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Zfp709 zinc finger protein 709 [ Mus musculus (house mouse) ]

Gene ID: 236193, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp709provided by MGI
Official Full Name
zinc finger protein 709provided by MGI
Primary source
MGI:MGI:2384299
See related
Ensembl:ENSMUSG00000056019 AllianceGenome:MGI:2384299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GIOT-4; HIT-40
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to heat; cellular response to lipopolysaccharide; and negative regulation of transcription by RNA polymerase II. Predicted to be located in plasma membrane. Is expressed in bladder; ureter; and urethra of female. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 1.1), placenta adult (RPKM 1.0) and 25 other tissues See more
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Genomic context

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Location:
8 B3.3; 8 34.57 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72635912..72646409)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71882068..71892565)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:74351108-74351408 Neighboring gene predicted gene, 57790 Neighboring gene STARR-positive B cell enhancer mm9_chr8:74352588-74352888 Neighboring gene STARR-positive B cell enhancer mm9_chr8:74358279-74358580 Neighboring gene STARR-positive B cell enhancer mm9_chr8:74358941-74359242 Neighboring gene STARR-positive B cell enhancer ABC_E5017 Neighboring gene STARR-positive B cell enhancer ABC_E10510 Neighboring gene STARR-positive B cell enhancer mm9_chr8:74367100-74367401 Neighboring gene STARR-positive B cell enhancer mm9_chr8:74368145-74368446 Neighboring gene STARR-positive B cell enhancer ABC_E6658 Neighboring gene STARR-positive B cell enhancer ABC_E8244 Neighboring gene STARR-positive B cell enhancer ABC_E6659 Neighboring gene STARR-positive B cell enhancer ABC_E6660 Neighboring gene STARR-positive B cell enhancer ABC_E6661 Neighboring gene STARR-positive B cell enhancer ABC_E9730 Neighboring gene predicted gene 5373 Neighboring gene vomeronasal 2, receptor, pseudogene 91 Neighboring gene STARR-seq mESC enhancer starr_21833 Neighboring gene STARR-positive B cell enhancer ABC_E10511 Neighboring gene cyclin B2, pseudogene Neighboring gene zinc finger protein 882 Neighboring gene zinc finger protein 617

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC28841

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 709

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145624.4 → NP_663599.3  zinc finger protein 709

    See identical proteins and their annotated locations for NP_663599.3

    Status: VALIDATED

    Source sequence(s)
    AK031294, BM941264, DV656777, DV662339
    Consensus CDS
    CCDS80897.1
    UniProtKB/TrEMBL
    Q8VC29
    Related
    ENSMUSP00000140285.2, ENSMUST00000188685.7
    Conserved Domains (5) summary
    smart00349
    Location:4 → 44
    KRAB; krueppel associated box
    COG5048
    Location:251 → 693
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:591 → 611
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:436 → 459
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72635912..72646409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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