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Pxylp1 2-phosphoxylose phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 235534, updated on 5-Mar-2024

Summary

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Official Symbol
Pxylp1provided by MGI
Official Full Name
2-phosphoxylose phosphatase 1provided by MGI
Primary source
MGI:MGI:2442444
See related
Ensembl:ENSMUSG00000043587 AllianceGenome:MGI:2442444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acpl2; 9430094M07Rik; C130099A20Rik
Summary
Predicted to enable phosphatase activity. Predicted to be involved in several processes, including chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; and positive regulation of heparan sulfate proteoglycan biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in central nervous system; jaw; musculoskeletal system; and olfactory epithelium. Orthologous to human PXYLP1 (2-phosphoxylose phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 9.1), CNS E14 (RPKM 7.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.3; 9 50.71 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96705396..96774732, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96823336..96892688, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C430002N11 gene Neighboring gene STARR-positive B cell enhancer ABC_E11752 Neighboring gene STARR-seq mESC enhancer starr_24980 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene peptidylprolyl isomerase A-like pseudogene Neighboring gene predicted gene, 51657

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC38214, DKFZp434B2119

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondroitin sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosaminoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-phosphoxylose phosphatase 1
Names
acid phosphatase-like 2
acid phosphatase-like protein 2
NP_001276574.1
NP_001276575.1
NP_001276576.1
NP_700469.1
XP_006511201.1
XP_006511202.1
XP_017168835.1
XP_030100200.1
XP_030100201.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289645.1 → NP_001276574.1  2-phosphoxylose phosphatase 1

    See identical proteins and their annotated locations for NP_001276574.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC120869, AK036973
    Consensus CDS
    CCDS23418.1
    UniProtKB/Swiss-Prot
    Q8BHA9, Q8BZ12
    Related
    ENSMUSP00000113210.2, ENSMUST00000120101.8
    Conserved Domains (1) summary
    cl11399
    Location:87 → 424
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  2. NM_001289646.1 → NP_001276575.1  2-phosphoxylose phosphatase 1

    See identical proteins and their annotated locations for NP_001276575.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC120869, AK144699
    Consensus CDS
    CCDS23418.1
    UniProtKB/Swiss-Prot
    Q8BHA9, Q8BZ12
    Related
    ENSMUSP00000113489.2, ENSMUST00000119141.8
    Conserved Domains (1) summary
    cl11399
    Location:87 → 424
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  3. NM_001289647.1 → NP_001276576.1  2-phosphoxylose phosphatase 1

    See identical proteins and their annotated locations for NP_001276576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC120869, AK082059
    Consensus CDS
    CCDS23418.1
    UniProtKB/Swiss-Prot
    Q8BHA9, Q8BZ12
    Related
    ENSMUSP00000077571.2, ENSMUST00000078478.8
    Conserved Domains (1) summary
    cl11399
    Location:87 → 424
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  4. NM_153420.3 → NP_700469.1  2-phosphoxylose phosphatase 1

    See identical proteins and their annotated locations for NP_700469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC120869
    Consensus CDS
    CCDS23418.1
    UniProtKB/Swiss-Prot
    Q8BHA9, Q8BZ12
    Related
    ENSMUSP00000108574.3, ENSMUST00000112951.9
    Conserved Domains (1) summary
    cl11399
    Location:87 → 424
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    96705396..96774732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511138.4 → XP_006511201.1  2-phosphoxylose phosphatase 1 isoform X1

    See identical proteins and their annotated locations for XP_006511201.1

    UniProtKB/Swiss-Prot
    Q8BHA9, Q8BZ12
    Conserved Domains (1) summary
    cl11399
    Location:87 → 424
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  2. XM_030244340.2 → XP_030100200.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8BHA9, Q8BZ12
    Conserved Domains (1) summary
    cl11399
    Location:87 → 424
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  3. XM_030244341.2 → XP_030100201.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8BHA9, Q8BZ12
    Conserved Domains (1) summary
    cl11399
    Location:87 → 424
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  4. XM_017313346.2 → XP_017168835.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8BHA9, Q8BZ12
    Conserved Domains (1) summary
    cl11399
    Location:87 → 424
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  5. XM_006511139.3 → XP_006511202.1  2-phosphoxylose phosphatase 1 isoform X2

    Conserved Domains (1) summary
    cl11399
    Location:71 → 408
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHA9.1 GenPept UniProtKB/Swiss-Prot:Q8BHA9

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