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Rnf214 ring finger protein 214 [ Mus musculus (house mouse) ]

Gene ID: 235315, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf214provided by MGI
Official Full Name
ring finger protein 214provided by MGI
Primary source
MGI:MGI:2444451
See related
Ensembl:ENSMUSG00000042790 AllianceGenome:MGI:2444451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D130054N24Rik
Summary
Predicted to enable ubiquitin-protein transferase activity. Orthologous to human RNF214 (ring finger protein 214). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 13.2), cerebellum adult (RPKM 12.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.2; 9 25.26 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45768067..45818209, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45856769..45906911, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 164 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45636585-45636886 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45637216-45637517 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45655339-45655522 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene beta-site APP cleaving enzyme 1 Neighboring gene predicted gene, 24646 Neighboring gene STARR-seq mESC enhancer starr_24009 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene transgelin Neighboring gene microRNA 7087 Neighboring gene SID1 transmembrane family, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Faghihi MA, et al. Nat Med, 2008 Jul. PMID 18587408, Free PMC Article
  2. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
  3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
RING finger protein 214

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310839.2 → NP_001297768.1  RING finger protein 214 isoform 2

    See identical proteins and their annotated locations for NP_001297768.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK028768, AK032376, AK051527, AK136229, BY785775, CJ286540
    Consensus CDS
    CCDS80987.1
    UniProtKB/Swiss-Prot
    Q8BFU3
    Related
    ENSMUSP00000124296.2, ENSMUST00000161187.8
    Conserved Domains (1) summary
    cd16477
    Location:466 → 510
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  2. NM_001310840.2 → NP_001297769.1  RING finger protein 214 isoform 3

    See identical proteins and their annotated locations for NP_001297769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site in the 5' coding region, and contains an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AK030208, AK032376, AK136229, BY785775, CJ286540
    Consensus CDS
    CCDS80988.1
    UniProtKB/Swiss-Prot
    Q8BFU3
    Related
    ENSMUSP00000123995.2, ENSMUST00000161203.8
    Conserved Domains (1) summary
    cd16477
    Location:501 → 545
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  3. NM_001361112.1 → NP_001348041.1  RING finger protein 214 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK030208, AK136229, BY785775, CJ286540
    Consensus CDS
    CCDS23136.1
    UniProtKB/Swiss-Prot
    Q3UWM9, Q6P3A7, Q80VI8, Q8BFU3, Q8BNZ6, Q8CC56, Q8CCP2, Q8CE92, Q8R5B9
    Related
    ENSMUSP00000123754.2, ENSMUST00000160699.9
    Conserved Domains (1) summary
    cd16477
    Location:621 → 665
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  4. NM_001361113.1 → NP_001348042.1  RING finger protein 214 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK028768, AK136229, BY785775, CJ286540
    Conserved Domains (1) summary
    cd16477
    Location:566 → 610
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  5. NM_001361114.1 → NP_001348043.1  RING finger protein 214 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126804
    Consensus CDS
    CCDS80987.1
    Conserved Domains (1) summary
    cd16477
    Location:466 → 510
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  6. NM_178709.5 → NP_848824.1  RING finger protein 214 isoform 1

    See identical proteins and their annotated locations for NP_848824.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC126804
    Consensus CDS
    CCDS23136.1
    UniProtKB/Swiss-Prot
    Q3UWM9, Q6P3A7, Q80VI8, Q8BFU3, Q8BNZ6, Q8CC56, Q8CCP2, Q8CE92, Q8R5B9
    Related
    ENSMUSP00000060941.6, ENSMUST00000058720.13
    Conserved Domains (1) summary
    cd16477
    Location:621 → 665
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45768067..45818209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242496.3 → XP_011240798.1  RING finger protein 214 isoform X1

    See identical proteins and their annotated locations for XP_011240798.1

    Conserved Domains (1) summary
    cd16477
    Location:656 → 700
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  2. XM_036154891.1 → XP_036010784.1  RING finger protein 214 isoform X7

    Conserved Domains (1) summary
    cd16477
    Location:393 → 437
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  3. XM_036154890.1 → XP_036010783.1  RING finger protein 214 isoform X2

    UniProtKB/Swiss-Prot
    Q3UWM9, Q6P3A7, Q80VI8, Q8BFU3, Q8BNZ6, Q8CC56, Q8CCP2, Q8CE92, Q8R5B9
    Conserved Domains (1) summary
    cd16477
    Location:621 → 665
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  4. XM_036154888.1 → XP_036010781.1  RING finger protein 214 isoform X1

    Conserved Domains (1) summary
    cd16477
    Location:656 → 700
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  5. XM_030244319.1 → XP_030100179.1  RING finger protein 214 isoform X1

    Conserved Domains (1) summary
    cd16477
    Location:656 → 700
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  6. XM_030244316.1 → XP_030100176.1  RING finger protein 214 isoform X3

    Conserved Domains (1) summary
    cd16477
    Location:601 → 645
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  7. XM_030244320.1 → XP_030100180.1  RING finger protein 214 isoform X6

    Conserved Domains (1) summary
    cd16477
    Location:428 → 472
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  8. XM_030244322.1 → XP_030100182.1  RING finger protein 214 isoform X7

    Conserved Domains (1) summary
    cd16477
    Location:393 → 437
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  9. XM_030244318.2 → XP_030100178.1  RING finger protein 214 isoform X4

    Conserved Domains (1) summary
    cd16477
    Location:566 → 610
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  10. XM_030244321.2 → XP_030100181.1  RING finger protein 214 isoform X6

    Conserved Domains (1) summary
    cd16477
    Location:428 → 472
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  11. XM_030244315.2 → XP_030100175.1  RING finger protein 214 isoform X3

    Conserved Domains (1) summary
    cd16477
    Location:601 → 645
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  12. XM_030244317.2 → XP_030100177.1  RING finger protein 214 isoform X4

    Conserved Domains (1) summary
    cd16477
    Location:566 → 610
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  13. XM_036154889.1 → XP_036010782.1  RING finger protein 214 isoform X2

    UniProtKB/Swiss-Prot
    Q3UWM9, Q6P3A7, Q80VI8, Q8BFU3, Q8BNZ6, Q8CC56, Q8CCP2, Q8CE92, Q8R5B9
    Conserved Domains (1) summary
    cd16477
    Location:621 → 665
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  14. XM_030244314.2 → XP_030100174.1  RING finger protein 214 isoform X1

    Conserved Domains (1) summary
    cd16477
    Location:656 → 700
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins

  15. XM_011242503.3 → XP_011240805.1  RING finger protein 214 isoform X5

    See identical proteins and their annotated locations for XP_011240805.1

    UniProtKB/Swiss-Prot
    Q8BFU3
    Conserved Domains (1) summary
    cd16477
    Location:501 → 545
    RING-H2_RNF214; RING finger, H2 subclass, found in RING finger protein 214 (RNF214) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFU3.1 GenPept UniProtKB/Swiss-Prot:Q8BFU3

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