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Leo1 Leo1, Paf1/RNA polymerase II complex component [ Mus musculus (house mouse) ]

Gene ID: 235497, updated on 11-Apr-2024

Summary

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Official Symbol
Leo1provided by MGI
Official Full Name
Leo1, Paf1/RNA polymerase II complex componentprovided by MGI
Primary source
MGI:MGI:2685031
See related
Ensembl:ENSMUSG00000042487 AllianceGenome:MGI:2685031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm185
Summary
Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in endodermal cell fate commitment and stem cell population maintenance. Predicted to be located in centrosome; fibrillar center; and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Predicted to be active in nucleus. Is expressed in brain; gonad; heart; and medial-nasal process mesenchyme. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.3), CNS E14 (RPKM 6.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 D; 9 42.3 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75348072..75373714)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75441015..75466432)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:75249977-75250086 Neighboring gene mitogen-activated protein kinase 6 Neighboring gene STARR-positive B cell enhancer ABC_E11414 Neighboring gene RIKEN cDNA 4933433G15 gene Neighboring gene STARR-positive B cell enhancer ABC_E3844 Neighboring gene STARR-positive B cell enhancer ABC_E6767 Neighboring gene STARR-seq mESC enhancer starr_24669 Neighboring gene predicted gene, 57538 Neighboring gene predicted gene 7972 Neighboring gene tropomodulin 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75407347-75407647

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome. Sun HY, et al. PLoS One, 2015. PMID 25933433, Free PMC Article
  2. The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain. Zhang C, et al. Neuron, 2013 Jun 19. PMID 23791194, Free PMC Article
  3. Finding the Unicorn, a New Mouse Model of Midfacial Clefting. Lantz B, et al. Genes (Basel), 2020 Jan 11. PMID 31940751, Free PMC Article
  4. Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation. Vethantham V, et al. Mol Cell Biol, 2012 Mar. PMID 22252316, Free PMC Article
  5. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Strikoudis A, et al. Nat Cell Biol, 2016 Nov. PMID 27749823, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC100232, MGC102277

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II C-terminal domain phosphoserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endodermal cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cdc73/Paf1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA polymerase-associated protein LEO1
Names
Leo1, Paf1/RNA polymerase II complex component, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039522.1 → NP_001034611.1  RNA polymerase-associated protein LEO1

    See identical proteins and their annotated locations for NP_001034611.1

    Status: VALIDATED

    Source sequence(s)
    BC082540, BC083358, CB248994
    Consensus CDS
    CCDS23343.1
    UniProtKB/Swiss-Prot
    E9QPK8, Q5XJE5, Q640R1
    Related
    ENSMUSP00000046905.5, ENSMUST00000048937.6
    Conserved Domains (2) summary
    PHA02664
    Location:61 → 209
    PHA02664; hypothetical protein; Provisional
    pfam04004
    Location:375 → 533
    Leo1; Leo1-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75348072..75373714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313344.3 → XP_017168833.1  RNA polymerase-associated protein LEO1 isoform X1

    Conserved Domains (2) summary
    COG5271
    Location:43 → 351
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam04004
    Location:375 → 537
    Leo1; Leo1-like protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006122.1: Suppressed sequence

    Description
    NM_001006122.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XJE5.2 GenPept UniProtKB/Swiss-Prot:Q5XJE5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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