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Apeh acylpeptide hydrolase [ Mus musculus (house mouse) ]

Gene ID: 235606, updated on 3-Apr-2024

Summary

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Official Symbol
Apehprovided by MGI
Official Full Name
acylpeptide hydrolaseprovided by MGI
Primary source
MGI:MGI:88041
See related
Ensembl:ENSMUSG00000032590 AllianceGenome:MGI:88041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity; omega peptidase activity; and serine-type endopeptidase activity. Predicted to be involved in amyloid-beta metabolic process and proteolysis. Predicted to be located in cytosol and nuclear membrane. Is expressed in dorsal root ganglion and liver lobe. Orthologous to human APEH (acylaminoacyl-peptide hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 71.8), liver E14.5 (RPKM 55.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Apeh in Genome Data Viewer
Location:
9 F1; 9 59.07 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107962613..107971736, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108085413..108094490, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3859 Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene microRNA 7088 Neighboring gene STARR-positive B cell enhancer ABC_E2914 Neighboring gene macrophage stimulating 1 (hepatocyte growth factor-like) Neighboring gene bassoon Neighboring gene RIKEN cDNA 4930447F24 gene Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development. Degen SJ, et al. Biochemistry, 1991 Oct 8. PMID 1832957
  2. Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice. Sasaki K, et al. Mol Reprod Dev, 2019 Jun. PMID 30834655, Free PMC Article
  3. Report of the sixth international workshop on human chromosome 3 mapping 1995. Naylor SL, et al. Cytogenet Cell Genet, 1996. PMID 8641130
  4. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Persons DA, et al. Nat Genet, 1999 Oct. PMID 10508511
  5. Rat gene mapping using PCR-analyzed microsatellites. Serikawa T, et al. Genetics, 1992 Jul. PMID 1628813, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38101

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables omega peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acylamino-acid-releasing enzyme
Names
AARE
APH
N-acylaminoacyl peptide hydrolase
acyl-peptide hydrolase
acylaminoacyl-peptidase
NP_001397427.1
NP_001397428.1
NP_001397429.1
NP_666338.2
XP_030100204.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410498.1 → NP_001397427.1  acylamino-acid-releasing enzyme isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC137678
    Related
    ENSMUSP00000080058.9, ENSMUST00000081309.13

  2. NM_001410499.1 → NP_001397428.1  acylamino-acid-releasing enzyme isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC137678

  3. NM_001410500.1 → NP_001397429.1  acylamino-acid-releasing enzyme isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC137678

  4. NM_146226.3 → NP_666338.2  acylamino-acid-releasing enzyme isoform 1

    See identical proteins and their annotated locations for NP_666338.2

    Status: VALIDATED

    Source sequence(s)
    AC137678
    Consensus CDS
    CCDS52923.1
    UniProtKB/Swiss-Prot
    G3X9I2, Q8K029, Q8R0M9, Q8R146
    UniProtKB/TrEMBL
    A0A0R4J107
    Related
    ENSMUSP00000141856.2, ENSMUST00000193254.6
    Conserved Domains (2) summary
    pfam00561
    Location:501 → 713
    Abhydrolase_1; alpha/beta hydrolase fold
    cl21494
    Location:510 → 707
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107962613..107971736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244344.2 → XP_030100204.1  acylamino-acid-releasing enzyme isoform X2

    Conserved Domains (1) summary
    COG1506
    Location:22 → 597
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R146.3 GenPept UniProtKB/Swiss-Prot:Q8R146

Gene LinkOut

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