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Med17 mediator complex subunit 17 [ Mus musculus (house mouse) ]

Gene ID: 234959, updated on 5-Apr-2024

Summary

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Official Symbol
Med17provided by MGI
Official Full Name
mediator complex subunit 17provided by MGI
Primary source
MGI:MGI:2182585
See related
Ensembl:ENSMUSG00000031935 AllianceGenome:MGI:2182585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
77kDa; Crsp6; Trap80; C330002H14Rik
Summary
Predicted to enable nuclear receptor coactivator activity and thyroid hormone receptor binding activity. Acts upstream of or within stem cell population maintenance. Part of mediator complex. Is expressed in female associated reproductive structure; limb mesenchyme; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.0), ovary adult (RPKM 5.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A2; 9 4.74 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15171647..15194576, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15260351..15279906, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23370 Neighboring gene predicted gene, 39293 Neighboring gene predicted gene, 51702 Neighboring gene V-set and transmembrane domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_23372 Neighboring gene RIKEN cDNA 4931406C07 gene Neighboring gene STARR-positive B cell enhancer ABC_E6715 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, D Neighboring gene microRNA 7650

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional activation of lipogenesis by insulin requires phosphorylation of MED17 by CK2. Viscarra JA, et al. Sci Signal, 2017 Feb 21. PMID 28223413, Free PMC Article
  2. Two modes of transcriptional activation at native promoters by NF-kappaB p65. van Essen D, et al. PLoS Biol, 2009 Mar 31. PMID 19338389, Free PMC Article
  3. Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. Tan C, et al. PLoS Genet, 2021 Sep. PMID 34506481, Free PMC Article
  4. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Ge K, et al. Nature, 2002 May 30. PMID 12037571
  5. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 17
Names
CRSP complex subunit 6
cofactor required for Sp1 transcriptional activation, subunit 6 (77kD)
thyroid hormone receptor-associated protein complex 80 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364533.1 → NP_001351462.1  mediator of RNA polymerase II transcription subunit 17 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154296
    Conserved Domains (1) summary
    pfam10156
    Location:123 → 396
    Med17; Subunit 17 of Mediator complex

  2. NM_144933.2 → NP_659182.1  mediator of RNA polymerase II transcription subunit 17 isoform 1

    See identical proteins and their annotated locations for NP_659182.1

    Status: VALIDATED

    Source sequence(s)
    BC020185, CJ078373
    Consensus CDS
    CCDS22834.1
    UniProtKB/Swiss-Prot
    Q8BYS6, Q8VCD5, Q99KQ1
    Related
    ENSMUSP00000034411.9, ENSMUST00000034411.10
    Conserved Domains (1) summary
    pfam10156
    Location:123 → 396
    Med17; Subunit 17 of Mediator complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15171647..15194576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154859.1 → XP_036010752.1  mediator of RNA polymerase II transcription subunit 17 isoform X1

    Conserved Domains (1) summary
    pfam10156
    Location:50 → 316
    Med17; Subunit 17 of Mediator complex
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCD5.1 GenPept UniProtKB/Swiss-Prot:Q8VCD5

Gene LinkOut

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