U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cnga4 cyclic nucleotide gated channel alpha 4 [ Mus musculus (house mouse) ]

Gene ID: 233649, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Cnga4provided by MGI
Official Full Name
cyclic nucleotide gated channel alpha 4provided by MGI
Primary source
MGI:MGI:2664099
See related
Ensembl:ENSMUSG00000030897 AllianceGenome:MGI:2664099
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cGMP binding activity; intracellular cAMP-activated cation channel activity; and intracellular cGMP-activated cation channel activity. Acts upstream of or within sensory perception of smell. Predicted to be located in perikaryon and plasma membrane. Predicted to be part of intracellular cyclic nucleotide activated cation channel complex. Orthologous to human CNGA4 (cyclic nucleotide gated channel subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.1), cortex adult (RPKM 0.4) and 3 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 E3; 7 55.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105049247..105057981)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105400024..105408775)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene predicted gene 5901 Neighboring gene STARR-positive B cell enhancer ABC_E4960 Neighboring gene STARR-positive B cell enhancer ABC_E3739 Neighboring gene predicted gene 4972 Neighboring gene cholecystokinin B receptor

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Munger SD, et al. Science, 2001 Dec 7. PMID 11739959, Free PMC Article
  2. Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. Kelliher KR, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12649326, Free PMC Article
  3. Nomenclature for ion channel subunits. Bradley J, et al. Science, 2001 Dec 7. PMID 11764791, Free PMC Article
  4. cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation. Cisneros-Mejorado A, et al. FEBS Lett, 2012 Jan 20. PMID 22192355
  5. The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry. Zhong H, et al. Nature, 2002 Nov 14. PMID 12432397, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC130316

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cGMP binding ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly cAMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly cAMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly cGMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly cGMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of intracellular cyclic nucleotide activated cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intracellular cyclic nucleotide activated cation channel complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cyclic nucleotide-gated cation channel alpha-4
Names
CNG channel alpha-4
CNG-4
CNG4
cyclic nucleotide gated cation channel
olfactory cyclic nucleotide-gated channel

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033317.3 → NP_001028489.1  cyclic nucleotide-gated cation channel alpha-4

    See identical proteins and their annotated locations for NP_001028489.1

    Status: PROVISIONAL

    Source sequence(s)
    AC125055
    Consensus CDS
    CCDS21650.1
    UniProtKB/Swiss-Prot
    Q08EL1, Q3UW12
    Related
    ENSMUSP00000033187.5, ENSMUST00000033187.6
    Conserved Domains (3) summary
    cd00038
    Location:348 → 464
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:34 → 273
    Ion_trans; Ion transport protein
    pfam16526
    Location:464 → 534
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    105049247..105057981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322183.3 → XP_017177672.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

    UniProtKB/Swiss-Prot
    Q08EL1, Q3UW12
    Conserved Domains (3) summary
    cd00038
    Location:348 → 464
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:34 → 273
    Ion_trans; Ion transport protein
    pfam16526
    Location:464 → 534
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

  2. XM_030242497.2 → XP_030098357.1  cyclic nucleotide-gated cation channel alpha-4 isoform X2

    Related
    ENSMUSP00000147387.2, ENSMUST00000210344.2
    Conserved Domains (3) summary
    PLN03192
    Location:2 → 361
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00038
    Location:245 → 361
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam16526
    Location:361 → 431
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UW12.1 GenPept UniProtKB/Swiss-Prot:Q3UW12

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous