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Gucy1a2 guanylate cyclase 1, soluble, alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 234889, updated on 14-Apr-2024

Summary

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Official Symbol
Gucy1a2provided by MGI
Official Full Name
guanylate cyclase 1, soluble, alpha 2provided by MGI
Primary source
MGI:MGI:2660877
See related
Ensembl:ENSMUSG00000041624 AllianceGenome:MGI:2660877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330407I18Rik; A230060L24Rik
Summary
Predicted to enable guanylate cyclase activity. Acts upstream of or within positive regulation of nitric oxide mediated signal transduction. Is expressed in several structures, including adrenal gland; nervous system; and urinary system. Orthologous to human GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 2.4), frontal lobe adult (RPKM 2.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Gucy1a2 in Genome Data Viewer
Location:
9 A1; 9 2.14 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (3532349..3905791)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (3532349..3905791)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:3403367-3403668 Neighboring gene STARR-seq mESC enhancer starr_23127 Neighboring gene CWF19 like cell cycle control factor 2 Neighboring gene STARR-seq mESC enhancer starr_23129 Neighboring gene topoisomerase (DNA) II alpha) pseudogene Neighboring gene STARR-seq mESC enhancer starr_23131 Neighboring gene STARR-seq mESC enhancer starr_23133 Neighboring gene STARR-seq mESC enhancer starr_23135 Neighboring gene STARR-seq mESC enhancer starr_23136 Neighboring gene STARR-seq mESC enhancer starr_23138 Neighboring gene STARR-seq mESC enhancer starr_23139 Neighboring gene STARR-seq mESC enhancer starr_23140 Neighboring gene STARR-seq mESC enhancer starr_23142 Neighboring gene STARR-seq mESC enhancer starr_23143 Neighboring gene STARR-seq mESC enhancer starr_23144 Neighboring gene STARR-seq mESC enhancer starr_23145 Neighboring gene STARR-seq mESC enhancer starr_23147 Neighboring gene STARR-seq mESC enhancer starr_23148 Neighboring gene STARR-seq mESC enhancer starr_23152 Neighboring gene predicted gene, 45957 Neighboring gene aldose reductase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. circ-Gucy1a2 Protects Mice from Cerebral Ischemia-Reperfusion Injury by Attenuating Neuronal Apoptosis and Mitochondrial Membrane Potential Loss. Wang F, et al. J Invest Surg, 2023 Dec. PMID 37277119
  2. Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Neitz A, et al. Cereb Cortex, 2014 Jul. PMID 23448871
  3. Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Neitz A, et al. Eur J Neurosci, 2011 May. PMID 21410795
  4. More than a retrograde messenger: nitric oxide needs two cGMP pathways to induce hippocampal long-term potentiation. Taqatqeh F, et al. J Neurosci, 2009 Jul 22. PMID 19625524, Free PMC Article
  5. Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice. Vanneste G, et al. J Physiol, 2007 Nov 1. PMID 17717014, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. circ-Gucy1a2 Protects Mice from Cerebral Ischemia-Reperfusion Injury by Attenuating Neuronal Apoptosis and Mitochondrial Membrane Potential Loss.
    Title: circ-Gucy1a2 Protects Mice from Cerebral Ischemia-Reperfusion Injury by Attenuating Neuronal Apoptosis and Mitochondrial Membrane Potential Loss.
  2. These data suggests a novel physiological role for PDE5 in restricting the effects of NOS3/sGC/PKG signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC]
    Title: Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.
  3. The aim of this study was to investigate the role of Gucy1a2 in nitrergic regulation of gastric motility in male and female Gucy1a2 knock-out mice.
    Title: Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice.
  4. Requirement of both alpha-2 and alpha-1 guanylate cyclases for signaling in long-term potentiation (LTP) indicates the existence of two distinct nitric oxide/cGMP-mediated pathways, which have to work in concert for expression of LTP.
    Title: Long-term potentiation in the visual cortex requires both nitric oxide receptor guanylyl cyclases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of nitric oxide mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of nitric oxide mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxygen levels IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanylate cyclase soluble subunit alpha-2
NP_001028494.1
XP_011240663.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033322.3 → NP_001028494.1  guanylate cyclase soluble subunit alpha-2

    See identical proteins and their annotated locations for NP_001028494.1

    Status: VALIDATED

    Source sequence(s)
    AC118473, AC122444, AC156642
    Consensus CDS
    CCDS40526.1
    UniProtKB/TrEMBL
    F8VQK3
    Related
    ENSMUSP00000111398.2, ENSMUST00000115733.3
    Conserved Domains (4) summary
    smart00044
    Location:483 → 672
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:512 → 696
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:157 → 268
    HNOB; Haem-NO-binding
    pfam07701
    Location:314 → 501
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    3532349..3905791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242361.2 → XP_011240663.1  guanylate cyclase soluble subunit alpha-2 isoform X1

    Conserved Domains (3) summary
    pfam00211
    Location:428 → 612
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07701
    Location:230 → 417
    HNOBA; Heme NO binding associated
    pfam07700
    Location:68 → 184
    HNOB; Haem-NO-binding
Nucleotide Protein Strain
Heading Accession and Version

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