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Acaa1b acetyl-Coenzyme A acyltransferase 1B [ Mus musculus (house mouse) ]

Gene ID: 235674, updated on 11-Apr-2024

Summary

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Official Symbol
Acaa1bprovided by MGI
Official Full Name
acetyl-Coenzyme A acyltransferase 1Bprovided by MGI
Primary source
MGI:MGI:3605455
See related
Ensembl:ENSMUSG00000010651 AllianceGenome:MGI:3605455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable C-acyltransferase activity; acetate CoA-transferase activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in monocarboxylic acid metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in alimentary system; chondrocranium; ganglia; genitourinary system; and metencephalon basal plate. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 383.0), kidney adult (RPKM 114.5) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F3; 9 71.33 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118977111..118986149, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119148043..119157093, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene villin-like Neighboring gene predicted gene, 51697 Neighboring gene phospholipase C, delta 1 Neighboring gene STARR-positive B cell enhancer ABC_E9778 Neighboring gene STARR-positive B cell enhancer ABC_E9779 Neighboring gene deleted in lung and esophageal cancer 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide pseudogene Neighboring gene solute carrier family 22 (organic cation transporter), member 14 Neighboring gene STARR-seq mESC enhancer starr_25468

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver. Fidaleo M, et al. Biochimie, 2011 May. PMID 21352884
  2. Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643. Arnauld S, et al. Biochimie, 2009 Nov-Dec. PMID 19772884
  3. Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism. Chevillard G, et al. Biochimie, 2004 Nov. PMID 15589695
  4. Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes. Chevillard G, et al. BMC Biochem, 2004 Mar 25. PMID 15043762, Free PMC Article
  5. An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Man JCK, et al. Nat Commun, 2019 Oct 30. PMID 31666509, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. acetyl-Coenzyme A acyltransferase 1B is involved in the regulation of genes encoding cholesterol biosynthesis enzymes in the liver
    Title: A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver.
  2. Molecular cloning, gene structure and tissue distribution of 3-ketoacyl-CoA thiolase B.
    Title: Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes.
  3. The region of the peroxisomal 3-ketoacyl-CoA thiolase B gene encoding the catalytic site was disrupted by homologous recombination in order to analyze the phenotype of these thiolase B-deficient mice.
    Title: Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC29978

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetate CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetyl-CoA C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA C-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA C-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-CoA oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylacetate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3-ketoacyl-CoA thiolase B, peroxisomal
Names
acetyl-CoA acyltransferase B
beta-ketothiolase B
peroxisomal 3-oxoacyl-CoA thiolase B
NP_001397554.1
NP_666342.1
XP_006512179.1
XP_011241272.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410625.1 → NP_001397554.1  3-ketoacyl-CoA thiolase B, peroxisomal isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC055818

  2. NM_146230.4 → NP_666342.1  3-ketoacyl-CoA thiolase B, peroxisomal isoform 1 precursor

    See identical proteins and their annotated locations for NP_666342.1

    Status: VALIDATED

    Source sequence(s)
    AC055818
    Consensus CDS
    CCDS23608.1
    UniProtKB/Swiss-Prot
    Q8VCH0
    UniProtKB/TrEMBL
    Q3TUU3, Q3UKM0
    Related
    ENSMUSP00000010795.5, ENSMUST00000010795.5
    Conserved Domains (2) summary
    PLN02287
    Location:1 → 420
    PLN02287; 3-ketoacyl-CoA thiolase
    cd00751
    Location:39 → 421
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    118977111..118986149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242970.1 → XP_011241272.1  3-ketoacyl-CoA thiolase B, peroxisomal isoform X1

    UniProtKB/TrEMBL
    Q3TUU3
    Conserved Domains (1) summary
    PLN02287
    Location:23 → 356
    PLN02287; 3-ketoacyl-CoA thiolase

  2. XM_006512116.5 → XP_006512179.1  3-ketoacyl-CoA thiolase B, peroxisomal isoform X3

    See identical proteins and their annotated locations for XP_006512179.1

    UniProtKB/TrEMBL
    H3BKA1
    Conserved Domains (1) summary
    PLN02287
    Location:1 → 209
    PLN02287; 3-ketoacyl-CoA thiolase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCH0.1 GenPept UniProtKB/Swiss-Prot:Q8VCH0

Gene LinkOut

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