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Gtf2a2 general transcription factor II A, 2 [ Mus musculus (house mouse) ]

Gene ID: 235459, updated on 5-Mar-2024

Summary

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Official Symbol
Gtf2a2provided by MGI
Official Full Name
general transcription factor II A, 2provided by MGI
Primary source
MGI:MGI:1933289
See related
Ensembl:ENSMUSG00000033543 AllianceGenome:MGI:1933289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TfIIg; Tfiia2; TFIIA-gamma
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be located in cell junction and nucleoplasm. Predicted to be part of transcription factor TFIIA complex and transcription factor TFIID complex. Orthologous to human GTF2A2 (general transcription factor IIA subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 12.1), liver E14 (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 D; 9 39.18 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69919830..69930148)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70012548..70022866)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31587 Neighboring gene STARR-positive B cell enhancer ABC_E10561 Neighboring gene STARR-positive B cell enhancer ABC_E6762 Neighboring gene BCL2/adenovirus E1B interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_24528 Neighboring gene STARR-seq mESC enhancer starr_24529 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene STARR-seq mESC enhancer starr_24532 Neighboring gene predicted gene, 39369

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of general initiation factors in transcription by RNA polymerase II. Roeder RG. Trends Biochem Sci, 1996 Sep. PMID 8870495
  2. TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse. Han SY, et al. Biol Reprod, 2001 Feb. PMID 11159353
  3. The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex. Anderson DM, et al. Dev Dyn, 2009 Mar. PMID 19235719
  4. Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. Takeda S, et al. J Clin Invest, 2015 Mar 2. PMID 25664857, Free PMC Article
  5. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIA complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription initiation factor IIA subunit 2
Names
general transcription factor IIA, 2 (12kD subunit)
transcription initiation factor IIA gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039519.2 → NP_001034608.1  transcription initiation factor IIA subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_001034608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK165466, BB842876, BG088284, CR514895
    Consensus CDS
    CCDS52851.1
    UniProtKB/Swiss-Prot
    Q80ZM7
    UniProtKB/TrEMBL
    D3Z793, Q3TE88
    Related
    ENSMUSP00000113501.2, ENSMUST00000118198.8
    Conserved Domains (1) summary
    COG5123
    Location:3 → 103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

  2. NM_001282083.1 → NP_001269012.1  transcription initiation factor IIA subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_001269012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK050621, AK165466, BB842876, BG088284, CR514895
    Consensus CDS
    CCDS52851.1
    UniProtKB/Swiss-Prot
    Q80ZM7
    UniProtKB/TrEMBL
    D3Z793, Q3TE88
    Related
    ENSMUSP00000113697.2, ENSMUST00000119413.8
    Conserved Domains (1) summary
    COG5123
    Location:3 → 103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

  3. NM_001282084.1 → NP_001269013.1  transcription initiation factor IIA subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001269013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the internal coding region, which leads to a translational frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK165466, BB842876, BG088284, CR514895
    Consensus CDS
    CCDS72269.1
    UniProtKB/TrEMBL
    D3Z7C2
    Related
    ENSMUSP00000113061.2, ENSMUST00000119905.8
    Conserved Domains (1) summary
    pfam02268
    Location:3 → 49
    TFIIA_gamma_N; Transcription initiation factor IIA, gamma subunit, helical domain

RNA

  1. NR_104093.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK165466, BB842876, BC028551, CR514895
    Related
    ENSMUST00000116552.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    69919830..69930148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511116.2 → XP_006511179.1  transcription initiation factor IIA subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006511179.1

    UniProtKB/Swiss-Prot
    Q80ZM7
    UniProtKB/TrEMBL
    D3Z793, Q3TE88
    Conserved Domains (1) summary
    COG5123
    Location:3 → 103
    TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199151.1: Suppressed sequence

    Description
    NM_199151.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZM7.2 GenPept UniProtKB/Swiss-Prot:Q80ZM7

Gene LinkOut

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