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Zfp426 zinc finger protein 426 [ Mus musculus (house mouse) ]

Gene ID: 235028, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp426provided by MGI
Official Full Name
zinc finger protein 426provided by MGI
Primary source
MGI:MGI:1920248
See related
Ensembl:ENSMUSG00000059475 AllianceGenome:MGI:1920248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KRAB1; Zfo61; Znf426; Zfp68-rs1; mKIAA4237; 2900057C04Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF426 (zinc finger protein 426). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.3), CNS E18 (RPKM 3.2) and 26 other tissues See more
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Genomic context

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See Zfp426 in Genome Data Viewer
Location:
9 A3; 9 7.55 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20379845..20404042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20468549..20492746, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 560 Neighboring gene STARR-positive B cell enhancer ABC_E9752 Neighboring gene zinc finger protein 26 Neighboring gene STARR-positive B cell enhancer ABC_E9753 Neighboring gene predicted gene, 23316 Neighboring gene zinc finger protein 266 Neighboring gene predicted gene, 46142

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  3. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Homology

Clone Names

  • KIAA4237, MGC38791

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 426
Names
zinc finger protein 68, related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110309.1 → NP_001103779.1  zinc finger protein 426 isoform 1

    See identical proteins and their annotated locations for NP_001103779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK085144, BC024805
    Consensus CDS
    CCDS40544.1
    UniProtKB/Swiss-Prot
    Q5DTF7, Q8BJ29, Q8CIG1, Q8R1D1
    Related
    ENSMUSP00000079250.7, ENSMUST00000080386.13
    Conserved Domains (6) summary
    smart00349
    Location:39 → 96
    KRAB; krueppel associated box
    COG5048
    Location:328 → 480
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:444 → 464
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:219 → 241
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:39 → 78
    KRAB; KRAB box
    pfam13465
    Location:456 → 481
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001310742.1 → NP_001297671.1  zinc finger protein 426 isoform 2

    See identical proteins and their annotated locations for NP_001297671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate splice sites in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK085144, BC024805, CN725012
    Consensus CDS
    CCDS80962.1
    UniProtKB/TrEMBL
    G5E8Y1
    Related
    ENSMUSP00000126446.2, ENSMUST00000163348.8
    Conserved Domains (6) summary
    smart00349
    Location:39 → 96
    KRAB; krueppel associated box
    COG5048
    Location:327 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:218 → 240
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:39 → 78
    KRAB; KRAB box
    pfam13465
    Location:455 → 480
    zf-H2C2_2; Zinc-finger double domain

  3. NM_146221.4 → NP_666333.1  zinc finger protein 426 isoform 1

    See identical proteins and their annotated locations for NP_666333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK085144
    Consensus CDS
    CCDS40544.1
    UniProtKB/Swiss-Prot
    Q5DTF7, Q8BJ29, Q8CIG1, Q8R1D1
    Related
    ENSMUSP00000111224.3, ENSMUST00000115562.9
    Conserved Domains (6) summary
    smart00349
    Location:39 → 96
    KRAB; krueppel associated box
    COG5048
    Location:328 → 480
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:444 → 464
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:219 → 241
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:39 → 78
    KRAB; KRAB box
    pfam13465
    Location:456 → 481
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20379845..20404042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1D1.1 GenPept UniProtKB/Swiss-Prot:Q8R1D1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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