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Sik2 salt inducible kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 235344, updated on 21-Apr-2024

Summary

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Official Symbol
Sik2provided by MGI
Official Full Name
salt inducible kinase 2provided by MGI
Primary source
MGI:MGI:2445031
See related
Ensembl:ENSMUSG00000037112 AllianceGenome:MGI:2445031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Snf1lk2; G630080D20Rik
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and regulation of insulin receptor signaling pathway. Acts upstream of or within insulin receptor signaling pathway and protein phosphorylation. Located in cytoplasm and nucleus. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 39.2), mammary gland adult (RPKM 30.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 27.75 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50800944..50920432, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50889644..51009132, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene predicted gene, 57547 Neighboring gene STARR-seq mESC enhancer starr_24122 Neighboring gene STARR-positive B cell enhancer mm9_chr9:50664895-50665195 Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene predicted gene, 25558 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene BTG anti-proliferation factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury. van Gijsel-Bonnello M, et al. J Biol Chem, 2022 Dec. PMID 36309093, Free PMC Article
  2. Bosutinib Attenuates Inflammation via Inhibiting Salt-Inducible Kinases in Experimental Model of Intracerebral Hemorrhage on Mice. Ma L, et al. Stroke, 2017 Nov. PMID 29018127, Free PMC Article
  3. SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes. Henriksson E, et al. J Cell Sci, 2015 Feb 1. PMID 25472719, Free PMC Article
  4. The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases. Ozanne J, et al. Biochem J, 2015 Jan 15. PMID 25351958, Free PMC Article
  5. Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake. Popov S, et al. PLoS One, 2014. PMID 24752134, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury.
    Title: Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury.
  2. SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
    Title: SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
  3. Salt inducible kinases 2 and 3 are required for thymic T cell development.
    Title: Salt inducible kinases 2 and 3 are required for thymic T cell development.
  4. Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
    Title: Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
  5. Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.
    Title: Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells.
  6. Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake.
    Title: Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake.
  7. Salt-inducible Kinases Are Critical Determinants of Female Fertility.
    Title: Salt-inducible Kinases Are Critical Determinants of Female Fertility.
  8. Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
    Title: Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
  9. Silencing Sik2 further diminished SIRT3 activity and enhanced acetylation of PDHA1 K83 level. Reconstruction of SIRT3 restored PDH activity and thermogenic markers expression in differentiated brown adipocytes from SIRT3 knockout (KO) mice.
    Title: Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions.
  10. hippocampal SIK2-CRTC1 pathway is involved in the pathogenesis of depression.
    Title: Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription from RNA polymerase II promoter by glucose IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription from RNA polymerase II promoter by glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase SIK2
Names
SIK-2
SNF1-like kinase 2
salt induceable kinase 2
salt-inducible protein kinase 2
serine/threonine-protein kinase SNF1-like kinase 2
NP_001391943.1
NP_001391944.1
NP_848825.2
XP_006510330.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405014.1 → NP_001391943.1  serine/threonine-protein kinase SIK2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC103406
    UniProtKB/TrEMBL
    H3BKG1
    Related
    ENSMUSP00000135376.2, ENSMUST00000176663.8

  2. NM_001405015.1 → NP_001391944.1  serine/threonine-protein kinase SIK2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC103406

  3. NM_178710.4 → NP_848825.2  serine/threonine-protein kinase SIK2 isoform 1

    See identical proteins and their annotated locations for NP_848825.2

    Status: VALIDATED

    Source sequence(s)
    AC103406
    Consensus CDS
    CCDS40627.1
    UniProtKB/Swiss-Prot
    Q8CFH6
    UniProtKB/TrEMBL
    F8VPT7
    Related
    ENSMUSP00000038761.11, ENSMUST00000041375.11
    Conserved Domains (3) summary
    smart00220
    Location:20 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14409
    Location:297 → 341
    UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
    cd14071
    Location:19 → 271
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50800944..50920432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510267.3 → XP_006510330.1  serine/threonine-protein kinase SIK2 isoform X2

    UniProtKB/Swiss-Prot
    Q8CFH6
    Conserved Domains (2) summary
    cd14409
    Location:297 → 341
    UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
    cd14071
    Location:19 → 271
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RNA

  1. XR_379116.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFH6.1 GenPept UniProtKB/Swiss-Prot:Q8CFH6

Gene LinkOut

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