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Mindy2 MINDY lysine 48 deubiquitinase 2 [ Mus musculus (house mouse) ]

Gene ID: 235461, updated on 5-Mar-2024

Summary

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Official Symbol
Mindy2provided by MGI
Official Full Name
MINDY lysine 48 deubiquitinase 2provided by MGI
Primary source
MGI:MGI:2443086
See related
Ensembl:ENSMUSG00000042444 AllianceGenome:MGI:2443086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam63b; mKIAA1164; B230380D07Rik
Summary
Predicted to enable cysteine-type peptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in protein K48-linked deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be located in nucleoplasm. Is expressed in gut; liver lobe; nervous system; nose; and urethra. Orthologous to human MINDY2 (MINDY lysine 48 deubiquitinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 11.8), frontal lobe adult (RPKM 5.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 D; 9 39.53 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (70506296..70566429, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70599014..70657856, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22229 Neighboring gene SAFB-like, transcription modulator Neighboring gene STARR-positive B cell enhancer ABC_E11748 Neighboring gene STARR-positive B cell enhancer ABC_E2903 Neighboring gene predicted gene 10642 Neighboring gene predicted gene, 31872 Neighboring gene a disintegrin and metallopeptidase domain 10 Neighboring gene cytochrome c, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_24559 Neighboring gene STARR-seq mESC enhancer starr_24560 Neighboring gene VISTA enhancer mm190 Neighboring gene lipase, hepatic Neighboring gene ribosomal RNA processing 7 homolog A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • KIAA1164

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K11-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K6-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase MINDY-2
Names
deubiquitinating enzyme MINDY-2
family with sequence similarity 63, member B
protein FAM63B
NP_001361615.1
NP_766360.2
XP_011241034.1
XP_011241035.1
XP_011241036.1
XP_011241037.1
XP_011241038.1
XP_030100197.1
XP_036010801.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374686.1 → NP_001361615.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091263
    Consensus CDS
    CCDS90616.1
    UniProtKB/TrEMBL
    A0A1L1STF0
    Related
    ENSMUSP00000150300.2, ENSMUST00000213380.2
    Conserved Domains (2) summary
    PRK07764
    Location:14 → 202
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam04424
    Location:257 → 368
    MINDY_DUB; MINDY deubiquitinase

  2. NM_172772.2 → NP_766360.2  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform 1

    See identical proteins and their annotated locations for NP_766360.2

    Status: VALIDATED

    Source sequence(s)
    AC091263, AK035930, BC058683
    Consensus CDS
    CCDS40681.1
    UniProtKB/Swiss-Prot
    Q571N1, Q6NSV8, Q6PDI6, Q7TML6, Q8BK25, Q8BL22, Q8BL47, Q8BZC1
    Related
    ENSMUSP00000037035.6, ENSMUST00000049031.6
    Conserved Domains (2) summary
    PRK07764
    Location:14 → 202
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam04424
    Location:257 → 368
    MINDY_DUB; MINDY deubiquitinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    70506296..70566429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242736.4 → XP_011241038.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X4

    Conserved Domains (2) summary
    PRK07764
    Location:14 → 202
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam04424
    Location:257 → 368
    MINDY_DUB; MINDY deubiquitinase

  2. XM_011242735.4 → XP_011241037.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X3

    See identical proteins and their annotated locations for XP_011241037.1

    Conserved Domains (2) summary
    PRK07764
    Location:14 → 202
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam04424
    Location:257 → 368
    MINDY_DUB; MINDY deubiquitinase

  3. XM_011242733.4 → XP_011241035.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X1

    See identical proteins and their annotated locations for XP_011241035.1

    Conserved Domains (2) summary
    PRK07764
    Location:14 → 202
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam04424
    Location:257 → 368
    MINDY_DUB; MINDY deubiquitinase

  4. XM_011242732.4 → XP_011241034.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X1

    See identical proteins and their annotated locations for XP_011241034.1

    Conserved Domains (2) summary
    PRK07764
    Location:14 → 202
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam04424
    Location:257 → 368
    MINDY_DUB; MINDY deubiquitinase

  5. XM_011242734.4 → XP_011241036.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X2

    Conserved Domains (2) summary
    PRK07764
    Location:14 → 202
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam04424
    Location:257 → 368
    MINDY_DUB; MINDY deubiquitinase

  6. XM_030244337.2 → XP_030100197.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X2

    Conserved Domains (2) summary
    PRK07764
    Location:14 → 202
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam04424
    Location:257 → 368
    MINDY_DUB; MINDY deubiquitinase

  7. XM_036154908.1 → XP_036010801.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X1

    Conserved Domains (2) summary
    PRK07764
    Location:14 → 202
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam04424
    Location:257 → 368
    MINDY_DUB; MINDY deubiquitinase

RNA

  1. XR_004935418.1 RNA Sequence

  2. XR_003947881.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDI6.1 GenPept UniProtKB/Swiss-Prot:Q6PDI6

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