Septin7 septin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Septin7provided by MGI
Official Full Name: septin 7provided by MGI
Primary source: MGI:MGI:1335094
See related: Ensembl:ENSMUSG00000001833 AllianceGenome:MGI:1335094
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdc10; Sept7; E430034N22
Summary: Predicted to enable GTPase activity; identical protein binding activity; and molecular adaptor activity. Acts upstream of or within cortical cytoskeleton organization; mitotic cytokinesis; and plasma membrane bounded cell projection organization. Located in axon terminus; cell body; and septin cytoskeleton. Part of septin complex. Is active in presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 50.7), frontal lobe adult (RPKM 42.1) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 10.25 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (25163287..25219867)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (25251991..25308571)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration.
Title: Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration.
Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal Septin7.
Title: Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal Septin7.
Septin-5 and -7-IgGs: Neurologic, Serologic, and Pathophysiologic Characteristics.
Title: Septin-5 and -7-IgGs: Neurologic, Serologic, and Pathophysiologic Characteristics.
Septin7 is indispensable for proper skeletal muscle architecture and function.
Title: Septin7 is indispensable for proper skeletal muscle architecture and function.
SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development.
Title: SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development.
This study revealed septin7 may potentially play a proapoptotic role in podocyte under diabetic conditions.
Title: Septin 7 mediates high glucose-induced podocyte apoptosis.
SEPT7 regulates gross morphogenesis of the inner ear and maintains the size of the inner ear sensory epithelial area. It does not affect differentiation of hair cells and supporting cells. It exerts its effects at an early developmental stage of the inner ear.
Title: Septin7 regulates inner ear formation at an early developmental stage.
Sept7-deficient T cells failed to complete cytokinesis when prompted by pharmacological activation or cytokines. In contrast, cell division was not dependent on sept7 when cell-cell contacts, such as those with antigen-presenting cells, provided a niche.
Title: A septin requirement differentiates autonomous and contact-facilitated T cell proliferation.
We identified stathmin as a key molecule aiding in septin-independent cytokinesis, demonstrated that stathmin supplementation is sufficient to override cytokinesis failure in SEPT7-null fibroblasts
Title: Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis.
Sept7 provides a physical scaffold for HDAC6 to achieve efficient microtubule deacetylation, thereby negatively regulating microtubule stability to an optimal level for neuritogenesis.
Title: Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:483594

Sept7 (e-PCR), detects polymorphism
- UniSTS:164890

UniSTS:236081 (e-PCR)
- UniSTS:236081

Sept7 (e-PCR), detects polymorphism
- UniSTS:507215

CDC10_514 (e-PCR)
- UniSTS:277079

Results_ER_8_29_95_1_11.seq (e-PCR)
- UniSTS:125579

WI-9389 (e-PCR)
- UniSTS:46571

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of postsynapse	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cortical cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pseudopodium retraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	HDA more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic septin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of septin complex	ISO Inferred from Sequence Orthology more info
located_in septin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in septin filament array	IDA Inferred from Direct Assay more info	PubMed
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
located_in septin ring	IDA Inferred from Direct Assay more info	PubMed
located_in sperm annulus	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: septin-7

Names: CDC10 protein homolog; cell division cycle 10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205367.2 → NP_001192296.1 septin-7 isoform 2

See identical proteins and their annotated locations for NP_001192296.1

Status: VALIDATED

Source sequence(s)

CT025561

UniProtKB/Swiss-Prot

O55131

UniProtKB/TrEMBL

E9Q9F5

Conserved Domains (2) summary

cd01850
Location:46 → 316

CDC_Septin; CDC/Septin GTPase family

PRK12704
Location:336 → 432

PRK12704; phosphodiesterase; Provisional
NM_001359736.1 → NP_001346665.1 septin-7 isoform 3

Status: VALIDATED

Source sequence(s)

CT025561

UniProtKB/TrEMBL

Q8C2A3

Conserved Domains (2) summary

cd01850
Location:1 → 264

CDC_Septin; CDC/Septin GTPase family

PRK12704
Location:284 → 380

PRK12704; phosphodiesterase; Provisional
NM_001359737.2 → NP_001346666.1 septin-7 isoform 3

Status: VALIDATED

Source sequence(s)

CT025561

UniProtKB/TrEMBL

Q8C2A3

Conserved Domains (2) summary

cd01850
Location:1 → 264

CDC_Septin; CDC/Septin GTPase family

PRK12704
Location:284 → 380

PRK12704; phosphodiesterase; Provisional
NM_001359738.1 → NP_001346667.1 septin-7 isoform 3

Status: VALIDATED

Source sequence(s)

CT025561

UniProtKB/TrEMBL

Q8C2A3

Conserved Domains (2) summary

cd01850
Location:1 → 264

CDC_Septin; CDC/Septin GTPase family

PRK12704
Location:284 → 380

PRK12704; phosphodiesterase; Provisional
NM_001421324.1 → NP_001408253.1 septin-7 isoform 4

Status: VALIDATED

Source sequence(s)

CT025561
NM_009859.4 → NP_033989.2 septin-7 isoform 1

Status: VALIDATED

Source sequence(s)

CT025561

Consensus CDS

CCDS40565.1

UniProtKB/TrEMBL

E9Q1G8, E9Q9F5

Related

ENSMUSP00000127641.3, ENSMUST00000165594.4

Conserved Domains (2) summary

cd01850
Location:47 → 317

CDC_Septin; CDC/Septin GTPase family

cl25602
Location:337 → 433

DUF3552; Domain of unknown function (DUF3552)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

25163287..25219867

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244283.1 → XP_030100143.1 septin-7 isoform X3

UniProtKB/TrEMBL

Q8C2A3

Conserved Domains (2) summary

cd01850
Location:1 → 264

CDC_Septin; CDC/Septin GTPase family

PRK12704
Location:284 → 380

PRK12704; phosphodiesterase; Provisional