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Lctl lactase-like [ Mus musculus (house mouse) ]

Gene ID: 235435, updated on 5-Mar-2024

Summary

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Official Symbol
Lctlprovided by MGI
Official Full Name
lactase-likeprovided by MGI
Primary source
MGI:MGI:2183549
See related
Ensembl:ENSMUSG00000032401 AllianceGenome:MGI:2183549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KLPH; E130104I05Rik
Summary
Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Involved in lens morphogenesis in camera-type eye. Located in brush border and endoplasmic reticulum. Orthologous to human LCTL (lactase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 18.1), liver E14 (RPKM 5.9) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Lctl in Genome Data Viewer
Location:
9 C; 9 34.5 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64024399..64045400)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64117123..64138118)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Scarletltr, erythroid developmental long intergenic non-protein coding transcript Neighboring gene STARR-positive B cell enhancer ABC_E11410 Neighboring gene predicted gene, 39360 Neighboring gene zwilch kinetochore protein Neighboring gene STARR-seq mESC enhancer starr_24420 Neighboring gene small nucleolar RNA, C/D box 16A Neighboring gene predicted gene, 23344 Neighboring gene ribosomal protein L4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The klotho-related protein KLPH (lctl) has preferred expression in lens and is essential for expression of clic5 and normal lens suture formation. Fan J, et al. Exp Eye Res, 2018 Apr. PMID 29425878, Free PMC Article
  2. Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. Ito S, et al. Biochim Biophys Acta, 2002 Jul 19. PMID 12084582
  3. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article
  4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that KLPH is required for lens-specific expression of Clic5 and that Clic5 has an important role in the machinery that controls lens fiber cell extension and organization.
    Title: The klotho-related protein KLPH (lctl) has preferred expression in lens and is essential for expression of clic5 and normal lens suture formation.
  2. Results describe a novel mouse gene klph that encodes a novel mammalian family 1 glycosidase-like protein.
    Title: Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lens morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lactase-like protein
Names
Klotho-LPH related
klotho/lactase-phlorizin hydrolase-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145835.3 → NP_665834.1  lactase-like protein precursor

    See identical proteins and their annotated locations for NP_665834.1

    Status: VALIDATED

    Source sequence(s)
    AC114674
    Consensus CDS
    CCDS23274.1
    UniProtKB/Swiss-Prot
    Q8BPR1, Q8K1F9, Q8K2M9
    Related
    ENSMUSP00000034969.8, ENSMUST00000034969.14
    Conserved Domains (1) summary
    cl23725
    Location:32 → 502
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64024399..64045400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511101.5 → XP_006511164.1  lactase-like protein isoform X1

    Conserved Domains (1) summary
    cl23725
    Location:34 → 498
    Glyco_hydro; Glycosyl hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1F9.1 GenPept UniProtKB/Swiss-Prot:Q8K1F9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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