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Rab8b RAB8B, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 235442, updated on 21-Apr-2024

Summary

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Official Symbol
Rab8bprovided by MGI
Official Full Name
RAB8B, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:2442982
See related
Ensembl:ENSMUSG00000036943 AllianceGenome:MGI:2442982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5930437D16; D330025I23Rik
Summary
Predicted to enable GDP binding activity; TPR domain binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including protein localization to membrane; regulation of secretion by cell; and secretion by cell. Predicted to act upstream of or within protein transport. Located in mitochondrion. Orthologous to human RAB8B (RAB8B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 15.7), liver E14.5 (RPKM 13.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 C; 9 36.17 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66750891..66826987, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66843609..66919705, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E10560 Neighboring gene STARR-seq mESC enhancer starr_24481 Neighboring gene aph1 homolog C, gamma secretase subunit Neighboring gene STARR-positive B cell enhancer ABC_E8297 Neighboring gene predicted gene, 40528 Neighboring gene STARR-positive B cell enhancer ABC_E5081 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66767210-66767393 Neighboring gene STARR-positive B cell enhancer ABC_E5082 Neighboring gene STARR-seq mESC enhancer starr_24483 Neighboring gene ribosomal protein S27-like Neighboring gene lactamase, beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab8b Regulates Transport of West Nile Virus Particles from Recycling Endosomes. Kobayashi S, et al. J Biol Chem, 2016 Mar 18. PMID 26817838, Free PMC Article
  2. Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis. Burikhanov R, et al. Cell Rep, 2017 Jan 10. PMID 28076793, Free PMC Article
  3. Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis. Sato T, et al. J Cell Sci, 2014 Jan 15. PMID 24213529, Free PMC Article
  4. TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. Pilli M, et al. Immunity, 2012 Aug 24. PMID 22921120, Free PMC Article
  5. Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form. Heidrych P, et al. Hum Mol Genet, 2008 Dec 1. PMID 18772196

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab8b is involved in trafficking of WNV particles from recycling endosomes to the plasma membrane.
    Title: Rab8b Regulates Transport of West Nile Virus Particles from Recycling Endosomes.
  2. Simultaneous loss of Rab8a and Rab8b has little effect on ciliogenesis, whereas additional loss of Rab10 greatly affects ciliogenesis.
    Title: Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis.
  3. Rab8b siRNA diminished autophagic killing of BCG, reduced the number of LC3 puncta in a high-content imaging analysis of cells stably expressing fluorescent protein fusion with LC3 and impeded basal clearance of the autophagic adaptor p62.
    Title: TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation.
  4. Otoferlin-Rab8b interaction links otoferlin to the basolateral endocytic and secretory trafficking.
    Title: Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form.
  5. These results suggest that the interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
    Title: The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TPR domain binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-substrate junction organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell projection organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of corticotropin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into peroxisome membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell tip ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related protein Rab-8B
Names
RAB44, member RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173413.3 → NP_775589.1  ras-related protein Rab-8B

    See identical proteins and their annotated locations for NP_775589.1

    Status: VALIDATED

    Source sequence(s)
    AC142504, BC059208, BY322741
    Consensus CDS
    CCDS23309.1
    UniProtKB/Swiss-Prot
    P61028, Q3U1Z3
    UniProtKB/TrEMBL
    Q0PD49
    Related
    ENSMUSP00000041857.8, ENSMUST00000041139.9
    Conserved Domains (1) summary
    cd01867
    Location:6 → 172
    Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    66750891..66826987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244336.2 → XP_030100196.1  ras-related protein Rab-8B isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:1 → 91
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61028.1 GenPept UniProtKB/Swiss-Prot:P61028

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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