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Ces2e carboxylesterase 2E [ Mus musculus (house mouse) ]

Gene ID: 234673, updated on 11-Apr-2024

Summary

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Official Symbol
Ces2eprovided by MGI
Official Full Name
carboxylesterase 2Eprovided by MGI
Primary source
MGI:MGI:2443170
See related
Ensembl:ENSMUSG00000031886 AllianceGenome:MGI:2443170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ces5; 9030624L02Rik
Summary
Enables carboxylic ester hydrolase activity. Predicted to be involved in prostaglandin metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in alimentary system; liver; and liver lobe. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 206.8), large intestine adult (RPKM 204.6) and 3 other tissues See more
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Genomic context

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Location:
8 D3; 8 53.04 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105652892..105661304)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104926260..104934672)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33218 Neighboring gene carboxylesterase 2D, pseudogene Neighboring gene predicted gene, 33141 Neighboring gene carboxylesterase 2 pseudogene Neighboring gene carboxylesterase 2F Neighboring gene carboxylesterase 2G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. Stok JE, et al. J Biol Chem, 2004 Jul 9. PMID 15123619
  2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables retinyl-palmitate esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables trans-permethrin hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pyrethroid hydrolase Ces2e
Names
carboxylesterase 5
carboxylic ester hydrolase
NP_001157228.1
NP_766347.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163756.1 → NP_001157228.1  pyrethroid hydrolase Ces2e precursor

    See identical proteins and their annotated locations for NP_001157228.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC166833, AK077248, BB806111
    Consensus CDS
    CCDS22588.1
    UniProtKB/Swiss-Prot
    Q8BK48, Q8BM97, Q8VC02
    Related
    ENSMUSP00000105037.3, ENSMUST00000109410.4
    Conserved Domains (2) summary
    COG0657
    Location:128 → 231
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:30 → 538
    COesterase; Carboxylesterase family

  2. NM_172759.3 → NP_766347.1  pyrethroid hydrolase Ces2e precursor

    See identical proteins and their annotated locations for NP_766347.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC166833, AK077248
    Consensus CDS
    CCDS22588.1
    UniProtKB/Swiss-Prot
    Q8BK48, Q8BM97, Q8VC02
    Related
    ENSMUSP00000034355.5, ENSMUST00000034355.11
    Conserved Domains (2) summary
    COG0657
    Location:128 → 231
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:30 → 538
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105652892..105661304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BK48.1 GenPept UniProtKB/Swiss-Prot:Q8BK48

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