Fbxl19 F-box and leucine-rich repeat protein 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxl19provided by MGI
Official Full Name: F-box and leucine-rich repeat protein 19provided by MGI
Primary source: MGI:MGI:3039600
See related: Ensembl:ENSMUSG00000030811 AllianceGenome:MGI:3039600
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbl19; 6030430O11
Summary: Predicted to enable several functions, including transcription coregulator activity; unmethylated CpG binding activity; and zinc ion binding activity. Acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in early conceptus and genitourinary system. Orthologous to human FBXL19 (F-box and leucine rich repeat protein 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 27.2), CNS E11.5 (RPKM 26.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.71 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127343059..127368655)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127743887..127769483)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective role of FBXL19 in Streptococcus pneumoniae-induced lung injury in pneumonia immature mice.
Title: Protective role of FBXL19 in Streptococcus pneumoniae-induced lung injury in pneumonia immature mice.
FBXL19 and CDK-Mediator support long-range interactions between silent gene promoters that rely on FBXL19 for their induction during differentiation and gene regulatory elements.
Title: CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions.
these data validate Fbxl19 as a direct miR-26 target and support its role as a regulator of adipogenesis that functions downstream from the miR-26 familywithin the APC lineage
Title: miR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19.
Removing the CpG island-binding domain of FBXL19 results in a failure to induce developmental genes during ES cell differentiation.
Title: FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.
analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes
Title: Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation.
The results demonstrate that Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B monoubiquitination.
Title: Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B mono-ubiquitination.
SCF(FBXL19) targets RhoA for its disposal, a process regulated by Erk2.
Title: A new mechanism of RhoA ubiquitination and degradation: roles of SCF(FBXL19) E3 ligase and Erk2.
Data indicate that overexpression of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migration.
Title: SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation.
The fundamental observation was that FBXL19 attenuated IL-33-mediated activity by removing ST2L, but not sST2 or IL-1R1, on the cell surface.
Title: F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables unmethylated CpG binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein demethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box/LRR-repeat protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374793.1 → NP_001361722.1 F-box/LRR-repeat protein 19 isoform 2

Status: VALIDATED

Source sequence(s)

AC149222

Consensus CDS

CCDS90334.1

Related

ENSMUSP00000145616.2, ENSMUST00000206893.2

Conserved Domains (6) summary

cd09293
Location:403 → 602

AMN1; Antagonist of mitotic exit network protein 1

PHA03247
Location:172 → 365

PHA03247; large tegument protein UL36; Provisional

sd00034
Location:423 → 446

LRR_AMN1; leucine-rich repeat [structural motif]

cd15645
Location:67 → 128

PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)

pfam02008
Location:30 → 57

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:361 → 402

F-box-like
NM_001421761.1 → NP_001408690.1 F-box/LRR-repeat protein 19 isoform 3

Status: VALIDATED

Source sequence(s)

AC149222
NM_001421762.1 → NP_001408691.1 F-box/LRR-repeat protein 19 isoform 4

Status: VALIDATED

Source sequence(s)

AC149222
NM_001421763.1 → NP_001408692.1 F-box/LRR-repeat protein 19 isoform 5

Status: VALIDATED

Source sequence(s)

AC149222
NM_001421764.1 → NP_001408693.1 F-box/LRR-repeat protein 19 isoform 5

Status: VALIDATED

Source sequence(s)

AC149222
NM_172748.3 → NP_766336.2 F-box/LRR-repeat protein 19 isoform 1

See identical proteins and their annotated locations for NP_766336.2

Status: VALIDATED

Source sequence(s)

AC149222

Consensus CDS

CCDS21877.1

UniProtKB/Swiss-Prot

Q6PB97, Q7TSH0, Q8BIB4

Related

ENSMUSP00000033081.8, ENSMUST00000033081.14

Conserved Domains (6) summary

cd09293
Location:446 → 645

AMN1; Antagonist of mitotic exit network protein 1

PHA03247
Location:176 → 408

PHA03247; large tegument protein UL36; Provisional

sd00034
Location:466 → 489

LRR_AMN1; leucine-rich repeat [structural motif]

cd15645
Location:67 → 128

PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)

pfam02008
Location:30 → 57

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:404 → 445

F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

127343059..127368655

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153020.1 → XP_036008913.1 F-box/LRR-repeat protein 19 isoform X1

Conserved Domains (5) summary

cd09293
Location:468 → 667

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:488 → 511

LRR_AMN1; leucine-rich repeat [structural motif]

cd15645
Location:89 → 150

PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)

pfam02008
Location:52 → 79

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:426 → 467

F-box-like
XM_036153021.1 → XP_036008914.1 F-box/LRR-repeat protein 19 isoform X2

Conserved Domains (5) summary

cd09293
Location:425 → 624

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:445 → 468

LRR_AMN1; leucine-rich repeat [structural motif]

cd15645
Location:89 → 150

PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)

pfam02008
Location:52 → 79

zf-CXXC; CXXC zinc finger domain

pfam12937
Location:383 → 424

F-box-like