U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc38a8 solute carrier family 38, member 8 [ Mus musculus (house mouse) ]

Gene ID: 234788, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Slc38a8provided by MGI
Official Full Name
solute carrier family 38, member 8provided by MGI
Primary source
MGI:MGI:2685433
See related
Ensembl:ENSMUSG00000034224 AllianceGenome:MGI:2685433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm587
Summary
Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to act upstream of or within amino acid transport and sodium ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SLC38A8 (solute carrier family 38 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8 E1; 8 67.8 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120206313..120228503, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119479574..119501698, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene oxidative stress induced growth inhibitor 1 Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene predicted gene, 53462 Neighboring gene STARR-seq mESC enhancer starr_22850 Neighboring gene membrane-bound transcription factor peptidase, site 1 Neighboring gene STARR-seq mESC enhancer starr_22853 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122082621-122082922 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122087691-122087878 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122087910-122088232 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122093859-122094132 Neighboring gene hydroxysteroid dehydrogenase like 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication. Liu H, et al. PLoS Pathog, 2023 Feb. PMID 36735752, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication.
    Title: Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (6)  1 citation

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC113805

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
solute carrier family 38 member 8
Names
amino acid transporter SLC38A8
putative sodium-coupled neutral amino acid transporter 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009950.2 → NP_001009950.1  solute carrier family 38 member 8

    See identical proteins and their annotated locations for NP_001009950.1

    Status: VALIDATED

    Source sequence(s)
    AC140672, AC166781
    Consensus CDS
    CCDS22706.1
    UniProtKB/Swiss-Prot
    Q5HZH7
    Related
    ENSMUSP00000038438.9, ENSMUST00000036748.15
    Conserved Domains (2) summary
    COG0814
    Location:23 → 429
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:23 → 421
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    120206313..120228503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248368.2 → XP_011246670.1  solute carrier family 38 member 8 isoform X1

    See identical proteins and their annotated locations for XP_011246670.1

    Conserved Domains (1) summary
    cl00456
    Location:1 → 322
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HZH7.1 GenPept UniProtKB/Swiss-Prot:Q5HZH7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous