Il17c interleukin 17C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il17cprovided by MGI
Official Full Name: interleukin 17Cprovided by MGI
Primary source: MGI:MGI:2446486
See related: Ensembl:ENSMUSG00000046108 AllianceGenome:MGI:2446486
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-17C
Summary: Enables cytokine activity. Acts upstream of or within neutrophil differentiation and positive regulation of cytokine production involved in inflammatory response. Located in extracellular space. Orthologous to human IL17C (interleukin 17C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 1.3), thymus adult (RPKM 0.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 71.03 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (123147912..123150820)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (122422020..122423639)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-17C neutralization protects the kidney against acute injury and chronic injury.
Title: IL-17C neutralization protects the kidney against acute injury and chronic injury.
IL-17C has a pathogenic role in kidney ischemia/reperfusion injury.
Title: IL-17C has a pathogenic role in kidney ischemia/reperfusion injury.
IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.
Title: IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations.
IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology.
Title: IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.
Authors found that IL-17c can effectively activate OM cells through the release of ATP. In the longer term, intranasal chronic instillations of IL-17c increased the cellular dynamics of the epithelium and promoted immune cells infiltrations.
Title: IL-17c is involved in olfactory mucosa responses to Poly(I:C) mimicking virus presence.
Our results indicate that Chlamydia pneumoniae infection promotes vascular smooth muscle cell migration via c-Fos/IL-17C signaling.
Title: Chlamydia pneumoniae infection promotes vascular smooth muscle cell migration via c-Fos/interleukin-17C signaling.
These data indicate that the IL-17C/IL-17RE axis promotes the recruitment of neutrophils without affecting the recovery of alveolar macrophages in the acute phase of S. pneumoniae lung infection.
Title: Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute Streptococcus pneumoniae Pneumonia.
results are the first demonstrating the protective role of IL-17C in Acute graft-vs.-host disease (aGVHD) by promoting intestinal barrier functions and Treg differentiation in a MHC fully mismatched murine aGVHD model. IL-17C may serve as a novel biomarker and potential therapeutic target for aGVHD.
Title: IL-17C Mitigates Murine Acute Graft-vs.-Host Disease by Promoting Intestinal Barrier Functions and Treg Differentiation.
In mouse models of crescentic GN (nephrotoxic nephritis) and pristane-induced lupus nephritis, deficiency in IL-17C significantly ameliorated the course of GN in terms of renal tissue injury and kidney function. IL-17C is produced by renal tissue-resident cells, but not by lymphocytes. IL-17C promotes TH17 cell responses and immune-mediated kidney disease via IL-17RE expressed on CD4(+) TH17 cells.
Title: IL-17C/IL-17 Receptor E Signaling in CD4(+) T Cells Promotes T(H)17 Cell-Driven Glomerular Inflammation.
Study utilizing human skin samples, cultured primary human and mouse keratinocytes, and mouse disease models indicates that IL-17C is a central mediator of skin inflammation beyond psoriasis and is relevant in particular in atopic dermatitis.
Title: Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-17C

Names: cytokine CX2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145834.4 → NP_665833.4 interleukin-17C

Status: VALIDATED

Source sequence(s)

BC145853

Consensus CDS

CCDS90473.1

UniProtKB/Swiss-Prot

A6H6F0, Q8K4C5

UniProtKB/TrEMBL

A0A0R4J0P4

Related

ENSMUSP00000056008.4, ENSMUST00000050963.4

Conserved Domains (1) summary

pfam06083
Location:88 → 176

IL17; Interleukin-17

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

123147912..123150820

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153977.1 → XP_036009870.1 interleukin-17C isoform X1

UniProtKB/Swiss-Prot

A6H6F0, Q8K4C5

Conserved Domains (1) summary

pfam06083
Location:108 → 196

IL17; Interleukin-17