Abca16 ATP-binding cassette, sub-family A member 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abca16provided by MGI
Official Full Name: ATP-binding cassette, sub-family A member 16provided by MGI
Primary source: MGI:MGI:2388711
See related: Ensembl:ENSMUSG00000051900 AllianceGenome:MGI:2388711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in testis. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 8.6) See more
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Genomic context

Location:: 7 F2; 7 64.86 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (120008870..120144115)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (120409647..120544892)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

Abca16 (e-PCR), detects polymorphism
- UniSTS:279419

45.MMHAP88FLG6.seq (e-PCR)
- UniSTS:159682

AW208992 (e-PCR)
- UniSTS:207348

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-binding cassette transporter sub-family A member 16

Names: ATP-binding cassette, sub-family A (ABC1), member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278943.1 → NP_001265872.1 ATP-binding cassette transporter sub-family A member 16 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (isoform 1). The exon combination is inferred based on transcript alignments and protein homology.

Source sequence(s)

AC134434

Conserved Domains (3) summary

cd03263
Location:164 → 381

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

COG1131
Location:1001 → 1310

CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]

pfam12698
Location:652 → 885

ABC2_membrane_3; ABC-2 family transporter protein
NM_001278944.1 → NP_001265873.1 ATP-binding cassette transporter sub-family A member 16 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, and uses a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC134434

Conserved Domains (3) summary

cd03263
Location:76 → 294

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

COG1131
Location:914 → 1223

CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]

pfam12698
Location:565 → 798

ABC2_membrane_3; ABC-2 family transporter protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

120008870..120144115

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507683.2 → XP_006507746.1 ATP-binding cassette transporter sub-family A member 16 isoform X1

UniProtKB/TrEMBL

E9PWJ7

Related

ENSMUSP00000112736.2, ENSMUST00000120490.8

Conserved Domains (1) summary

TIGR01257
Location:196 → 1665

rim_protein; retinal-specific rim ABC transporter