proliferation and apoptosis through miR-320b/CTNNB1 axis.
  10. SNHG1, a KLF4-upregulated gene, promotes glioma cell survival and tumorigenesis under endoplasmic reticulum stress by upregulating BIRC3 expression.
    Title: SNHG1, a KLF4-upregulated gene, promotes glioma cell survival and tumorigenesis under endoplasmic reticulum stress by upregulating BIRC3 expression.
Submit: New GeneRIF Correction See all GeneRIFs (118)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • U22 snoRNA host
  • long intergenic non-protein coding RNA 57
  • small nucleolar RNA host gene 1 (non-protein coding)

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_003098.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, BC011809, DA856235
    Related
    ENST00000689147.1

  2. NR_152575.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, AK095849, BC011809, BC063571
    Related
    ENST00000658540.1

  3. NR_152576.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, AK095849, BC063571
    Related
    ENST00000537925.5

  4. NR_152577.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001160
    Related
    ENST00000686500.2

  5. NR_152578.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, AP001160, BC011809, BI828157
    Related
    ENST00000690542.1

  6. NR_152579.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, BC011809, BG493280

  7. NR_152580.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, BC011809, BG531729
    Related
    ENST00000686081.1

  8. NR_152581.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, BC011809, BM843108
    Related
    ENST00000539303.6

  9. NR_152582.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, AP001160, BC011809, CB145643

  10. NR_152583.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, AK095849, AP001160, BC011809, BM745869
    Related
    ENST00000689664.1

  11. NR_152584.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, AK095849, BC011809, BC063571, CN337018

  12. NR_152585.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA877654, AK095849, BC011809, BC063571, BG167802

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62851978..62855885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62841372..62845280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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