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Fcsk fucose kinase [ Mus musculus (house mouse) ]

Gene ID: 234730, updated on 5-Mar-2024

Summary

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Official Symbol
Fcskprovided by MGI
Official Full Name
fucose kinaseprovided by MGI
Primary source
MGI:MGI:1916071
See related
Ensembl:ENSMUSG00000033703 AllianceGenome:MGI:1916071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fuk; 1110046B12Rik
Summary
Enables fucokinase activity. Involved in carbohydrate phosphorylation. Is expressed in axial skeleton and cranium. Orthologous to human FCSK (fucose kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 21.4), duodenum adult (RPKM 12.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 57.79 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111609088..111629120, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110882456..110902488, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_22685 Neighboring gene predicted gene, 22193 Neighboring gene STARR-positive B cell enhancer ABC_E11398 Neighboring gene component of oligomeric golgi complex 4 Neighboring gene STARR-positive B cell enhancer ABC_E9743 Neighboring gene STARR-positive B cell enhancer ABC_E8264 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene predicted gene, 26132 Neighboring gene predicted gene, 46052

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and expression of murine enzymes involved in the salvage pathway of GDP-L-fucose. Niittymäki J, et al. Eur J Biochem, 2004 Jan. PMID 14686921
  2. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cloning, expression and tissue distribution of murine L-fucokinase and GDP-L-fucose pyrophosphorylase
    Title: Cloning and expression of murine enzymes involved in the salvage pathway of GDP-L-fucose.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fucokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fucokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP-L-fucose salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GDP-L-fucose salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
L-fucose kinase
Names
fucokinase
mFLJ00241 protein
NP_758487.2
XP_006530983.1
XP_017168235.1
XP_030099371.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172283.3 → NP_758487.2  L-fucose kinase

    See identical proteins and their annotated locations for NP_758487.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK161763, AK164340, AY223865
    Consensus CDS
    CCDS22666.1
    UniProtKB/Swiss-Prot
    Q7TMC8, Q7TSB1, Q8C7W3, Q8CI18
    Related
    ENSMUSP00000039271.7, ENSMUST00000041382.7
    Conserved Domains (3) summary
    COG2605
    Location:707 → 996
    COG2605; Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]
    pfam07959
    Location:97 → 495
    Fucokinase; L-fucokinase
    cl00160
    Location:374 → 431
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

RNA

  1. NR_052009.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132945, AK161763, AK164340
    Related
    ENSMUST00000212971.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111609088..111629120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312746.2 → XP_017168235.1  L-fucose kinase isoform X1

    Conserved Domains (2) summary
    PRK13412
    Location:512 → 895
    fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
    pfam07959
    Location:1 → 343
    Fucokinase; L-fucokinase

  2. XM_030243511.1 → XP_030099371.1  L-fucose kinase isoform X3

    Conserved Domains (2) summary
    PRK13412
    Location:212 → 595
    fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
    pfam07959
    Location:2 → 43
    Fucokinase; L-fucokinase

  3. XM_006530920.2 → XP_006530983.1  L-fucose kinase isoform X2

    Conserved Domains (2) summary
    PRK13412
    Location:336 → 719
    fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
    pfam07959
    Location:32 → 167
    Fucokinase; L-fucokinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMC8.1 GenPept UniProtKB/Swiss-Prot:Q7TMC8

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