Prtg protogenin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prtgprovided by MGI
Official Full Name: protogeninprovided by MGI
Primary source: MGI:MGI:2444710
See related: Ensembl:ENSMUSG00000036030 AllianceGenome:MGI:2444710
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igdcc5; A230098A12Rik
Summary: Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within negative regulation of neurogenesis. Located in plasma membrane. Is expressed in several structures, including embryo ectoderm; eye; mandible primordium; primitive streak; and somite. Orthologous to human PRTG (protogenin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 1.3), placenta adult (RPKM 0.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 40.08 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (72714556..72824589)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (72807274..72917307)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Prtg and Radil activates alpha5beta1-integrins to high-affinity conformational forms.
Title: Protogenin prevents premature apoptosis of rostral cephalic neural crest cells by activating the α5β1-integrin.
PRTG is regulated by miRNA9, plays an inhibitory action on survival of chondroblasts and articular chondrocytes during chondrogenesis and osteoarthritis pathogenesis.
Title: MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin.
This study showed that Prtg, which is a highly expressed gene in the E10.5 mouse mandible, using a cDNA subtraction method between mandibles at E10.5 and E12.0.
Title: Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.
these results suggested that expression of PRTG defines a stage between pluripotent epiblasts and committed neural progenitors, and its signaling plays a critical role in suppressing premature neuronal differentiation during early neural development.
Title: Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation.
Protogenin expression is restricted to posterior neural plate and mesoderm, with an anterior limit at the level of the rhombencephalon.
Title: Cloning of vertebrate Protogenin (Prtg) and comparative expression analysis during axis elongation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Gene trapped (3)
Endonuclease-mediated (3)

General gene information

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Markers

D9Mit340 (e-PCR), detects polymorphism
- UniSTS:116760

Prtg (e-PCR), detects polymorphism
- UniSTS:516149

NoName (e-PCR)
- UniSTS:236189

NoName (e-PCR)
- UniSTS:236191

NoName (e-PCR)
- UniSTS:236192

NoName (e-PCR)
- UniSTS:236193

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protogenin

Names: protein Shen-Dan; protogenin homolog (Gallus gallus); shen-dan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175485.4 → NP_780694.3 protogenin precursor

See identical proteins and their annotated locations for NP_780694.3

Status: VALIDATED

Source sequence(s)

AC158997, AY630257, CT027588

Consensus CDS

CCDS23331.1

UniProtKB/Swiss-Prot

A4FUS8, A4FUS9, Q2EY15, Q2VWP8, Q8BJK6, Q8BYL5

Related

ENSMUSP00000055815.8, ENSMUST00000055535.9

Conserved Domains (6) summary

cd00096
Location:146 → 201

Ig; Immunoglobulin domain

smart00408
Location:244 → 303

IGc2; Immunoglobulin C-2 Type

smart00410
Location:135 → 217

IG_like; Immunoglobulin like

cd00063
Location:815 → 905

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:321 → 406

I-set; Immunoglobulin I-set domain

cl11960
Location:34 → 124

Ig; Immunoglobulin domain