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Piezo1 piezo-type mechanosensitive ion channel component 1 [ Mus musculus (house mouse) ]

Gene ID: 234839, updated on 22-Apr-2024

Summary

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Official Symbol
Piezo1provided by MGI
Official Full Name
piezo-type mechanosensitive ion channel component 1provided by MGI
Primary source
MGI:MGI:3603204
See related
Ensembl:ENSMUSG00000014444 AllianceGenome:MGI:3603204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam38a; mKIAA0233; 9630020g22
Summary
Enables identical protein binding activity and mechanosensitive cation channel activity. Involved in positive regulation of myotube differentiation. Acts upstream of or within cation transport; detection of mechanical stimulus; and regulation of membrane potential. Located in plasma membrane. Is expressed in several structures, including hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1 and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 39.8), ovary adult (RPKM 31.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 71.31 cM
Exon count:
53
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123208437..123278068, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122481698..122551329, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene snail family zinc finger 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124993848-124994115 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124994651-124994852 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124997832-124998091 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124999099-124999282 Neighboring gene ring finger protein 166 Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene STARR-seq mESC enhancer starr_22950 Neighboring gene predicted gene, 26497 Neighboring gene STARR-positive B cell enhancer ABC_E1108 Neighboring gene STARR-positive B cell enhancer ABC_E6699 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125080544-125080815 Neighboring gene predicted gene, 34847 Neighboring gene STARR-positive B cell enhancer ABC_E8270 Neighboring gene chromatin licensing and DNA replication factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue. Nottmeier C, et al. Sci Rep, 2023 Jun 12. PMID 37308580, Free PMC Article
  2. Jatrorrhizine inhibits Piezo1 activation and reduces vascular inflammation in endothelial cells. Hong T, et al. Biomed Pharmacother, 2023 Jul. PMID 37105072
  3. The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation. Zhu J, et al. Proc Natl Acad Sci U S A, 2023 May 2. PMID 37098060, Free PMC Article
  4. Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species. Wang Q, et al. Biochem Biophys Res Commun, 2023 Apr 16. PMID 36841099
  5. Developmental function of Piezo1 in mouse submandibular gland morphogenesis. Pokharel E, et al. Histochem Cell Biol, 2023 Jun. PMID 36814002

See all (161) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.
    Title: Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.
  2. The PIEZO1/miR-155-5p/GDF6/SMAD2/3 signaling axis is involved in inducing the occurrence and progression of osteoarthritis under excessive mechanical stress.
    Title: The PIEZO1/miR-155-5p/GDF6/SMAD2/3 signaling axis is involved in inducing the occurrence and progression of osteoarthritis under excessive mechanical stress.
  3. Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca[2+] influx.
    Title: Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca(2+) influx.
  4. Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption.
    Title: Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption.
  5. Expression patterns of Piezo1 in the developing mouse forebrain.
    Title: Expression patterns of Piezo1 in the developing mouse forebrain.
  6. Examination of the mechanism of Piezo ion channel in 5-HT synthesis in the enterochromaffin cell and its association with gut motility.
    Title: Examination of the mechanism of Piezo ion channel in 5-HT synthesis in the enterochromaffin cell and its association with gut motility.
  7. Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx.
    Title: Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx.
  8. Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake.
    Title: Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake.
  9. Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.
    Title: Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.
  10. Roles of the mechanosensitive ion channel Piezo1 in the renal podocyte injury of experimental hypertensive nephropathy.
    Title: Roles of the mechanosensitive ion channel Piezo1 in the renal podocyte injury of experimental hypertensive nephropathy.
Submit: New GeneRIF Correction See all GeneRIFs (150)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mechanosensitive monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mechanosensitive monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within detection of mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic cation transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
piezo-type mechanosensitive ion channel component 1
Names
family with sequence similarity 38, member A
protein PIEZO1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037298.1 → NP_001032375.1  piezo-type mechanosensitive ion channel component 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114917
    Consensus CDS
    CCDS52695.1
    UniProtKB/Swiss-Prot
    E2JF22
    UniProtKB/TrEMBL
    E9PUQ9
    Related
    ENSMUSP00000089777.6, ENSMUST00000067252.14
    Conserved Domains (2) summary
    pfam12166
    Location:2126 → 2544
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1229 → 1452
    PIEZO; Piezo

  2. NM_001357349.1 → NP_001344278.1  piezo-type mechanosensitive ion channel component 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114917
    Consensus CDS
    CCDS90474.1
    UniProtKB/Swiss-Prot
    E2JF22
    UniProtKB/TrEMBL
    F7AC58
    Related
    ENSMUSP00000114584.3, ENSMUST00000156333.9
    Conserved Domains (2) summary
    pfam12166
    Location:2127 → 2545
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1230 → 1453
    PIEZO; Piezo

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123208437..123278068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530954.2 → XP_006531017.2  piezo-type mechanosensitive ion channel component 1 isoform X2

    UniProtKB/Swiss-Prot
    E2JF22
    Conserved Domains (2) summary
    pfam12166
    Location:2121 → 2539
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1224 → 1447
    PIEZO; Piezo

  2. XM_006530956.2 → XP_006531019.2  piezo-type mechanosensitive ion channel component 1 isoform X3

    UniProtKB/Swiss-Prot
    E2JF22
    Conserved Domains (2) summary
    pfam12166
    Location:2098 → 2516
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1225 → 1424
    PIEZO; Piezo

  3. XM_006530953.2 → XP_006531016.2  piezo-type mechanosensitive ion channel component 1 isoform X1

    UniProtKB/Swiss-Prot
    E2JF22
    Conserved Domains (2) summary
    pfam12166
    Location:2122 → 2540
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1225 → 1448
    PIEZO; Piezo

  4. XM_006530959.3 → XP_006531022.1  piezo-type mechanosensitive ion channel component 1 isoform X5

    UniProtKB/TrEMBL
    Q80XT7
    Conserved Domains (2) summary
    pfam12166
    Location:1397 → 1815
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:500 → 723
    PIEZO; Piezo

  5. XM_011248372.2 → XP_011246674.1  piezo-type mechanosensitive ion channel component 1 isoform X6

    UniProtKB/TrEMBL
    Q6ZQF9
    Conserved Domains (2) summary
    pfam12166
    Location:976 → 1394
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:79 → 302
    PIEZO; Piezo

  6. XM_006530957.3 → XP_006531020.2  piezo-type mechanosensitive ion channel component 1 isoform X4

    UniProtKB/Swiss-Prot
    E2JF22
    Conserved Domains (2) summary
    pfam12166
    Location:2122 → 2173
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1225 → 1448
    PIEZO; Piezo
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2JF22.1 GenPept UniProtKB/Swiss-Prot:E2JF22

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