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Coro2b coronin, actin binding protein, 2B [ Mus musculus (house mouse) ]

Gene ID: 235431, updated on 5-Mar-2024

Summary

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Official Symbol
Coro2bprovided by MGI
Official Full Name
coronin, actin binding protein, 2Bprovided by MGI
Primary source
MGI:MGI:2444283
See related
Ensembl:ENSMUSG00000041729 AllianceGenome:MGI:2444283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CLIPINC; E130012P22Rik
Summary
Predicted to enable actin filament binding activity; talin binding activity; and vinculin binding activity. Acts upstream of or within focal adhesion assembly; negative regulation of stress fiber assembly; and regulation of glomerular filtration. Located in focal adhesion. Is expressed in cerebral cortex; dorsal root ganglion; and hippocampus. Orthologous to human CORO2B (coronin 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 45.9), cortex adult (RPKM 26.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 33.71 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62326770..62444326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62419490..62537044, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40522 Neighboring gene STARR-seq mESC enhancer starr_24378 Neighboring gene VISTA enhancer mm210 Neighboring gene predicted gene, 40523 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:62336692-62336845 Neighboring gene STARR-positive B cell enhancer ABC_E1788 Neighboring gene predicted gene, 39352 Neighboring gene predicted gene, 53532

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Coronin 2B regulates dendrite outgrowth by modulating actin dynamics. Chen Y, et al. FEBS Lett, 2020 Sep. PMID 32692409
  2. Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition. Chen Y, et al. J Neurosci, 2023 Jan 11. PMID 36639906, Free PMC Article
  3. Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement. Schwarz A, et al. Sci Rep, 2019 Jun 20. PMID 31221975, Free PMC Article
  4. Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion. Xu B, et al. Cell, 2013 Jan 17. PMID 23332760, Free PMC Article
  5. Dual role of DMXL2 in olfactory information transmission and the first wave of spermatogenesis. Gobé C, et al. PLoS Genet, 2019 Feb. PMID 30735494, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition.
    Title: Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition.
  2. Coronin 2B regulates dendrite outgrowth by modulating actin dynamics.
    Title: Coronin 2B regulates dendrite outgrowth by modulating actin dynamics.
  3. CORO2B is a novel podocyte enriched protein influencing cytoskeletal plasticity and stress adaptation.
    Title: The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables talin binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables vinculin binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of cellular response to stress ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of glomerular filtration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
coronin-2B
Names
E130012P22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175484.3 → NP_780693.2  coronin-2B

    See identical proteins and their annotated locations for NP_780693.2

    Status: VALIDATED

    Source sequence(s)
    AK087414, BB647296, BC062649
    Consensus CDS
    CCDS23264.2
    UniProtKB/Swiss-Prot
    Q6P5U9, Q8BH44
    Related
    ENSMUSP00000041826.6, ENSMUST00000048043.12
    Conserved Domains (2) summary
    sd00039
    Location:45 → 85
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:15 → 460
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    62326770..62444326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511100.4 → XP_006511163.1  coronin-2B isoform X3

    See identical proteins and their annotated locations for XP_006511163.1

    UniProtKB/Swiss-Prot
    Q8BH44
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10 → 455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006511094.5 → XP_006511157.3  coronin-2B isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:65 → 105
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:35 → 480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_036154902.1 → XP_036010795.1  coronin-2B isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10 → 455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_006511099.5 → XP_006511162.1  coronin-2B isoform X3

    See identical proteins and their annotated locations for XP_006511162.1

    UniProtKB/Swiss-Prot
    Q8BH44
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10 → 455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_006511097.5 → XP_006511160.1  coronin-2B isoform X3

    See identical proteins and their annotated locations for XP_006511160.1

    UniProtKB/Swiss-Prot
    Q8BH44
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10 → 455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_006511098.5 → XP_006511161.1  coronin-2B isoform X3

    See identical proteins and their annotated locations for XP_006511161.1

    UniProtKB/Swiss-Prot
    Q8BH44
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10 → 455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_006511095.3 → XP_006511158.1  coronin-2B isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:43 → 83
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:13 → 458
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH44.2 GenPept UniProtKB/Swiss-Prot:Q8BH44

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