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Cnot1 CCR4-NOT transcription complex, subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 234594, updated on 11-Apr-2024

Summary

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Official Symbol
Cnot1provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 1provided by MGI
Primary source
MGI:MGI:2442402
See related
Ensembl:ENSMUSG00000036550 AllianceGenome:MGI:2442402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D830048B13; 6030411K04Rik
Summary
Predicted to enable armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Involved in regulation of stem cell population maintenance and trophectodermal cell differentiation. Located in P-body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 29.9), placenta adult (RPKM 21.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cnot1 in Genome Data Viewer
Location:
8 D1; 8 47.18 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96445559..96534741, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95718931..95808113, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene N-myc downstream regulated gene 4 Neighboring gene predicted gene, 51585 Neighboring gene SET domain containing 6 Neighboring gene predicted gene, 26493 Neighboring gene microRNA 7073 Neighboring gene predicted gene, 26265 Neighboring gene STARR-seq mESC enhancer starr_22394 Neighboring gene RIKEN cDNA 4930513N10 gene Neighboring gene STARR-positive B cell enhancer ABC_E1374 Neighboring gene STARR-positive B cell enhancer ABC_E5033 Neighboring gene STARR-seq mESC enhancer starr_22403 Neighboring gene Sin3-associated polypeptide 18B Neighboring gene predicted gene, 31805

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner. Mohamed HMA, et al. RNA Biol, 2022. PMID 35510877, Free PMC Article
  2. The CCR4-NOT Deadenylase Complex Maintains Adipocyte Identity. Takahashi A, et al. Int J Mol Sci, 2019 Oct 24. PMID 31652943, Free PMC Article
  3. The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation. Takahashi A, et al. Life Sci Alliance, 2020 May. PMID 32238456, Free PMC Article
  4. A CCR4-NOT Transcription Complex, Subunit 1, CNOT1, Variant Associated with Holoprosencephaly. Kruszka P, et al. Am J Hum Genet, 2019 May 2. PMID 31006510, Free PMC Article
  5. Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7. Faraji F, et al. PLoS Genet, 2016 Jan. PMID 26807845, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner.
    Title: CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner.
  2. CCR4-NOT complex-mediated regulation of gene expression has significant effects on proper adipocyte function, including insulin sensitivity, lipid metabolism, and control of body temperature.
    Title: The CCR4-NOT Deadenylase Complex Maintains Adipocyte Identity.
  3. Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis
    Title: Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.
  4. These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
    Title: Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
  5. Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs.
    Title: Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7843, MGC189870, MGC189936

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytoplasmic mRNA processing body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in trophectodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 1
Names
CCR4-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205226.2 → NP_001192155.1  CCR4-NOT transcription complex subunit 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113951, AC127300
    Consensus CDS
    CCDS85589.1
    UniProtKB/TrEMBL
    A0A1D5RMJ8, B2RXR3
    Related
    ENSMUSP00000148807.2, ENSMUST00000211887.2
    Conserved Domains (5) summary
    pfam04054
    Location:1991 → 2346
    Not1; CCR4-Not complex component, Not1
    pfam12842
    Location:1382 → 1527
    DUF3819; Domain of unknown function (DUF3819)
    pfam16415
    Location:1081 → 1305
    CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
    pfam16417
    Location:813 → 997
    CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
    pfam16418
    Location:498 → 654
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  2. NM_001372351.1 → NP_001359280.1  CCR4-NOT transcription complex subunit 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113951, AC127300
    UniProtKB/TrEMBL
    B2RXR3
    Conserved Domains (2) summary
    COG5103
    Location:834 → 2370
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam16418
    Location:500 → 656
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  3. NM_001372353.1 → NP_001359282.1  CCR4-NOT transcription complex subunit 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113951, AC127300
    Consensus CDS
    CCDS90442.1
    UniProtKB/TrEMBL
    B2RXR3
    Related
    ENSMUSP00000096073.5, ENSMUST00000098473.11
    Conserved Domains (2) summary
    COG5103
    Location:840 → 2369
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam16418
    Location:500 → 656
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  4. NM_153164.4 → NP_694804.3  CCR4-NOT transcription complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_694804.3

    Status: VALIDATED

    Source sequence(s)
    AC113951, AC127300
    Consensus CDS
    CCDS57635.1
    UniProtKB/TrEMBL
    B2RXR3, B7ZWL1
    Related
    ENSMUSP00000063565.9, ENSMUST00000068452.10
    Conserved Domains (5) summary
    pfam04054
    Location:1993 → 2301
    Not1; CCR4-Not complex component, Not1
    pfam12842
    Location:1384 → 1529
    DUF3819; Domain of unknown function (DUF3819)
    pfam16415
    Location:1083 → 1307
    CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
    pfam16417
    Location:815 → 999
    CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
    pfam16418
    Location:500 → 656
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  5. NM_178078.3 → NP_835179.1  CCR4-NOT transcription complex subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_835179.1

    Status: VALIDATED

    Source sequence(s)
    AC113951, AC127300
    UniProtKB/TrEMBL
    B2RXR3
    Conserved Domains (5) summary
    pfam04054
    Location:1993 → 2348
    Not1; CCR4-Not complex component, Not1
    pfam12842
    Location:1384 → 1529
    DUF3819; Domain of unknown function (DUF3819)
    pfam16415
    Location:1083 → 1307
    CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
    pfam16417
    Location:815 → 999
    CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
    pfam16418
    Location:500 → 656
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    96445559..96534741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530870.2 → XP_006530933.1  CCR4-NOT transcription complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    B2RXR3
    Conserved Domains (2) summary
    COG5103
    Location:840 → 2376
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam16418
    Location:500 → 656
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  2. XM_036153965.1 → XP_036009858.1  CCR4-NOT transcription complex subunit 1 isoform X5

    UniProtKB/TrEMBL
    B2RXR3
    Conserved Domains (2) summary
    COG5103
    Location:834 → 2363
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam16418
    Location:500 → 656
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  3. XM_036153964.1 → XP_036009857.1  CCR4-NOT transcription complex subunit 1 isoform X4

    UniProtKB/Swiss-Prot
    B2RY28, Q3UPB7, Q6ZQ08, Q8BSB4, Q8BXB2, Q8C0H2, Q8K3D8
    UniProtKB/TrEMBL
    B2RXR3
    Conserved Domains (2) summary
    COG5103
    Location:839 → 2368
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam16418
    Location:500 → 656
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  4. XM_006530871.3 → XP_006530934.1  CCR4-NOT transcription complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    B2RXR3
    Conserved Domains (2) summary
    COG5103
    Location:839 → 2375
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam16418
    Location:500 → 656
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

  5. XM_006530872.3 → XP_006530935.1  CCR4-NOT transcription complex subunit 1 isoform X3

    UniProtKB/TrEMBL
    B2RXR3
    Conserved Domains (2) summary
    COG5103
    Location:835 → 2371
    CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
    pfam16418
    Location:500 → 656
    CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

RNA

  1. XR_003947260.1 RNA Sequence

  2. XR_001778431.3 RNA Sequence

    Related
    ENSMUST00000213006.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQ08.2 GenPept UniProtKB/Swiss-Prot:Q6ZQ08

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