Cbr4 carbonyl reductase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cbr4provided by MGI
Official Full Name: carbonyl reductase 4provided by MGI
Primary source: MGI:MGI:2384567
See related: Ensembl:ENSMUSG00000031641 AllianceGenome:MGI:2384567
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A730083J17Rik
Summary: Predicted to enable several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Predicted to be involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Orthologous to human CBR4 (carbonyl reductase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 7.8), heart adult (RPKM 7.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.1; 8 31.18 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (61940768..61956534)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (61487734..61503500)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables NAD(P)H dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables NADPH dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables quinone binding	IBA Inferred from Biological aspect of Ancestor more info
enables quinone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
part_of oxidoreductase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 3-oxoacyl-[acyl-carrier-protein] reductase

Names: 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; KAR beta subunit; carbonyl reductase family member 4; quinone reductase CBR4

NP_663570.2

EC 1.1.1.100

EC 1.6.5.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145595.2 → NP_663570.2 3-oxoacyl-[acyl-carrier-protein] reductase

See identical proteins and their annotated locations for NP_663570.2

Status: VALIDATED

Source sequence(s)

AK043313, AK150763

Consensus CDS

CCDS40349.1

UniProtKB/Swiss-Prot

Q3UBY4, Q8BXV1, Q91VT4

Related

ENSMUSP00000034058.7, ENSMUST00000034058.14

Conserved Domains (2) summary

PRK05653
Location:1 → 234

fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

cl21454
Location:3 → 232

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins