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Atxn2l ataxin 2-like [ Mus musculus (house mouse) ]

Gene ID: 233871, updated on 5-Mar-2024

Summary

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Official Symbol
Atxn2lprovided by MGI
Official Full Name
ataxin 2-likeprovided by MGI
Primary source
MGI:MGI:2446242
See related
Ensembl:ENSMUSG00000032637 AllianceGenome:MGI:2446242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A2D; A2LG; A2RP; A2lp; Atxnl2
Summary
Predicted to enable RNA binding activity. Predicted to be involved in stress granule assembly. Predicted to be located in cytosol; membrane; and nuclear speck. Predicted to be active in cytoplasmic stress granule. Orthologous to human ATXN2L (ataxin 2 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 219.2), thymus adult (RPKM 135.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.09 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126090880..126106991, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126491708..126507819, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133630590-133630777 Neighboring gene predicted gene, 46001 Neighboring gene Tu translation elongation factor, mitochondrial Neighboring gene RIKEN cDNA 4930456A14 gene Neighboring gene STARR-positive B cell enhancer ABC_E555 Neighboring gene STARR-positive B cell enhancer ABC_E10474 Neighboring gene STARR-positive B cell enhancer ABC_E8209 Neighboring gene STARR-seq mESC enhancer starr_20151 Neighboring gene eukaryotic translation initiation factor 3, subunit C Neighboring gene predicted gene, 24596 Neighboring gene predicted gene, 25579

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mid-Gestation lethality of Atxn2l-Ablated Mice. Key J, et al. Int J Mol Sci, 2020 Jul 20. PMID 32698485, Free PMC Article
  2. Specific expression and alternative splicing of mouse genes during spermatogenesis. Li Q, et al. Mol Omics, 2020 Jun 1. PMID 32211685
  3. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Cassar PA, et al. EMBO Rep, 2015 Oct. PMID 26265008, Free PMC Article
  4. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
  5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specific expression and alternative splicing of mouse genes during spermatogenesis.
    Title: Specific expression and alternative splicing of mouse genes during spermatogenesis.
  2. Mid-Gestation lethality of Atxn2l-Ablated Mice.
    Title: Mid-Gestation lethality of Atxn2l-Ablated Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ataxin-2-like protein
Names
ataxin 2 related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347658.2 → NP_001334587.1  ataxin-2-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125322
    Consensus CDS
    CCDS85413.1
    UniProtKB/TrEMBL
    E9Q5Q0, Q3TGG2
    Related
    ENSMUSP00000132959.2, ENSMUST00000167759.8

  2. NM_001361487.2 → NP_001348416.1  ataxin-2-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125322
    UniProtKB/TrEMBL
    Q3TYH7
    Conserved Domains (4) summary
    pfam06741
    Location:262 → 324
    LsmAD; LsmAD domain
    pfam14438
    Location:121 → 194
    SM-ATX; Ataxin 2 SM domain
    cl25764
    Location:749 → 950
    PAT1; Topoisomerase II-associated protein PAT1
    cl26464
    Location:334 → 940
    Atrophin-1; Atrophin-1 family

  3. NM_183020.3 → NP_898841.1  ataxin-2-like protein isoform 1

    See identical proteins and their annotated locations for NP_898841.1

    Status: VALIDATED

    Source sequence(s)
    AC125322
    Consensus CDS
    CCDS21831.1
    UniProtKB/Swiss-Prot
    Q7TQH0, Q80XN9, Q8K059
    UniProtKB/TrEMBL
    E9Q5Q0
    Related
    ENSMUSP00000035415.9, ENSMUST00000040202.15
    Conserved Domains (2) summary
    pfam06741
    Location:262 → 324
    LsmAD; LsmAD domain
    pfam14438
    Location:120 → 188
    SM-ATX; Ataxin 2 SM domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126090880..126106991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507725.3 → XP_006507788.1  ataxin-2-like protein isoform X5

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (4) summary
    PHA03247
    Location:334 → 940
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:262 → 324
    LsmAD; LsmAD domain
    pfam09770
    Location:830 → 1035
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:118 → 194
    SM-ATX; Ataxin 2 SM domain

  2. XM_030242516.2 → XP_030098376.1  ataxin-2-like protein isoform X4

    Conserved Domains (5) summary
    PHA03247
    Location:547 → 1073
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:207 → 532
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:262 → 324
    LsmAD; LsmAD domain
    pfam09770
    Location:749 → 950
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:118 → 194
    SM-ATX; Ataxin 2 SM domain

  3. XM_006507721.3 → XP_006507784.1  ataxin-2-like protein isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPL0
    Related
    ENSMUSP00000146023.2, ENSMUST00000206577.2
    Conserved Domains (5) summary
    PHA03247
    Location:588 → 1031
    PHA03247; large tegument protein UL36; Provisional
    COG5180
    Location:207 → 532
    PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
    pfam06741
    Location:262 → 324
    LsmAD; LsmAD domain
    pfam09770
    Location:749 → 950
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:118 → 194
    SM-ATX; Ataxin 2 SM domain

  4. XM_006507723.3 → XP_006507786.1  ataxin-2-like protein isoform X3

    See identical proteins and their annotated locations for XP_006507786.1

    UniProtKB/TrEMBL
    Q3TYH7
    Conserved Domains (4) summary
    PHA03247
    Location:401 → 946
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:262 → 324
    LsmAD; LsmAD domain
    pfam09770
    Location:755 → 956
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:118 → 194
    SM-ATX; Ataxin 2 SM domain

  5. XM_006507722.3 → XP_006507785.1  ataxin-2-like protein isoform X3

    See identical proteins and their annotated locations for XP_006507785.1

    UniProtKB/TrEMBL
    Q3TYH7
    Conserved Domains (4) summary
    PHA03247
    Location:401 → 946
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:262 → 324
    LsmAD; LsmAD domain
    pfam09770
    Location:755 → 956
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:118 → 194
    SM-ATX; Ataxin 2 SM domain

  6. XM_006507720.4 → XP_006507783.1  ataxin-2-like protein isoform X1

    See identical proteins and their annotated locations for XP_006507783.1

    Conserved Domains (4) summary
    PHA03247
    Location:401 → 946
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:262 → 324
    LsmAD; LsmAD domain
    pfam09770
    Location:755 → 956
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:118 → 194
    SM-ATX; Ataxin 2 SM domain

  7. XM_011241775.2 → XP_011240077.1  ataxin-2-like protein isoform X1

    See identical proteins and their annotated locations for XP_011240077.1

    Conserved Domains (4) summary
    PHA03247
    Location:401 → 946
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:262 → 324
    LsmAD; LsmAD domain
    pfam09770
    Location:755 → 956
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:118 → 194
    SM-ATX; Ataxin 2 SM domain

  8. XM_006507728.3 → XP_006507791.1  ataxin-2-like protein isoform X17

    Conserved Domains (2) summary
    PHA03247
    Location:3 → 499
    PHA03247; large tegument protein UL36; Provisional
    PRK14971
    Location:427 → 502
    PRK14971; DNA polymerase III subunit gamma/tau

  9. XM_030242522.2 → XP_030098382.1  ataxin-2-like protein isoform X11

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (4) summary
    PHA03247
    Location:248 → 854
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:176 → 238
    LsmAD; LsmAD domain
    pfam09770
    Location:663 → 864
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:32 → 108
    SM-ATX; Ataxin 2 SM domain

  10. XM_030242521.2 → XP_030098381.1  ataxin-2-like protein isoform X11

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (4) summary
    PHA03247
    Location:248 → 854
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:176 → 238
    LsmAD; LsmAD domain
    pfam09770
    Location:663 → 864
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:32 → 108
    SM-ATX; Ataxin 2 SM domain

  11. XM_030242519.2 → XP_030098379.1  ataxin-2-like protein isoform X9

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (5) summary
    PHA03247
    Location:248 → 854
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:782 → 1006
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam06741
    Location:176 → 238
    LsmAD; LsmAD domain
    pfam09770
    Location:663 → 864
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:32 → 108
    SM-ATX; Ataxin 2 SM domain

  12. XM_030242520.2 → XP_030098380.1  ataxin-2-like protein isoform X10

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (3) summary
    PHA03247
    Location:315 → 860
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:176 → 238
    LsmAD; LsmAD domain
    pfam14438
    Location:35 → 108
    SM-ATX; Ataxin 2 SM domain

  13. XM_036153014.1 → XP_036008907.1  ataxin-2-like protein isoform X10

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (3) summary
    PHA03247
    Location:315 → 860
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:176 → 238
    LsmAD; LsmAD domain
    pfam14438
    Location:35 → 108
    SM-ATX; Ataxin 2 SM domain

  14. XM_030242518.2 → XP_030098378.1  ataxin-2-like protein isoform X8

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (4) summary
    PHA03247
    Location:315 → 860
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:176 → 238
    LsmAD; LsmAD domain
    pfam09770
    Location:669 → 870
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:32 → 108
    SM-ATX; Ataxin 2 SM domain

  15. XM_030242527.1 → XP_030098387.1  ataxin-2-like protein isoform X17

    Conserved Domains (2) summary
    PHA03247
    Location:3 → 499
    PHA03247; large tegument protein UL36; Provisional
    PRK14971
    Location:427 → 502
    PRK14971; DNA polymerase III subunit gamma/tau

  16. XM_017322209.2 → XP_017177698.1  ataxin-2-like protein isoform X13

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (4) summary
    PHA03247
    Location:281 → 826
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:142 → 204
    LsmAD; LsmAD domain
    pfam09770
    Location:635 → 836
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

  17. XM_030242526.2 → XP_030098386.1  ataxin-2-like protein isoform X16

    UniProtKB/TrEMBL
    E9Q5Q0
    Related
    ENSMUSP00000125881.3, ENSMUST00000166682.9
    Conserved Domains (4) summary
    PHA03247
    Location:214 → 820
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:142 → 204
    LsmAD; LsmAD domain
    pfam09770
    Location:710 → 915
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

  18. XM_030242524.1 → XP_030098384.1  ataxin-2-like protein isoform X14

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (4) summary
    PHA03247
    Location:214 → 820
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:142 → 204
    LsmAD; LsmAD domain
    pfam09770
    Location:629 → 830
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:1 → 74
    SM-ATX; Ataxin 2 SM domain

  19. XM_030242523.2 → XP_030098383.1  ataxin-2-like protein isoform X12

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (4) summary
    PHA03247
    Location:248 → 854
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:176 → 238
    LsmAD; LsmAD domain
    pfam09770
    Location:663 → 864
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:32 → 108
    SM-ATX; Ataxin 2 SM domain

  20. XM_030242517.1 → XP_030098377.1  ataxin-2-like protein isoform X7

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (4) summary
    PHA03247
    Location:277 → 883
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:205 → 267
    LsmAD; LsmAD domain
    pfam09770
    Location:692 → 893
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:61 → 137
    SM-ATX; Ataxin 2 SM domain

  21. XM_030242525.2 → XP_030098385.1  ataxin-2-like protein isoform X15

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (4) summary
    PHA03247
    Location:315 → 860
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:176 → 238
    LsmAD; LsmAD domain
    pfam09770
    Location:790 → 957
    PAT1; Topoisomerase II-associated protein PAT1
    pfam14438
    Location:32 → 108
    SM-ATX; Ataxin 2 SM domain

  22. XM_036153013.1 → XP_036008906.1  ataxin-2-like protein isoform X6

    UniProtKB/TrEMBL
    E9Q5Q0
    Conserved Domains (3) summary
    PHA03247
    Location:344 → 889
    PHA03247; large tegument protein UL36; Provisional
    pfam06741
    Location:205 → 267
    LsmAD; LsmAD domain
    pfam14438
    Location:64 → 137
    SM-ATX; Ataxin 2 SM domain

  23. XM_036153015.1 → XP_036008908.1  ataxin-2-like protein isoform X17

    Conserved Domains (2) summary
    PHA03247
    Location:3 → 499
    PHA03247; large tegument protein UL36; Provisional
    PRK14971
    Location:427 → 502
    PRK14971; DNA polymerase III subunit gamma/tau
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQH0.1 GenPept UniProtKB/Swiss-Prot:Q7TQH0

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