Cpne2 copine II [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpne2provided by MGI
Official Full Name: copine IIprovided by MGI
Primary source: MGI:MGI:2387578
See related: Ensembl:ENSMUSG00000034361 AllianceGenome:MGI:2387578
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3322401K10Rik
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in colon adult (RPKM 18.5), subcutaneous fat pad adult (RPKM 17.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 46.55 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (95259299..95297157)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94532674..94570529)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The second C2-domain of copine-2 is responsible for calcium-dependent membrane association.
Title: The second C2-domain of copine-2, copine-6 and copine-7 is responsible for their calcium-dependent membrane association.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Mit182 (e-PCR), detects polymorphism
- UniSTS:131391

STS-F03992 (e-PCR)
- UniSTS:33492

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in clathrin-coated endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: copine-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153507.2 → NP_705727.1 copine-2

See identical proteins and their annotated locations for NP_705727.1

Status: REVIEWED

Source sequence(s)

BC031801

Consensus CDS

CCDS22543.1

UniProtKB/Swiss-Prot

P59108, Q8K1D7

UniProtKB/TrEMBL

A0A0R4J1D0

Related

ENSMUSP00000045755.3, ENSMUST00000048653.10

Conserved Domains (3) summary

cd04047
Location:155 → 267

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:24 → 141

C2A_Copine; C2 domain first repeat in Copine

cl00057
Location:279 → 530

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

95259299..95297157

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312732.3 → XP_017168221.1 copine-2 isoform X1

Conserved Domains (3) summary

cd04047
Location:155 → 267

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:24 → 141

C2A_Copine; C2 domain first repeat in Copine

cl00057
Location:279 → 353

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...