Cd109 CD109 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd109provided by MGI
Official Full Name: CD109 antigenprovided by MGI
Primary source: MGI:MGI:2445221
See related: Ensembl:ENSMUSG00000046186 AllianceGenome:MGI:2445221
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GARP; 9930012E15Rik
Summary: Predicted to enable transforming growth factor beta binding activity. Acts upstream of or within several processes, including negative regulation of keratinocyte proliferation; osteoclast fusion; and regulation of keratinocyte differentiation. Located in extracellular space. Is expressed in brain. Orthologous to human CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 3.2), testis adult (RPKM 3.0) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E1; 9 43.65 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (78522828..78623542)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (78615546..78716260)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-beta Signaling.
Title: CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling.
CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation.
Title: CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation.
Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism.
Title: Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism.
Combined Blockade of GARP:TGF-beta1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP(+) Blood Vessels in Mouse MC38 Tumors.
Title: Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP(+) Blood Vessels in Mouse MC38 Tumors.
The GARP Domain of the Rod CNG Channel's beta1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim.
Title: The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim.
Mesenchymal stroma/stem-like cells of GARP knockdown inhibits cell proliferation and invasion of mouse colon cancer cells (MC38) through exosomes.
Title: Mesenchymal stroma/stem-like cells of GARP knockdown inhibits cell proliferation and invasion of mouse colon cancer cells (MC38) through exosomes.
CD109 Restrains Activation of Cutaneous IL-17-Producing gammadelta T Cells by Commensal Microbiota.
Title: CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota.
Garp deletion in mouse Tregs is not sufficient to impair their immunosuppressive activity in vivo.
Title: Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors.
Results indicate that CD109 deficiency induces a high-turnover, osteoporosis-like phenotype, which suggests that CD109 plays a role in bone metabolism in vivo.
Title: CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo.
CD109 deficiency suppresses skin tumorigenesis by enhancing TGF-beta/Smad/Nrf2 pathway activity and decreasing the mutation frequency of the H-ras gene.
Title: Suppression of skin tumorigenesis in CD109-deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CD109 antigen

Names: GPI-anchored alpha 2 macroglobulin-related protein; Gov platelet alloantigens

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153098.3 → NP_694738.1 CD109 antigen precursor

See identical proteins and their annotated locations for NP_694738.1

Status: VALIDATED

Source sequence(s)

AI850351, DQ832284

Consensus CDS

CCDS23365.1

UniProtKB/Swiss-Prot

Q8BLT6, Q8R422

UniProtKB/TrEMBL

A6MDD3

Related

ENSMUSP00000091330.5, ENSMUST00000093812.5

Conserved Domains (7) summary

COG2373
Location:122 → 1002

YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]

cd02897
Location:909 → 1195

A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...

pfam00207
Location:695 → 782

A2M; Alpha-2-macroglobulin family

pfam01835
Location:129 → 220

A2M_N; MG2 domain

pfam07677
Location:1311 → 1395

A2M_recep; A-macroglobulin receptor

pfam07678
Location:961 → 1197

A2M_comp; A-macroglobulin complement component

pfam07703
Location:475 → 598

A2M_N_2; Alpha-2-macroglobulin family N-terminal region