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Tpte transmembrane phosphatase with tensin homology [ Mus musculus (house mouse) ]

Gene ID: 234129, updated on 8-Feb-2024

Summary

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Official Symbol
Tpteprovided by MGI
Official Full Name
transmembrane phosphatase with tensin homologyprovided by MGI
Primary source
MGI:MGI:2446460
See related
Ensembl:ENSMUSG00000031481 AllianceGenome:MGI:2446460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vsp; Pten2
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including dephosphorylation; phosphatidylinositol 3-kinase signaling; and regulation of protein kinase B signaling. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in brain; eye; future spinal cord; surface ectoderm; and testis. Orthologous to several human genes including TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.2), kidney adult (RPKM 0.2) and 6 other tissues See more
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Genomic context

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See Tpte in Genome Data Viewer
Location:
8 A2; 8 11.2 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22773457..22861432)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22283315..22371418)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 36 Neighboring gene ribosomal protein L30, pseudogene 2 Neighboring gene thrombospondin, type I, domain 1 Neighboring gene predicted gene, 46035 Neighboring gene solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 Neighboring gene RIKEN cDNA 1810012K16 gene Neighboring gene STARR-positive B cell enhancer ABC_E6625

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Polarized PtdIns(4,5)P(2) distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility. Kawai T, et al. Proc Natl Acad Sci U S A, 2019 Dec 17. PMID 31776261, Free PMC Article
  2. A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells. Mishra RR, et al. PLoS One, 2011. PMID 22164291, Free PMC Article
  3. Mus musculus-microRNA-449a ameliorates neuropathic pain by decreasing the level of KCNMA1 and TRPA1, and increasing the level of TPTE. Lu S, et al. Mol Med Rep, 2017 Jul. PMID 28498403
  4. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. Tapparel C, et al. Gene, 2003 Dec 24. PMID 14659893
  5. The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family. Guipponi M, et al. Hum Genet, 2001 Dec. PMID 11810268

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mmumiR449a may ameliorate neuropathic pain by decreasing the activity of the channel proteins TRPA1 and KCNMA1 and increasing the levels of TPTE.
    Title: Mus musculus-microRNA-449a ameliorates neuropathic pain by decreasing the level of KCNMA1 and TRPA1, and increasing the level of TPTE.
  2. the TPIP splice-variant (TPIP-C2) mRNA is expressed in human and mouse tissues and strongly inhibits cell growth in HeLa cells
    Title: A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC130293

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane phosphatase with tensin homology
NP_954866.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199257.3 → NP_954866.2  transmembrane phosphatase with tensin homology

    See identical proteins and their annotated locations for NP_954866.2

    Status: VALIDATED

    Source sequence(s)
    AC121933, AC140326
    Consensus CDS
    CCDS22173.1
    UniProtKB/TrEMBL
    G5E8H5, Q3KNE1
    Related
    ENSMUSP00000076435.2, ENSMUST00000077194.2
    Conserved Domains (2) summary
    smart00404
    Location:413 → 478
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:529 → 663
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22773457..22861432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181851.3: Suppressed sequence

    Description
    NM_181851.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_199258.1: Suppressed sequence

    Description
    NM_199258.1: This RefSeq was permanently suppressed because it contains the wrong CDS.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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