U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RBFOX2 RNA binding fox-1 homolog 2 [ Homo sapiens (human) ]

Gene ID: 23543, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
RBFOX2provided by HGNC
Official Full Name
RNA binding fox-1 homolog 2provided by HGNC
Primary source
HGNC:HGNC:9906
See related
Ensembl:ENSG00000100320 MIM:612149; AllianceGenome:HGNC:9906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RTA; fxh; FOX2; RBM9; Fox-2; HNRBP2; HRNBP2; dJ106I20.3
Summary
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 22.3), ovary (RPKM 20.4) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
22q12.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (35738736..36028824, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (36198484..36488569, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36134783..36424872, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S16 pseudogene 3 Neighboring gene apolipoprotein L5 Neighboring gene ribosomal protein L41 pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:36278945-36279446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:36312425-36313104 Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13660 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:36431275-36432018 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:36448074-36449273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:36481448-36482174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36512656-36513156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36513157-36513657 Neighboring gene Sharpr-MPRA regulatory region 8708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36528024-36528524 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:36530251-36531450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36537001-36537502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36537503-36538002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:36552799-36553402 Neighboring gene NANOG hESC enhancer GRCh37_chr22:36557722-36558295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18916 Neighboring gene apolipoprotein L3 Neighboring gene MT-CO1 pseudogene 20

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Jbara A, et al. Nature, 2023 May. PMID 36949200, Free PMC Article
  2. Trophoblast lineage specific expression of the alternative splicing factor RBFOX2 suggests a role in placental development. Goldman-Wohl D, et al. Placenta, 2020 Oct. PMID 32762877
  3. Alternative splicing induces cytoplasmic localization of RBFOX2 protein in calcific tendinopathy. Cho N, et al. Exp Mol Pathol, 2019 Aug. PMID 31128090
  4. Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer. Chen Y, et al. Nucleic Acids Res, 2016 May 19. PMID 27001519, Free PMC Article
  5. RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues. Venables JP, et al. Mol Cell Biol, 2013 Jan. PMID 23149937, Free PMC Article

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing.
    Title: RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing.
  2. FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.
    Title: FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.
  3. RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer.
    Title: RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer.
  4. RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.
    Title: RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.
  5. The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer.
    Title: The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer.
  6. The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.
    Title: The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.
  7. Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
    Title: Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
  8. RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis.
    Title: RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis.
  9. Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer.
    Title: Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer.
  10. SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.
    Title: SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
RNA binding protein fox-1 homolog 2
Names
RNA binding protein, fox-1 homolog 2
RNA-binding motif protein 9
fox-1 homolog B
fox-1 homologue
hexaribonucleotide-binding protein 2
repressor of tamoxifen transcriptional activity

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029628.2 RefSeqGene

    Range
    5000..295088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001031695.4 → NP_001026865.1  RNA binding protein fox-1 homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001026865.1

    Status: REVIEWED

    Source sequence(s)
    AA610054, AL049748, BC025281, DA493176
    Consensus CDS
    CCDS46700.1
    UniProtKB/Swiss-Prot
    A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
    Related
    ENSP00000391670.2, ENST00000449924.6
    Conserved Domains (3) summary
    cd12407
    Location:111 → 186
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:255 → 352
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl25887
    Location:95 → 261
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  2. NM_001082576.3 → NP_001076045.1  RNA binding protein fox-1 homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_001076045.1

    Status: REVIEWED

    Source sequence(s)
    AA610054, AL049748, CR456559, DA493176
    Consensus CDS
    CCDS46701.1
    UniProtKB/Swiss-Prot
    A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
    Related
    ENSP00000405651.2, ENST00000416721.6
    Conserved Domains (3) summary
    TIGR01645
    Location:95 → 247
    half-pint; poly-U binding splicing factor, half-pint family
    pfam12414
    Location:251 → 348
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:111 → 186
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  3. NM_001082577.3 → NP_001076046.1  RNA binding protein fox-1 homolog 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AA610054, AL049748, AY960684, DA493176
    Consensus CDS
    CCDS46699.1
    UniProtKB/TrEMBL
    F8WSN4
    Related
    ENSP00000407855.2, ENST00000414461.6
    Conserved Domains (3) summary
    COG0724
    Location:70 → 195
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:111 → 186
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:255 → 303
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  4. NM_001082578.4 → NP_001076047.2  RNA binding protein fox-1 homolog 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    Consensus CDS
    CCDS43013.1
    UniProtKB/TrEMBL
    A0A0G2JRA5
    Related
    ENSP00000413035.2, ENST00000438146.7
    Conserved Domains (3) summary
    TIGR01645
    Location:166 → 332
    half-pint; poly-U binding splicing factor, half-pint family
    pfam12414
    Location:326 → 423
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:182 → 257
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  5. NM_001082579.3 → NP_001076048.2  RNA binding protein fox-1 homolog 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    UniProtKB/Swiss-Prot
    A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
    Conserved Domains (3) summary
    TIGR01645
    Location:165 → 331
    half-pint; poly-U binding splicing factor, half-pint family
    pfam12414
    Location:325 → 422
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:181 → 256
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  6. NM_001349982.2 → NP_001336911.1  RNA binding protein fox-1 homolog 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AA610054, AL035800, AL049748, CR456559, DA776762, HY155887, HY351263
    UniProtKB/TrEMBL
    B0QYY4
    Conserved Domains (3) summary
    cd12407
    Location:133 → 208
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:273 → 330
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl25887
    Location:117 → 269
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  7. NM_001349983.2 → NP_001336912.1  RNA binding protein fox-1 homolog 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AA610054, AL049748, CN399960, CR456559, HY351263
    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    cd12407
    Location:111 → 186
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:251 → 308
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl25887
    Location:95 → 247
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  8. NM_001349989.2 → NP_001336918.1  RNA binding protein fox-1 homolog 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z82217
    UniProtKB/Swiss-Prot
    A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
    Conserved Domains (3) summary
    cd12407
    Location:133 → 208
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:277 → 374
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl25887
    Location:117 → 283
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  9. NM_001349990.2 → NP_001336919.1  RNA binding protein fox-1 homolog 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z82217
    UniProtKB/Swiss-Prot
    A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
    Conserved Domains (3) summary
    TIGR01645
    Location:117 → 269
    half-pint; poly-U binding splicing factor, half-pint family
    pfam12414
    Location:273 → 370
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:133 → 208
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  10. NM_001349991.2 → NP_001336920.1  RNA binding protein fox-1 homolog 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z82217
    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    cd12407
    Location:133 → 208
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:277 → 334
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl25887
    Location:117 → 283
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  11. NM_001349992.2 → NP_001336921.1  RNA binding protein fox-1 homolog 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z82217
    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    cd12407
    Location:133 → 208
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:277 → 325
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl25887
    Location:117 → 283
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  12. NM_001349994.2 → NP_001336923.1  RNA binding protein fox-1 homolog 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z82217
    UniProtKB/TrEMBL
    B0QYY4
    Conserved Domains (2) summary
    cd12407
    Location:133 → 208
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:273 → 321
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  13. NM_001349995.2 → NP_001336924.1  RNA binding protein fox-1 homolog 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z82217
    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    COG0724
    Location:92 → 167
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam12414
    Location:246 → 294
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl17169
    Location:133 → 172
    RRM_SF; RNA recognition motif (RRM) superfamily

  14. NM_001349996.2 → NP_001336925.1  RNA binding protein fox-1 homolog 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z82217
    UniProtKB/TrEMBL
    A0A0G2JRA5
    Conserved Domains (2) summary
    cd12407
    Location:134 → 208
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:273 → 370
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  15. NM_001349997.2 → NP_001336926.1  RNA binding protein fox-1 homolog 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AK291460, AL049748
    UniProtKB/TrEMBL
    A0A0G2JRA5
    Conserved Domains (3) summary
    cd12407
    Location:112 → 187
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:256 → 353
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl25887
    Location:96 → 262
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  16. NM_001349998.2 → NP_001336927.1  RNA binding protein fox-1 homolog 2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AB649123, AL049748, AL079295
    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    cd12407
    Location:111 → 186
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:255 → 312
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl25887
    Location:95 → 261
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  17. NM_001349999.2 → NP_001336928.2  RNA binding protein fox-1 homolog 2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    Consensus CDS
    CCDS93157.1
    UniProtKB/TrEMBL
    A0A0G2JRA5, A0A8Q3WKT3
    Related
    ENSP00000512219.1, ENST00000695854.1
    Conserved Domains (2) summary
    pfam12414
    Location:322 → 419
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:182 → 257
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  18. NM_001394108.1 → NP_001381037.1  RNA binding protein fox-1 homolog 2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    UniProtKB/Swiss-Prot
    A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
    Conserved Domains (2) summary
    smart00360
    Location:182 → 251
    RRM; RNA recognition motif
    TIGR01648
    Location:173 → 379
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  19. NM_001394109.1 → NP_001381038.1  RNA binding protein fox-1 homolog 2 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    UniProtKB/TrEMBL
    A0A0G2JRA5
    Conserved Domains (1) summary
    smart00360
    Location:183 → 216
    RRM; RNA recognition motif

  20. NM_001394110.1 → NP_001381039.1  RNA binding protein fox-1 homolog 2 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    UniProtKB/Swiss-Prot
    A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
    Conserved Domains (2) summary
    smart00360
    Location:182 → 216
    RRM; RNA recognition motif
    COG0724
    Location:140 → 215
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  21. NM_001394111.1 → NP_001381040.1  RNA binding protein fox-1 homolog 2 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (2) summary
    smart00360
    Location:182 → 216
    RRM; RNA recognition motif
    COG0724
    Location:140 → 215
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  22. NM_001394112.1 → NP_001381041.1  RNA binding protein fox-1 homolog 2 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    UniProtKB/TrEMBL
    A0A0G2JRA5
    Conserved Domains (2) summary
    smart00360
    Location:183 → 252
    RRM; RNA recognition motif
    TIGR01648
    Location:174 → 380
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  23. NM_001394113.1 → NP_001381042.1  RNA binding protein fox-1 homolog 2 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    UniProtKB/Swiss-Prot
    A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
    Conserved Domains (2) summary
    pfam12414
    Location:321 → 418
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:181 → 256
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  24. NM_001394114.1 → NP_001381043.1  RNA binding protein fox-1 homolog 2 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    UniProtKB/TrEMBL
    A0A8Q3SI75
    Conserved Domains (2) summary
    pfam12414
    Location:322 → 370
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:182 → 257
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  25. NM_001394115.1 → NP_001381044.1  RNA binding protein fox-1 homolog 2 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL049748, AL079295, Z95114
    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (2) summary
    pfam12414
    Location:321 → 369
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:181 → 256
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  26. NM_014309.4 → NP_055124.1  RNA binding protein fox-1 homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_055124.1

    Status: REVIEWED

    Source sequence(s)
    AA610054, AL009266, AL049748, DA493176
    Consensus CDS
    CCDS13921.1
    UniProtKB/TrEMBL
    A0A8Q3SI75
    Related
    ENSP00000384944.2, ENST00000405409.6
    Conserved Domains (3) summary
    COG0724
    Location:95 → 196
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:112 → 187
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:252 → 300
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    35738736..36028824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261429.3 → XP_005261486.1  RNA binding protein fox-1 homolog 2 isoform X4

    UniProtKB/TrEMBL
    B0QYY4
    Conserved Domains (3) summary
    COG0724
    Location:140 → 265
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:181 → 256
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:321 → 378
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  2. XM_006724186.3 → XP_006724249.1  RNA binding protein fox-1 homolog 2 isoform X2

    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    COG0724
    Location:140 → 265
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:181 → 256
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:325 → 382
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  3. XM_005261430.3 → XP_005261487.1  RNA binding protein fox-1 homolog 2 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JRA5
    Conserved Domains (3) summary
    COG0724
    Location:165 → 266
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:182 → 257
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:322 → 420
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  4. XM_005261428.3 → XP_005261485.1  RNA binding protein fox-1 homolog 2 isoform X3

    UniProtKB/TrEMBL
    B0QYY4
    Conserved Domains (3) summary
    COG0724
    Location:165 → 266
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:182 → 257
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:322 → 379
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  5. XM_006724188.3 → XP_006724251.1  RNA binding protein fox-1 homolog 2 isoform X8

    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    COG0724
    Location:165 → 266
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:182 → 257
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:326 → 374
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  6. XM_006724187.3 → XP_006724250.1  RNA binding protein fox-1 homolog 2 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JRA5
    Conserved Domains (3) summary
    COG0724
    Location:165 → 266
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:182 → 257
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:326 → 424
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  7. XM_006724185.3 → XP_006724248.1  RNA binding protein fox-1 homolog 2 isoform X1

    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    COG0724
    Location:165 → 266
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:182 → 257
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:326 → 383
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  8. XM_017028686.1 → XP_016884175.1  RNA binding protein fox-1 homolog 2 isoform X7

    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    COG0724
    Location:107 → 208
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:124 → 199
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:268 → 325
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  9. XM_047441254.1 → XP_047297210.1  RNA binding protein fox-1 homolog 2 isoform X22

  10. XM_047441251.1 → XP_047297207.1  RNA binding protein fox-1 homolog 2 isoform X16

  11. XM_047441250.1 → XP_047297206.1  RNA binding protein fox-1 homolog 2 isoform X12

  12. XM_006724189.4 → XP_006724252.1  RNA binding protein fox-1 homolog 2 isoform X11

    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    COG0724
    Location:117 → 218
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:134 → 209
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:278 → 335
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  13. XM_017028687.3 → XP_016884176.1  RNA binding protein fox-1 homolog 2 isoform X9

    UniProtKB/TrEMBL
    F8WSN4

  14. XM_024452188.2 → XP_024307956.1  RNA binding protein fox-1 homolog 2 isoform X10

    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    cd12407
    Location:155 → 230
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:299 → 356
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl25887
    Location:139 → 305
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  15. XM_047441260.1 → XP_047297216.1  RNA binding protein fox-1 homolog 2 isoform X31

  16. XM_047441258.1 → XP_047297214.1  RNA binding protein fox-1 homolog 2 isoform X28

  17. XM_024452191.2 → XP_024307959.1  RNA binding protein fox-1 homolog 2 isoform X27

    UniProtKB/TrEMBL
    A8MVJ8, B0QYV1
    Conserved Domains (3) summary
    cd12407
    Location:107 → 182
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:247 → 344
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl25887
    Location:91 → 243
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  18. XM_047441253.1 → XP_047297209.1  RNA binding protein fox-1 homolog 2 isoform X21

    Related
    ENSP00000352328.4, ENST00000359369.8

  19. XM_047441252.1 → XP_047297208.1  RNA binding protein fox-1 homolog 2 isoform X20

  20. XM_047441259.1 → XP_047297215.1  RNA binding protein fox-1 homolog 2 isoform X30

  21. XM_006724192.3 → XP_006724255.1  RNA binding protein fox-1 homolog 2 isoform X18

    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    COG0724
    Location:91 → 192
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:108 → 183
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:252 → 309
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  22. XM_047441257.1 → XP_047297213.1  RNA binding protein fox-1 homolog 2 isoform X26

  23. XM_017028691.2 → XP_016884180.1  RNA binding protein fox-1 homolog 2 isoform X14

    UniProtKB/TrEMBL
    F8WSN4

  24. XM_017028690.2 → XP_016884179.1  RNA binding protein fox-1 homolog 2 isoform X13

    UniProtKB/TrEMBL
    F8WSN4

  25. XM_017028698.2 → XP_016884187.1  RNA binding protein fox-1 homolog 2 isoform X29

    UniProtKB/TrEMBL
    F8WSN4

  26. XM_047441256.1 → XP_047297212.1  RNA binding protein fox-1 homolog 2 isoform X25

  27. XM_047441255.1 → XP_047297211.1  RNA binding protein fox-1 homolog 2 isoform X23

  28. XM_017028696.2 → XP_016884185.1  RNA binding protein fox-1 homolog 2 isoform X24

    UniProtKB/TrEMBL
    A8MVJ8, B0QYV1
    Related
    ENSP00000512183.1, ENST00000695803.1
    Conserved Domains (3) summary
    TIGR01645
    Location:96 → 248
    half-pint; poly-U binding splicing factor, half-pint family
    cd12407
    Location:112 → 187
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:252 → 349
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  29. XM_017028693.2 → XP_016884182.1  RNA binding protein fox-1 homolog 2 isoform X17

    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    COG0724
    Location:95 → 196
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:112 → 187
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:252 → 309
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  30. XM_006724191.2 → XP_006724254.1  RNA binding protein fox-1 homolog 2 isoform X15

    UniProtKB/TrEMBL
    F8WSN4
    Conserved Domains (3) summary
    COG0724
    Location:95 → 196
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:112 → 187
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:256 → 313
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  31. XM_006724193.4 → XP_006724256.1  RNA binding protein fox-1 homolog 2 isoform X19

    UniProtKB/TrEMBL
    A0A0G2JRA5
    Conserved Domains (3) summary
    COG0724
    Location:165 → 266
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:182 → 257
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:326 → 383
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187630.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    59734..259897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    36198484..36488569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325369.1 → XP_054181344.1  RNA binding protein fox-1 homolog 2 isoform X4

  2. XM_054325367.1 → XP_054181342.1  RNA binding protein fox-1 homolog 2 isoform X2

  3. XM_054325371.1 → XP_054181346.1  RNA binding protein fox-1 homolog 2 isoform X6

  4. XM_054325368.1 → XP_054181343.1  RNA binding protein fox-1 homolog 2 isoform X3

  5. XM_054325373.1 → XP_054181348.1  RNA binding protein fox-1 homolog 2 isoform X8

  6. XM_054325370.1 → XP_054181345.1  RNA binding protein fox-1 homolog 2 isoform X5

  7. XM_054325366.1 → XP_054181341.1  RNA binding protein fox-1 homolog 2 isoform X1

  8. XM_054325372.1 → XP_054181347.1  RNA binding protein fox-1 homolog 2 isoform X7

  9. XM_054325387.1 → XP_054181362.1  RNA binding protein fox-1 homolog 2 isoform X22

  10. XM_054325381.1 → XP_054181356.1  RNA binding protein fox-1 homolog 2 isoform X16

  11. XM_054325377.1 → XP_054181352.1  RNA binding protein fox-1 homolog 2 isoform X12

  12. XM_054325376.1 → XP_054181351.1  RNA binding protein fox-1 homolog 2 isoform X11

  13. XM_054325374.1 → XP_054181349.1  RNA binding protein fox-1 homolog 2 isoform X9

  14. XM_054325375.1 → XP_054181350.1  RNA binding protein fox-1 homolog 2 isoform X10

  15. XM_054325395.1 → XP_054181370.1  RNA binding protein fox-1 homolog 2 isoform X30

  16. XM_054325383.1 → XP_054181358.1  RNA binding protein fox-1 homolog 2 isoform X18

  17. XM_054325393.1 → XP_054181368.1  RNA binding protein fox-1 homolog 2 isoform X28

  18. XM_054325396.1 → XP_054181371.1  RNA binding protein fox-1 homolog 2 isoform X31

  19. XM_054325392.1 → XP_054181367.1  RNA binding protein fox-1 homolog 2 isoform X27

  20. XM_054325386.1 → XP_054181361.1  RNA binding protein fox-1 homolog 2 isoform X21

  21. XM_054325385.1 → XP_054181360.1  RNA binding protein fox-1 homolog 2 isoform X20

  22. XM_054325391.1 → XP_054181366.1  RNA binding protein fox-1 homolog 2 isoform X26

  23. XM_054325379.1 → XP_054181354.1  RNA binding protein fox-1 homolog 2 isoform X14

  24. XM_054325378.1 → XP_054181353.1  RNA binding protein fox-1 homolog 2 isoform X13

  25. XM_054325394.1 → XP_054181369.1  RNA binding protein fox-1 homolog 2 isoform X29

  26. XM_054325390.1 → XP_054181365.1  RNA binding protein fox-1 homolog 2 isoform X25

  27. XM_054325388.1 → XP_054181363.1  RNA binding protein fox-1 homolog 2 isoform X23

  28. XM_054325389.1 → XP_054181364.1  RNA binding protein fox-1 homolog 2 isoform X24

  29. XM_054325382.1 → XP_054181357.1  RNA binding protein fox-1 homolog 2 isoform X17

  30. XM_054325380.1 → XP_054181355.1  RNA binding protein fox-1 homolog 2 isoform X15

  31. XM_054325384.1 → XP_054181359.1  RNA binding protein fox-1 homolog 2 isoform X19

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43251.3 GenPept UniProtKB/Swiss-Prot:O43251

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous