Gldn gliomedin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gldnprovided by MGI
Official Full Name: gliomedinprovided by MGI
Primary source: MGI:MGI:2388361
See related: Ensembl:ENSMUSG00000046167 AllianceGenome:MGI:2388361
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clom; Colm; Crgl2; Crlg2; CRG-L2
Summary: Enables protein binding activity involved in heterotypic cell-cell adhesion. Acts upstream of or within clustering of voltage-gated sodium channels; heterotypic cell-cell adhesion; and microvillus organization. Located in extracellular space and plasma membrane. Is expressed in several structures, including genitourinary system; heart; lung; skeletal muscle; and spleen. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human GLDN (gliomedin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 29.52 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (54193770..54249061)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (54286486..54341777)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Precise Spatiotemporal Control of Nodal Na(+) Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases.
Title: Precise Spatiotemporal Control of Nodal Na(+) Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases.
OLF domains from H. sapiens olfactomedin-1 and M. musculus gliomedin were biophysically, biochemically, and structurally characterized.
Title: Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies.
Perlecan binds the clustering molecule gliomedin and enhances clustering of node of Ranvier components.
Title: Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin.
Here, we show that initial clustering of Na(+) channels at heminodes requires glial NrCAM and gliomedin, as well as their axonal receptor neurofascin 186 (NF186).
Title: A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Clom (e-PCR), detects polymorphism
- UniSTS:265063

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding involved in heterotypic cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within clustering of voltage-gated sodium channels	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heterotypic cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within microvillus organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gliomedin

Names: cancer related gene - liver 2; cancer-related gene liver 2 protein; collomin; olfactomedin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177350.5 → NP_796324.1 gliomedin

See identical proteins and their annotated locations for NP_796324.1

Status: PROVISIONAL

Source sequence(s)

AC162180

Consensus CDS

CCDS23189.1

UniProtKB/Swiss-Prot

Q80ZC5, Q8BMF8

UniProtKB/TrEMBL

Q08AT9

Related

ENSMUSP00000056080.6, ENSMUST00000056740.6

Conserved Domains (3) summary

pfam01391
Location:160 → 217

Collagen; Collagen triple helix repeat (20 copies)

pfam02191
Location:301 → 539

OLF; Olfactomedin-like domain

pfam11828
Location:22 → 90

DUF3348; Protein of unknown function (DUF3348)