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Tmem205 transmembrane protein 205 [ Mus musculus (house mouse) ]

Gene ID: 235043, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem205provided by MGI
Official Full Name
transmembrane protein 205provided by MGI
Primary source
MGI:MGI:3045495
See related
Ensembl:ENSMUSG00000040883 AllianceGenome:MGI:3045495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human TMEM205 (transmembrane protein 205). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 421.3), adrenal adult (RPKM 350.4) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A3; 9 7.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21832305..21838831, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21921009..21927535, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin-like 8 Neighboring gene STARR-seq mESC enhancer starr_23526 Neighboring gene STARR-seq mESC enhancer starr_23527 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene coiled-coil domain containing 159 Neighboring gene phospholipid phosphatase related 2 Neighboring gene predicted gene, 45914 Neighboring gene SWIM type zinc finger 7 associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Inoue S, et al. Biochem Biophys Res Commun, 2000 Feb 16. PMID 10679242
  2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC18837

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 205

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253867.1 → NP_001240796.1  transmembrane protein 205 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AI573565, BY790291, CD775257, CN840781
    Conserved Domains (1) summary
    pfam13664
    Location:73 → 172
    DUF4149; Domain of unknown function (DUF4149)

  2. NM_001253868.1 → NP_001240797.1  transmembrane protein 205 isoform 2

    See identical proteins and their annotated locations for NP_001240797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2-5 encode the same protein.
    Source sequence(s)
    AI573565, BY790291, CD775257
    Consensus CDS
    CCDS22913.1
    UniProtKB/Swiss-Prot
    Q91XE8, Q9JME6
    UniProtKB/TrEMBL
    A0A1L1SSA8
    Related
    ENSMUSP00000158874.2, ENSMUST00000238930.2
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 116
    DUF4149; Domain of unknown function (DUF4149)

  3. NM_001253869.1 → NP_001240798.1  transmembrane protein 205 isoform 2

    See identical proteins and their annotated locations for NP_001240798.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a different segment for its 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2-5 encode the same protein.
    Source sequence(s)
    CA326029, CD775257
    Consensus CDS
    CCDS22913.1
    UniProtKB/Swiss-Prot
    Q91XE8, Q9JME6
    UniProtKB/TrEMBL
    A0A1L1SSA8
    Related
    ENSMUSP00000150045.2, ENSMUST00000213698.2
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 116
    DUF4149; Domain of unknown function (DUF4149)

  4. NM_001253870.1 → NP_001240799.1  transmembrane protein 205 isoform 2

    See identical proteins and their annotated locations for NP_001240799.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two different splice sites in the 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2-5 encode the same protein.
    Source sequence(s)
    BY790291, CD775257
    Consensus CDS
    CCDS22913.1
    UniProtKB/Swiss-Prot
    Q91XE8, Q9JME6
    UniProtKB/TrEMBL
    A0A1L1SSA8
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 116
    DUF4149; Domain of unknown function (DUF4149)

  5. NM_178577.5 → NP_848692.2  transmembrane protein 205 isoform 2

    See identical proteins and their annotated locations for NP_848692.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' end, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2-5 encode the same protein.
    Source sequence(s)
    BY790291, CD775257
    Consensus CDS
    CCDS22913.1
    UniProtKB/Swiss-Prot
    Q91XE8, Q9JME6
    UniProtKB/TrEMBL
    A0A1L1SSA8
    Related
    ENSMUSP00000048832.10, ENSMUST00000046831.11
    Conserved Domains (1) summary
    pfam13664
    Location:17 → 116
    DUF4149; Domain of unknown function (DUF4149)

RNA

  1. NR_045606.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses a different splice site in the 5' end and contains an alternate exon, compared to variant 1. This variant is represented as non-coding because translation from the larger, downstream ORF mades the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC166992, BY790291, CD775257

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21832305..21838831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XE8.1 GenPept UniProtKB/Swiss-Prot:Q91XE8

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