Dkk4 dickkopf WNT signaling pathway inhibitor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dkk4provided by MGI
Official Full Name: dickkopf WNT signaling pathway inhibitor 4provided by MGI
Primary source: MGI:MGI:2385299
See related: Ensembl:ENSMUSG00000031535 AllianceGenome:MGI:2385299
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dkk-4
Summary: Predicted to enable co-receptor binding activity and receptor antagonist activity. Acts upstream of or within Wnt signaling pathway and negative regulation of hair follicle placode formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human DKK4 (dickkopf WNT signaling pathway inhibitor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 11.42 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (23113701..23117563)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (22623685..22628018)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/beta-catenin negative feedback pathway.
Title: Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/β-catenin negative feedback pathway.
the dynamic state of Dkk4 itself and its interaction with Lrp6 modulates Wnt function during Meibomian gland development, with a novel limitation of Dkk4 action by proteolytic cleavage.
Title: Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.
sweat gland development shows a relay of regulatory steps initiated by Wnt/beta-catenin - itself modulated by Dkk4 - with subsequent participation of Eda and Shh pathways.
Title: Involvement of Wnt, Eda and Shh at defined stages of sweat gland development.
These results showed that Dkk4 functions as an inhibitor of osteoblastogenesis through Wnt/beta-catenin signaling, providing new insights into the relationship between Wnt/beta-catenin signaling and Dkk4 in bone formation.
Title: The effects of Dickkopf-4 on the proliferation, differentiation, and apoptosis of osteoblasts.
It would appear that deregulation of the WNT pathway by overexpression of DKK4 may further impair WNT signaling and lead to Anorectal malformations.
Title: Genome-wide copy number variation study in anorectal malformations.
Dkk4 affects an auxiliary pathway for Eda-independent development of secondary hair
Title: Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair.
Microarray profiling of genes differentially regulated by short exposure to recombinant Eda-A1 in embryonic eda(-/-) skin explants, was performed to identify direct targets of ectodysplasin pathway.
Title: Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes.
Dkk4 acts in a negative feedback loop to attenuate canonical Wnt signaling and may facilitate a switch to the non-canonical Wnt planar cell polarity pathway that is involved in cell movements during morphogenesis.
Title: The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Dkk4 (e-PCR), detects polymorphism
- UniSTS:471824

Dkk4 (e-PCR), detects polymorphism
- UniSTS:527123

Dkk4 (e-PCR), detects polymorphism
- UniSTS:508435

Dkk4 (e-PCR), detects polymorphism
- UniSTS:508436

Dkk4 (e-PCR), detects polymorphism
- UniSTS:506850

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables co-receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of hair follicle placode formation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dickkopf-related protein 4

Names: dickkopf homolog 4; dickkopf-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145592.2 → NP_663567.1 dickkopf-related protein 4 precursor

See identical proteins and their annotated locations for NP_663567.1

Status: PROVISIONAL

Source sequence(s)

AC121835

Consensus CDS

CCDS22180.1

UniProtKB/Swiss-Prot

Q8VEJ3

Related

ENSMUSP00000033936.7, ENSMUST00000033936.8

Conserved Domains (2) summary

pfam06607
Location:145 → 202

Prokineticin

pfam04706
Location:41 → 91

Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

23113701..23117563

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509098.4 → XP_006509161.1 dickkopf-related protein 4 isoform X1

See identical proteins and their annotated locations for XP_006509161.1

UniProtKB/Swiss-Prot

Q8VEJ3

Conserved Domains (2) summary

pfam06607
Location:145 → 202

Prokineticin

pfam04706
Location:41 → 91

Dickkopf_N; Dickkopf N-terminal cysteine-rich region