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Sugp2 SURP and G patch domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 234373, updated on 5-Mar-2024

Summary

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Official Symbol
Sugp2provided by MGI
Official Full Name
SURP and G patch domain containing 2provided by MGI
Primary source
MGI:MGI:2678085
See related
Ensembl:ENSMUSG00000036054 AllianceGenome:MGI:2678085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sfrs14; Srsf14; mKIAA0365
Summary
Predicted to enable RNA binding activity. Predicted to be involved in RNA processing. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nuclear body. Is expressed in mandible; maxilla; orbito-sphenoid; and rib. Orthologous to human SUGP2 (SURP and G-patch domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 32.9), whole brain E14.5 (RPKM 19.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Sugp2 in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70686838..70715755)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70234188..70263105)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10504 Neighboring gene transmembrane protein 161A Neighboring gene solute carrier family 25, member 42 Neighboring gene STARR-positive B cell enhancer ABC_E1103 Neighboring gene armadillo repeat containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E8239 Neighboring gene predicted gene, 38427 Neighboring gene homer scaffolding protein 3 Neighboring gene DEAD box helicase 49

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. Sampson ND, et al. Gene, 2003 Feb 13. PMID 12594045
  2. Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Mozhui K, et al. Behav Genet, 2007 Jan. PMID 17131200
  3. Splicing factor TRA2B is required for neural progenitor survival. Roberts JM, et al. J Comp Neurol, 2014 Feb 1. PMID 23818142, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC66544

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SURP and G-patch domain-containing protein 2
Names
arginine/serine-rich-splicing factor 14
putative splicing factor, arginine/serine-rich 14
serine/arginine-rich splicing factor 14
splicing factor, arginine/serine-rich 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168290.2 → NP_001161762.1  SURP and G-patch domain-containing protein 2

    See identical proteins and their annotated locations for NP_001161762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC124327, AF518875, AK042293, BE981284
    Consensus CDS
    CCDS22362.1
    UniProtKB/Swiss-Prot
    Q6PG19, Q80UY8, Q8BY32, Q8CFM0, Q8CH09
    Related
    ENSMUSP00000128029.2, ENSMUST00000164403.8
    Conserved Domains (3) summary
    pfam01585
    Location:997 → 1040
    G-patch; G-patch domain
    pfam01805
    Location:769 → 819
    Surp; Surp module
    cl02715
    Location:571 → 619
    Surp; Surp module

  2. NM_172755.4 → NP_766343.3  SURP and G-patch domain-containing protein 2

    See identical proteins and their annotated locations for NP_766343.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC124327, AF518875, AK042293
    Consensus CDS
    CCDS22362.1
    UniProtKB/Swiss-Prot
    Q6PG19, Q80UY8, Q8BY32, Q8CFM0, Q8CH09
    Related
    ENSMUSP00000091167.5, ENSMUST00000093458.11
    Conserved Domains (3) summary
    pfam01585
    Location:997 → 1040
    G-patch; G-patch domain
    pfam01805
    Location:769 → 819
    Surp; Surp module
    cl02715
    Location:571 → 619
    Surp; Surp module

RNA

  1. NR_165051.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124327

  2. NR_165052.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124327

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70686838..70715755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153946.1 → XP_036009839.1  SURP and G-patch domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6PG19, Q80UY8, Q8BY32, Q8CFM0, Q8CH09
    Conserved Domains (3) summary
    pfam01585
    Location:997 → 1040
    G-patch; G-patch domain
    pfam01805
    Location:769 → 819
    Surp; Surp module
    cl02715
    Location:571 → 619
    Surp; Surp module

  2. XM_036153947.1 → XP_036009840.1  SURP and G-patch domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6PG19, Q80UY8, Q8BY32, Q8CFM0, Q8CH09
    Conserved Domains (3) summary
    pfam01585
    Location:997 → 1040
    G-patch; G-patch domain
    pfam01805
    Location:769 → 819
    Surp; Surp module
    cl02715
    Location:571 → 619
    Surp; Surp module

RNA

  1. XR_004934810.1 RNA Sequence

  2. XR_004934811.1 RNA Sequence

  3. XR_004934812.1 RNA Sequence

  4. XR_004934815.1 RNA Sequence

  5. XR_004934813.1 RNA Sequence

  6. XR_004934814.1 RNA Sequence

  7. XR_004934807.1 RNA Sequence

  8. XR_004934808.1 RNA Sequence

  9. XR_004934809.1 RNA Sequence

  10. XR_004934816.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CH09.2 GenPept UniProtKB/Swiss-Prot:Q8CH09

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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