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Ndrg4 N-myc downstream regulated gene 4 [ Mus musculus (house mouse) ]

Gene ID: 234593, updated on 21-Apr-2024

Summary

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Official Symbol
Ndrg4provided by MGI
Official Full Name
N-myc downstream regulated gene 4provided by MGI
Primary source
MGI:MGI:2384590
See related
Ensembl:ENSMUSG00000036564 AllianceGenome:MGI:2384590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ndr4; SMAP-8; Ndr1-rs; D8Bwg1337e
Summary
Involved in several processes, including regulation of endocytic recycling; vesicle docking; and visual learning. Located in cell projection membrane and cytoplasm. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and retina. Orthologous to human NDRG4 (NDRG family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 385.8), cerebellum adult (RPKM 322.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D1; 8 47.12 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96403602..96441584)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95676974..95714956)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42037 Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene predicted gene, 51585 Neighboring gene SET domain containing 6 Neighboring gene CCR4-NOT transcription complex, subunit 1 Neighboring gene predicted gene, 26493

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons. Vaes N, et al. Neurogastroenterol Motil, 2017 Sep. PMID 28524415
  2. Uterine Expression of NDRG4 Is Induced by Estrogen and Up-Regulated during Embryo Implantation Process in Mice. Yang Q, et al. PLoS One, 2016. PMID 27175791, Free PMC Article
  3. Postnatal lethality and abnormal development of foregut and spleen in Ndrg4 mutant mice. Qu X, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26801554, Free PMC Article
  4. N-myc downstream-regulated gene 4, up-regulated by tumor necrosis factor-α and nuclear factor kappa B, aggravates cardiac ischemia/reperfusion injury by inhibiting reperfusion injury salvage kinase pathway. Xing Y, et al. Basic Res Cardiol, 2016 Mar. PMID 26780215
  5. NDRG4 is required for cell cycle progression and survival in glioblastoma cells. Schilling SH, et al. J Biol Chem, 2009 Sep 11. PMID 19592488, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein
    Title: NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons.
  2. NDRG4 might play an important role during early pregnancy.
    Title: Uterine Expression of NDRG4 Is Induced by Estrogen and Up-Regulated during Embryo Implantation Process in Mice.
  3. up-regulation of NDRG4 aggravates myocardial ischemia/reperfusion injury by inhibiting activation of the RISK pathway
    Title: N-myc downstream-regulated gene 4, up-regulated by tumor necrosis factor-α and nuclear factor kappa B, aggravates cardiac ischemia/reperfusion injury by inhibiting reperfusion injury salvage kinase pathway.
  4. Availability of the conditional allele for Ndrg4 should facilitate further detailed analyses of the potential roles of Ndrg4 in gut development, nervous system and immune system.
    Title: Postnatal lethality and abnormal development of foregut and spleen in Ndrg4 mutant mice.
  5. Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition.
    Title: Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition.
  6. NDRG4 contributes to the maintenance of intracerebral BDNF levels within the normal range
    Title: NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia.
  7. NDRG4 is required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and GBM cells
    Title: NDRG4 is required for cell cycle progression and survival in glioblastoma cells.
  8. These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain.
    Title: Differential expression patterns of NDRG family proteins in the central nervous system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7067

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration involved in heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle docking IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein NDRG4
Names
N-myc downstream regulated 1, related sequence
N-myc downstream-regulated gene 4 protein
protein Ndr4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195006.2 → NP_001181935.1  protein NDRG4 isoform A

    See identical proteins and their annotated locations for NP_001181935.1

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Consensus CDS
    CCDS57634.1
    UniProtKB/Swiss-Prot
    Q6ZPW3, Q8BTG7, Q923D7
    Related
    ENSMUSP00000072883.8, ENSMUST00000073139.14
    Conserved Domains (1) summary
    pfam03096
    Location:8 → 290
    Ndr; Ndr family

  2. NM_001372421.1 → NP_001359350.1  protein NDRG4 isoform C

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:60 → 342
    Ndr; Ndr family

  3. NM_001372423.1 → NP_001359352.1  protein NDRG4 isoform C

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Consensus CDS
    CCDS90441.1
    Related
    ENSMUSP00000036226.8, ENSMUST00000041318.14
    Conserved Domains (1) summary
    pfam03096
    Location:60 → 342
    Ndr; Ndr family

  4. NM_001372425.1 → NP_001359354.1  protein NDRG4 isoform D

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:60 → 342
    Ndr; Ndr family

  5. NM_001372426.1 → NP_001359355.1  protein NDRG4 isoform D

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:60 → 342
    Ndr; Ndr family

  6. NM_001372427.1 → NP_001359356.1  protein NDRG4 isoform E

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 322
    Ndr; Ndr family

  7. NM_001372428.1 → NP_001359357.1  protein NDRG4 isoform E

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 322
    Ndr; Ndr family

  8. NM_001372429.1 → NP_001359358.1  protein NDRG4 isoform F

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 322
    Ndr; Ndr family

  9. NM_001372430.1 → NP_001359359.1  protein NDRG4 isoform G

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 306
    Ndr; Ndr family

  10. NM_001372431.1 → NP_001359360.1  protein NDRG4 isoform H

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:8 → 289
    Ndr; Ndr family

  11. NM_001372432.1 → NP_001359361.1  protein NDRG4 isoform I

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:8 → 289
    Ndr; Ndr family

  12. NM_001372433.1 → NP_001359362.1  protein NDRG4 isoform J

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:8 → 274
    Ndr; Ndr family

  13. NM_001372434.1 → NP_001359363.1  protein NDRG4 isoform K

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:8 → 269
    Ndr; Ndr family

  14. NM_001372435.1 → NP_001359364.1  protein NDRG4 isoform L

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Conserved Domains (1) summary
    pfam03096
    Location:8 → 261
    Ndr; Ndr family

  15. NM_145602.4 → NP_663577.1  protein NDRG4 isoform B

    See identical proteins and their annotated locations for NP_663577.1

    Status: VALIDATED

    Source sequence(s)
    AC113951
    Consensus CDS
    CCDS22565.1
    UniProtKB/Swiss-Prot
    Q8BTG7
    Related
    ENSMUSP00000079495.8, ENSMUST00000080666.8
    Conserved Domains (1) summary
    pfam03096
    Location:8 → 290
    Ndr; Ndr family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    96403602..96441584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTG7.1 GenPept UniProtKB/Swiss-Prot:Q8BTG7

Gene LinkOut

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