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TTC33 tetratricopeptide repeat domain 33 [ Homo sapiens (human) ]

Gene ID: 23548, updated on 5-Mar-2024

Summary

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Official Symbol
TTC33provided by HGNC
Official Full Name
tetratricopeptide repeat domain 33provided by HGNC
Primary source
HGNC:HGNC:29959
See related
Ensembl:ENSG00000113638 AllianceGenome:HGNC:29959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSRF
Expression
Ubiquitous expression in brain (RPKM 7.4), thyroid (RPKM 4.0) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
5p13.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (40711576..40755961, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (40967941..41012360, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (40711678..40756063, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374737 Neighboring gene small nucleolar RNA SNORA63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:40681035-40681562 Neighboring gene prostaglandin E receptor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22503 Neighboring gene uncharacterized LOC124900968 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 1 Neighboring gene HNF1 motif-containing MPRA enhancer 12 Neighboring gene small nucleolar RNA SNORA57

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
  2. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Basei FL, et al. Proteome Sci, 2015. PMID 25798074, Free PMC Article
  3. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Yadav L, et al. Cell Syst, 2017 Apr 26. PMID 28330616
  4. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. St-Denis N, et al. Cell Rep, 2016 Nov 22. PMID 27880917
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
tetratricopeptide repeat protein 33
Names
TPR repeat protein 33
osmosis responsive factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012382.3 → NP_036514.1  tetratricopeptide repeat protein 33

    See identical proteins and their annotated locations for NP_036514.1

    Status: VALIDATED

    Source sequence(s)
    AC093264, AI174764, BC015701, BC036536, BE869916, BF509085, BM543635, BM689740, BQ922097, CR738110, DA518274, DA652008
    Consensus CDS
    CCDS3931.1
    UniProtKB/Swiss-Prot
    B2R6G0, O95105, Q6PID6
    Related
    ENSP00000338533.4, ENST00000337702.5
    Conserved Domains (2) summary
    sd00006
    Location:59 → 87
    TPR; TPR repeat [structural motif]
    cl27017
    Location:71 → 192
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    40711576..40755961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514003.4 → XP_011512305.1  tetratricopeptide repeat protein 33 isoform X1

    See identical proteins and their annotated locations for XP_011512305.1

    UniProtKB/Swiss-Prot
    B2R6G0, O95105, Q6PID6
    Conserved Domains (2) summary
    sd00006
    Location:59 → 87
    TPR; TPR repeat [structural motif]
    cl27017
    Location:71 → 192
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    40967941..41012360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352255.1 → XP_054208230.1  tetratricopeptide repeat protein 33 isoform X1

    UniProtKB/Swiss-Prot
    B2R6G0, O95105, Q6PID6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PID6.2 GenPept UniProtKB/Swiss-Prot:Q6PID6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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