U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zbtb44 zinc finger and BTB domain containing 44 [ Mus musculus (house mouse) ]

Gene ID: 235132, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Zbtb44provided by MGI
Official Full Name
zinc finger and BTB domain containing 44provided by MGI
Primary source
MGI:MGI:1925123
See related
Ensembl:ENSMUSG00000047412 AllianceGenome:MGI:1925123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Btbd15; E230011F09; 6030404E16Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZBTB44 (zinc finger and BTB domain containing 44). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 5.6), adrenal adult (RPKM 3.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 A4; 9 16.56 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (30941016..30987181)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (31029720..31075885)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 8 Neighboring gene predicted gene, 29724 Neighboring gene STARR-seq mESC enhancer starr_23676 Neighboring gene STARR-seq mESC enhancer starr_23679 Neighboring gene STARR-positive B cell enhancer ABC_E6719 Neighboring gene STARR-seq mESC enhancer starr_23682 Neighboring gene STARR-seq mESC enhancer starr_23684 Neighboring gene predicted gene, 17508 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene suppression of tumorigenicity 14 (colon carcinoma) Neighboring gene STARR-seq mESC enhancer starr_23691 Neighboring gene amyloid beta precursor-like protein 2 Neighboring gene protein CEBPZOS pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  3. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger and BTB domain-containing protein 44
Names
BTB (POZ) domain containing 15
BTB/POZ domain-containing protein 15

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115130.1 → NP_001108602.1  zinc finger and BTB domain-containing protein 44 isoform a

    See identical proteins and their annotated locations for NP_001108602.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK036895, BC027138, BC090965, CT025653
    Consensus CDS
    CCDS52747.1
    UniProtKB/Swiss-Prot
    Q8CB31, Q8R0A2
    Related
    ENSMUSP00000110877.3, ENSMUST00000115222.10
    Conserved Domains (6) summary
    smart00225
    Location:32 → 128
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:383 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401 → 421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:399 → 421
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:21 → 125
    BTB; BTB/POZ domain
    pfam13465
    Location:413 → 438
    zf-H2C2_2; Zinc-finger double domain

  2. NM_172765.3 → NP_766353.2  zinc finger and BTB domain-containing protein 44 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) uses an alternate in-frame splice site in the 3' coding region, compared to variant a. It encodes a shorter isoform (b), compared to isoform a.
    Source sequence(s)
    AK036895, BC027138, BC090965, CT025653
    Consensus CDS
    CCDS40568.1
    UniProtKB/Swiss-Prot
    Q8R0A2
    Related
    ENSMUSP00000149386.2, ENSMUST00000216649.2
    Conserved Domains (6) summary
    smart00225
    Location:32 → 128
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:351 → 431
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:381 → 403
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:21 → 125
    BTB; BTB/POZ domain
    pfam13465
    Location:395 → 420
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    30941016..30987181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510215.5 → XP_006510278.1  zinc finger and BTB domain-containing protein 44 isoform X1

    UniProtKB/TrEMBL
    A0A1L1SQN1, A0A1L1SSL7
    Related
    ENSMUSP00000149969.2, ENSMUST00000217092.2
    Conserved Domains (5) summary
    sd00017
    Location:401 → 421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:489 → 511
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:399 → 421
    zf-C2H2; Zinc finger, C2H2 type
    cd18228
    Location:15 → 130
    BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)
    pfam13465
    Location:413 → 438
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006510216.5 → XP_006510279.1  zinc finger and BTB domain-containing protein 44 isoform X2

    UniProtKB/TrEMBL
    A0A1L1SQN1
    Conserved Domains (4) summary
    COG5048
    Location:351 → 432
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:384 → 404
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:472 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18228
    Location:15 → 130
    BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)

  3. XM_036154869.1 → XP_036010762.1  zinc finger and BTB domain-containing protein 44 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:351 → 432
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:384 → 404
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18228
    Location:15 → 130
    BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)

  4. XM_006510217.5 → XP_006510280.1  zinc finger and BTB domain-containing protein 44 isoform X3

    UniProtKB/TrEMBL
    A0A1L1SQN1
    Related
    ENSMUSP00000149121.2, ENSMUST00000214585.2
    Conserved Domains (5) summary
    COG5048
    Location:351 → 431
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:471 → 493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18228
    Location:15 → 130
    BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)
    pfam13465
    Location:395 → 420
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177768.2: Suppressed sequence

    Description
    NM_177768.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0A2.2 GenPept UniProtKB/Swiss-Prot:Q8R0A2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous