Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts15provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 15provided by MGI
Primary source: MGI:MGI:2449569
See related: Ensembl:ENSMUSG00000033453 AllianceGenome:MGI:2449569
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active versicanase enzyme. This gene is located adjacent to a related ADAMTS gene (Adamts8) on chromosome 9. [provided by RefSeq, Jul 2016]
Expression: Broad expression in lung adult (RPKM 11.0), limb E14.5 (RPKM 9.9) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 16.45 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (30810451..30833853, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (30899155..30922452, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biallelic variants in ADAMTS15 cause a novel form of distal arthrogryposis.
Title: Biallelic variants in ADAMTS15 cause a novel form of distal arthrogryposis.
spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts15 in mice.
Title: Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin.
Results show that ADAMTS15 and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development
Title: Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex.
these data suggest a role for ADAMTS15 in a wide range of biological processes that are potentially mediated through the processing of versican.
Title: Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236085

Adamts15 (e-PCR), detects polymorphism
- UniSTS:532643

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 15

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024139.2 → NP_001019310.1 A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001019310.1

Status: REVIEWED

Source sequence(s)

AC154722

Consensus CDS

CCDS22945.1

UniProtKB/Swiss-Prot

P59384, Q504Z2, Q91Z56

Related

ENSMUSP00000067022.7, ENSMUST00000065112.7

Conserved Domains (6) summary

smart00209
Location:519 → 571

TSP1; Thrombospondin type 1 repeats

cd04273
Location:218 → 424

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:218 → 427

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:42 → 157

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:683 → 801

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:437 → 506

ADAM_CR; ADAM cysteine-rich
NM_001329420.2 → NP_001316349.1 A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform 2

Status: REVIEWED

Source sequence(s)

AC154722

UniProtKB/Swiss-Prot

P59384

Conserved Domains (5) summary

smart00209
Location:188 → 240

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:352 → 470

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:107 → 174

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:566 → 619

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 93

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
NM_001410620.1 → NP_001397549.1 A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform 2

Status: REVIEWED

Source sequence(s)

AC154722

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

30810451..30833853 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510213.2 → XP_006510276.1 A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform X1

See identical proteins and their annotated locations for XP_006510276.1

Conserved Domains (5) summary

smart00209
Location:188 → 240

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:352 → 470

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:107 → 174

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:566 → 619

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00064
Location:1 → 93

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...