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Ifi209 interferon activated gene 209 [ Mus musculus (house mouse) ]

Gene ID: 236312, updated on 11-Apr-2024

Summary

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Official Symbol
Ifi209provided by MGI
Official Full Name
interferon activated gene 209provided by MGI
Primary source
MGI:MGI:2138243
See related
Ensembl:ENSMUSG00000043263 AllianceGenome:MGI:2138243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifix; Pyhin1; Pyhin-1; 4930422C14
Summary
Predicted to enable double-stranded DNA binding activity. Acts upstream of or within cellular response to interferon-beta. Predicted to be located in nucleus. Is expressed in embryo mesenchyme. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 3.3), liver E18 (RPKM 2.4) and 12 other tissues See more
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Genomic context

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Location:
1 H3; 1 80.54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173458425..173475494)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173630859..173647928)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interferon activated gene 214 Neighboring gene interferon activated gene 213 Neighboring gene STARR-positive B cell enhancer ABC_E11699 Neighboring gene STARR-seq mESC enhancer starr_03081 Neighboring gene STARR-positive B cell enhancer ABC_E10060 Neighboring gene STARR-positive B cell enhancer ABC_E5857 Neighboring gene STARR-positive B cell enhancer ABC_E4393 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175599072-175599372 Neighboring gene STARR-seq mESC enhancer starr_03083 Neighboring gene interferon activated gene 208 Neighboring gene pyrin and HIN domain family, member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse pyrin and HIN domain family member 1 (pyhin1) protein positively regulates LPS-induced IFN-β and NO production in macrophages. Haque A, et al. Innate Immun, 2014 Jan. PMID 23606517
  2. The mammalian PYHIN gene family: phylogeny, evolution and expression. Cridland JA, et al. BMC Evol Biol, 2012 Aug 7. PMID 22871040, Free PMC Article
  3. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. Brunette RL, et al. J Exp Med, 2012 Oct 22. PMID 23045604, Free PMC Article
  4. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Bürckstümmer T, et al. Nat Immunol, 2009 Mar. PMID 19158679
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. promotes LPS-induced IFN-beta and NO production in macrophages
    Title: Mouse pyrin and HIN domain family member 1 (pyhin1) protein positively regulates LPS-induced IFN-β and NO production in macrophages.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130358, MGC130359

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pyrin and HIN domain-containing protein 1
Names
ifi-209
interferon-inducible protein 209
interferon-inducible protein X
interferon-inducible protein p209
pyrin and HIN domain family, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175026.3 → NP_778191.1  pyrin and HIN domain-containing protein 1

    See identical proteins and their annotated locations for NP_778191.1

    Status: VALIDATED

    Source sequence(s)
    AC117682, AK080371, CJ056097
    Consensus CDS
    CCDS35791.1
    UniProtKB/Swiss-Prot
    Q3KNA6, Q3KNA7, Q3U1B4, Q504N7, Q8BLY5, Q8BV49, Q8BVS6
    UniProtKB/TrEMBL
    E9PVL3
    Related
    ENSMUSP00000061900.8, ENSMUST00000056071.13
    Conserved Domains (2) summary
    cd08305
    Location:10 → 82
    Pyrin; Pyrin: a protein-protein interaction domain
    pfam02760
    Location:231 → 396
    HIN; HIN-200/IF120x domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173458425..173475494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BV49.1 GenPept UniProtKB/Swiss-Prot:Q8BV49

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