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Ddx60 DExD/H box helicase 60 [ Mus musculus (house mouse) ]

Gene ID: 234311, updated on 21-Apr-2024

Summary

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Official Symbol
Ddx60provided by MGI
Official Full Name
DExD/H box helicase 60provided by MGI
Primary source
MGI:MGI:2384570
See related
Ensembl:ENSMUSG00000037921 AllianceGenome:MGI:2384570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830118M07
Summary
Enables RNA binding activity. Acts upstream of or within defense response to virus. Located in cytoplasm. Is expressed in lens. Orthologous to human DDX60 (DExD/H-box helicase 60). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
8 B3.1; 8 31.51 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (62381155..62491278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61928073..62037704)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene palladin, cytoskeletal associated protein Neighboring gene RIKEN cDNA 4930512H18 gene Neighboring gene lysyl-tRNA synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21603 Neighboring gene STARR-seq mESC enhancer starr_21604 Neighboring gene annexin A10 Neighboring gene STARR-seq mESC enhancer starr_21605 Neighboring gene predicted gene 2961

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Circ-Ddx60 contributes to the antihypertrophic memory of exercise hypertrophic preconditioning. Zhu Y, et al. J Adv Res, 2023 Apr. PMID 35718079, Free PMC Article
  2. Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses. Goubau D, et al. Eur J Immunol, 2015 Dec. PMID 26457795, Free PMC Article
  3. DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation. Oshiumi H, et al. Cell Rep, 2015 May 26. PMID 25981042
  4. DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. Miyashita M, et al. Mol Cell Biol, 2011 Sep. PMID 21791617, Free PMC Article
  5. Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. Fujimoto M, et al. J Biol Chem, 2008 Oct 31. PMID 18755693, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ-Ddx60 contributes to the antihypertrophic memory of exercise hypertrophic preconditioning.
    Title: Circ-Ddx60 contributes to the antihypertrophic memory of exercise hypertrophic preconditioning.
  2. overexpression of DDX60 did not potentiate IFN induction
    Title: Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.
  3. Results define DDX60 as a sentinel for cytoplasmic antiviral response, which is counteracted by virus-mediated EGF receptor activation.
    Title: DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation.
  4. DDX60 is a novel antiviral helicase promoting RIG-I-like receptor-mediated signaling.
    Title: DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC19297

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX60
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
NP_001280712.1
XP_006509456.1
XP_006509459.1
XP_011240516.1
XP_017168186.1
XP_017168187.1
XP_036009806.1
XP_036009807.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293783.2 → NP_001280712.1  probable ATP-dependent RNA helicase DDX60

    See identical proteins and their annotated locations for NP_001280712.1

    Status: VALIDATED

    Source sequence(s)
    AC139846, AC144858
    Consensus CDS
    CCDS52556.2
    UniProtKB/TrEMBL
    E9PZQ1, G3X9F7
    Related
    ENSMUSP00000070741.8, ENSMUST00000070631.15
    Conserved Domains (3) summary
    smart00490
    Location:1252 → 1328
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:760 → 951
    DEXDc; DEAD-like helicases superfamily
    pfam00270
    Location:766 → 920
    DEAD; DEAD/DEAH box helicase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    62381155..62491278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509393.3 → XP_006509456.1  probable ATP-dependent RNA helicase DDX60 isoform X1

    UniProtKB/TrEMBL
    E9PZQ1
    Conserved Domains (2) summary
    COG4581
    Location:608 → 1318
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cd18025
    Location:713 → 885
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

  2. XM_017312697.3 → XP_017168186.1  probable ATP-dependent RNA helicase DDX60 isoform X5

    Conserved Domains (1) summary
    cd18025
    Location:761 → 938
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

  3. XM_006509396.3 → XP_006509459.1  probable ATP-dependent RNA helicase DDX60 isoform X6

    Conserved Domains (1) summary
    cd18025
    Location:761 → 938
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

  4. XM_011242214.3 → XP_011240516.1  probable ATP-dependent RNA helicase DDX60 isoform X3

    Conserved Domains (1) summary
    cd18025
    Location:761 → 938
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

  5. XM_036153914.1 → XP_036009807.1  probable ATP-dependent RNA helicase DDX60 isoform X4

    Conserved Domains (1) summary
    cd18025
    Location:761 → 938
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

  6. XM_017312698.3 → XP_017168187.1  probable ATP-dependent RNA helicase DDX60 isoform X7

    Conserved Domains (1) summary
    cl28899
    Location:761 → 858
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  7. XM_036153913.1 → XP_036009806.1  probable ATP-dependent RNA helicase DDX60 isoform X2

    Conserved Domains (2) summary
    COG4581
    Location:356 → 967
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cd18025
    Location:357 → 534
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

RNA

  1. XR_001778429.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081215.1: Suppressed sequence

    Description
    NM_001081215.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_144928.1: Suppressed sequence

    Description
    NM_144928.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version

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