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Mosmo modulator of smoothened [ Mus musculus (house mouse) ]

Gene ID: 233812, updated on 11-Apr-2024

Summary

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Official Symbol
Mosmoprovided by MGI
Official Full Name
modulator of smoothenedprovided by MGI
Primary source
MGI:MGI:2446240
See related
Ensembl:ENSMUSG00000046096 AllianceGenome:MGI:2446240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atthog
Summary
Involved in negative regulation of smoothened signaling pathway; regulation of neuron differentiation; and regulation of protein stability. Located in Golgi apparatus and ciliary membrane. Orthologous to human MOSMO (modulator of smoothened). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 5.6), CNS E11.5 (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F2; 7 64.9 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120276814..120334079)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120677620..120734854)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32916 Neighboring gene mitochondrial import receptor subunit TOM7 homolog pseudogene Neighboring gene ubiquinol cytochrome c reductase core protein 2 Neighboring gene PDZ domain containing 9 Neighboring gene predicted gene, 57518 Neighboring gene von Willebrand factor A domain containing 3A Neighboring gene short chain dehydrogenase/reductase family 42E, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, et al. Dev Cell, 2018 Jan 8. PMID 29290584, Free PMC Article
  2. Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. Kong JH, et al. Development, 2021 Oct 1. PMID 34486668, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.
    Title: Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.
  2. This gene encodes a four-pass transmembrane protein that dampens signaling through the Hedgehog pathway by reducing the levels of the Smoothened oncoprotein at the cell surface and the primary cilium.
    Title: CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC40669

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within left/right pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in ciliary membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
modulator of smoothened protein
Names
Attenuator of Hedgehog
uncharacterized protein C16orf52 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164580.2 → NP_001158052.1  modulator of smoothened protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001158052.1

    Status: VALIDATED

    Source sequence(s)
    AC099930, AC122214
    Consensus CDS
    CCDS52381.1
    UniProtKB/Swiss-Prot
    Q3TS22, Q8C784, Q8K0V1
    Related
    ENSMUSP00000055934.7, ENSMUST00000060175.8
    Conserved Domains (1) summary
    pfam18800
    Location:25 → 166
    Atthog; Attenuator of Hedgehog

  2. NM_001420475.1 → NP_001407404.1  modulator of smoothened protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC099930, AC122214

  3. NM_001420476.1 → NP_001407405.1  modulator of smoothened protein isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC099930, AC122214

  4. NM_001420477.1 → NP_001407406.1  modulator of smoothened protein isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC099930, AC122214
    UniProtKB/TrEMBL
    A0A140LH99

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    120276814..120334079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C784.2 GenPept UniProtKB/Swiss-Prot:Q8C784

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