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Naf1 nuclear assembly factor 1 ribonucleoprotein [ Mus musculus (house mouse) ]

Gene ID: 234344, updated on 5-Mar-2024

Summary

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Official Symbol
Naf1provided by MGI
Official Full Name
nuclear assembly factor 1 ribonucleoproteinprovided by MGI
Primary source
MGI:MGI:2682306
See related
Ensembl:ENSMUSG00000014907 AllianceGenome:MGI:2682306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm174
Summary
Predicted to enable identical protein binding activity and telomerase RNA binding activity. Involved in RNA stabilization. Predicted to be located in nucleoplasm. Predicted to be part of sno(s)RNA-containing ribonucleoprotein complex. Orthologous to human NAF1 (nuclear assembly factor 1 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 9.7), ovary adult (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.1; 8 33.18 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (67312594..67343216)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (66859943..66890564)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene neuropeptide Y receptor Y1 Neighboring gene STARR-seq mESC enhancer starr_21679 Neighboring gene STARR-positive B cell enhancer ABC_E8235 Neighboring gene RNA binding motif protein 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21680 Neighboring gene STARR-seq mESC enhancer starr_21683 Neighboring gene predicted gene, 39185 Neighboring gene predicted gene, 25275 Neighboring gene STARR-seq mESC enhancer starr_21684 Neighboring gene STARR-seq mESC enhancer starr_21685 Neighboring gene STARR-seq mESC enhancer starr_21686 Neighboring gene STARR-seq mESC enhancer starr_21687 Neighboring gene FGFR1 oncogene partner 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema. Stanley SE, et al. Sci Transl Med, 2016 Aug 10. PMID 27510903, Free PMC Article
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in box H/ACA snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in box H/ACA snoRNP assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
  
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in snoRNA guided rRNA pseudouridine synthesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in telomerase RNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in telomerase holoenzyme complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of sno(s)RNA-containing ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sno(s)RNA-containing ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
H/ACA ribonucleoprotein complex non-core subunit NAF1
Names
nuclear assembly factor 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163564.1 → NP_001157036.1  H/ACA ribonucleoprotein complex non-core subunit NAF1

    Status: VALIDATED

    Source sequence(s)
    AC116731, AK144735
    Consensus CDS
    CCDS52562.1
    UniProtKB/TrEMBL
    E9QJT2
    Related
    ENSMUSP00000112640.2, ENSMUST00000118009.2
    Conserved Domains (2) summary
    pfam04410
    Location:281 → 429
    Gar1; Gar1/Naf1 RNA binding region
    pfam05454
    Location:55 → 125
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    67312594..67343216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153916.1 → XP_036009809.1  H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform X1

    Conserved Domains (2) summary
    PHA03269
    Location:53 → 130
    PHA03269; envelope glycoprotein C; Provisional
    PRK12323
    Location:10 → 212
    PRK12323; DNA polymerase III subunit gamma/tau

RNA

  1. XR_003947254.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UMQ8.2 GenPept UniProtKB/Swiss-Prot:Q3UMQ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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