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Arglu1 arginine and glutamate rich 1 [ Mus musculus (house mouse) ]

Gene ID: 234023, updated on 5-Mar-2024

Summary

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Official Symbol
Arglu1provided by MGI
Official Full Name
arginine and glutamate rich 1provided by MGI
Primary source
MGI:MGI:2442985
See related
Ensembl:ENSMUSG00000040459 AllianceGenome:MGI:2442985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C130008N12; 9430010O03Rik
Summary
Predicted to be located in cytosol. Predicted to be active in mitochondrion and nucleoplasm. Is expressed in 4th ventricle lateral recess and lateral ventricle choroid plexus. Orthologous to human ARGLU1 (arginine and glutamate rich 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 64.7), CNS E14 (RPKM 55.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A1.1; 8 3.57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (8716307..8741818, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (8666297..8690550, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31463 Neighboring gene STARR-seq mESC enhancer starr_20662 Neighboring gene ephrin B2 Neighboring gene RIKEN cDNA 4921522P10 gene Neighboring gene STARR-seq mESC enhancer starr_20669 Neighboring gene microRNA 7654 Neighboring gene IKAROS family zinc finger 5 pseudogene Neighboring gene predicted gene, 39127 Neighboring gene STARR-seq mESC enhancer starr_20671

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development. Magomedova L, et al. Nucleic Acids Res, 2019 Apr 8. PMID 30698747, Free PMC Article
  2. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis.
    Title: Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arginine and glutamate-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176849.3 → NP_789819.2  arginine and glutamate-rich protein 1

    See identical proteins and their annotated locations for NP_789819.2

    Status: VALIDATED

    Source sequence(s)
    BC029219, BU514203, BY756892, CB528163
    Consensus CDS
    CCDS40215.1
    UniProtKB/Swiss-Prot
    Q3UL36, Q80XJ0
    Related
    ENSMUSP00000039493.9, ENSMUST00000048545.10
    Conserved Domains (1) summary
    pfam15346
    Location:128 → 267
    ARGLU; Arginine and glutamate-rich 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    8716307..8741818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508760.5 → XP_006508823.1  arginine and glutamate-rich protein 1 isoform X2

    Conserved Domains (1) summary
    pfam15346
    Location:80 → 219
    ARGLU; Arginine and glutamate-rich 1

  2. XM_006508759.5 → XP_006508822.1  arginine and glutamate-rich protein 1 isoform X1

    Conserved Domains (1) summary
    pfam15346
    Location:110 → 249
    ARGLU; Arginine and glutamate-rich 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UL36.2 GenPept UniProtKB/Swiss-Prot:Q3UL36

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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