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Emsy EMSY, BRCA2-interacting transcriptional repressor [ Mus musculus (house mouse) ]

Gene ID: 233545, updated on 5-Mar-2024

Summary

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Official Symbol
Emsyprovided by MGI
Official Full Name
EMSY, BRCA2-interacting transcriptional repressorprovided by MGI
Primary source
MGI:MGI:1924203
See related
Ensembl:ENSMUSG00000035401 AllianceGenome:MGI:1924203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2210018M11Rik; 2310016L09Rik
Summary
Enables identical protein binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within DNA repair and chromatin organization. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human EMSY (EMSY transcriptional repressor, BRCA2 interacting). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.9), CNS E14 (RPKM 5.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Emsy in Genome Data Viewer
Location:
7 E1; 7 53.86 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (98236344..98308779, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (98587130..98656827, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33394 Neighboring gene predicted gene, 23040 Neighboring gene STARR-positive B cell enhancer mm9_chr7:105682961-105683262 Neighboring gene STARR-seq mESC enhancer starr_19631 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:105711530-105711812 Neighboring gene STARR-positive B cell enhancer ABC_E10453 Neighboring gene STARR-positive B cell enhancer mm9_chr7:105737605-105737906 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:105805164-105805273 Neighboring gene STARR-positive B cell enhancer mm9_chr7:105842676-105842977 Neighboring gene predicted gene 15506 Neighboring gene STARR-positive B cell enhancer ABC_E2833 Neighboring gene predicted gene, 57488 Neighboring gene THAP domain containing 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion. Marzio A, et al. Cell, 2022 Jan 6. PMID 34963055, Free PMC Article
  2. The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. Ezell SA, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22315412, Free PMC Article
  3. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Hughes-Davies L, et al. Cell, 2003 Nov 26. PMID 14651845
  4. Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69. Ekblad CM, et al. EMBO Rep, 2005 Jul. PMID 15947784, Free PMC Article
  5. O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry. Vosseller K, et al. Mol Cell Proteomics, 2006 May. PMID 16452088

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.
    Title: EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.
  2. Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY
    Title: The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC101920

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BRCA2-interacting transcriptional repressor EMSY
Names
protein EMSY

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381867.1 → NP_001368796.1  BRCA2-interacting transcriptional repressor EMSY isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC111124
    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    PRK10263
    Location:922 → 1098
    PRK10263; DNA translocase FtsK; Provisional
    pfam03735
    Location:19 → 85
    ENT; ENT domain

  2. NM_001381868.1 → NP_001368797.1  BRCA2-interacting transcriptional repressor EMSY isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC111124
    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    PRK10263
    Location:897 → 1073
    PRK10263; DNA translocase FtsK; Provisional
    pfam03735
    Location:19 → 59
    ENT; ENT domain

  3. NM_001381869.1 → NP_001368798.1  BRCA2-interacting transcriptional repressor EMSY isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC111124
    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    pfam03154
    Location:904 → 1106
    Atrophin-1; Atrophin-1 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  4. NM_001381870.1 → NP_001368799.1  BRCA2-interacting transcriptional repressor EMSY isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC111124
    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 85
    ENT; ENT domain

  5. NM_172280.2 → NP_758484.2  BRCA2-interacting transcriptional repressor EMSY isoform 4

    See identical proteins and their annotated locations for NP_758484.2

    Status: VALIDATED

    Source sequence(s)
    BC089304
    Consensus CDS
    CCDS40028.1
    UniProtKB/Swiss-Prot
    Q5FWK5, Q80XU1, Q8BMB0, Q8VDW9
    UniProtKB/TrEMBL
    A0A0U1RPK1
    Related
    ENSMUSP00000145858.2, ENSMUST00000205276.2
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    98236344..98308779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152990.1 → XP_036008883.1  BRCA2-interacting transcriptional repressor EMSY isoform X33

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 59
    ENT; ENT domain

  2. XM_036152991.1 → XP_036008884.1  BRCA2-interacting transcriptional repressor EMSY isoform X35

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 85
    ENT; ENT domain

  3. XM_017322180.3 → XP_017177669.1  BRCA2-interacting transcriptional repressor EMSY isoform X34

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:793 → 932
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  4. XM_036152989.1 → XP_036008882.1  BRCA2-interacting transcriptional repressor EMSY isoform X31

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  5. XM_036152988.1 → XP_036008881.1  BRCA2-interacting transcriptional repressor EMSY isoform X28

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (1) summary
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  6. XM_006507630.5 → XP_006507693.1  BRCA2-interacting transcriptional repressor EMSY isoform X25

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Related
    ENSMUSP00000038216.6, ENSMUST00000038359.6
    Conserved Domains (2) summary
    TIGR01628
    Location:914 → 1053
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  7. XM_017322179.3 → XP_017177668.1  BRCA2-interacting transcriptional repressor EMSY isoform X32

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:844 → 983
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  8. XM_017322178.3 → XP_017177667.1  BRCA2-interacting transcriptional repressor EMSY isoform X30

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:896 → 1035
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  9. XM_030242484.2 → XP_030098344.1  BRCA2-interacting transcriptional repressor EMSY isoform X29

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:899 → 1038
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  10. XM_017322176.3 → XP_017177665.1  BRCA2-interacting transcriptional repressor EMSY isoform X23

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:951 → 1090
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  11. XM_006507629.5 → XP_006507692.1  BRCA2-interacting transcriptional repressor EMSY isoform X21

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:965 → 1104
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  12. XM_006507615.5 → XP_006507678.1  BRCA2-interacting transcriptional repressor EMSY isoform X1

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:965 → 1108
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  13. XM_011241736.4 → XP_011240038.1  BRCA2-interacting transcriptional repressor EMSY isoform X19

    Conserved Domains (1) summary
    TIGR01628
    Location:837 → 980
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

  14. XM_006507631.5 → XP_006507694.1  BRCA2-interacting transcriptional repressor EMSY isoform X26

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Related
    ENSMUSP00000146011.2, ENSMUST00000205911.2
    Conserved Domains (2) summary
    TIGR01628
    Location:754 → 897
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 59
    ENT; ENT domain

  15. XM_006507627.5 → XP_006507690.1  BRCA2-interacting transcriptional repressor EMSY isoform X14

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:875 → 1018
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 59
    ENT; ENT domain

  16. XM_006507620.5 → XP_006507683.1  BRCA2-interacting transcriptional repressor EMSY isoform X6

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:926 → 1069
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 59
    ENT; ENT domain

  17. XM_030242482.2 → XP_030098342.1  BRCA2-interacting transcriptional repressor EMSY isoform X15

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:850 → 993
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 83
    ENT; ENT domain

  18. XM_036152986.1 → XP_036008879.1  BRCA2-interacting transcriptional repressor EMSY isoform X24

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    PRK10263
    Location:815 → 991
    PRK10263; DNA translocase FtsK; Provisional
    pfam03735
    Location:19 → 85
    ENT; ENT domain

  19. XM_017322174.3 → XP_017177663.1  BRCA2-interacting transcriptional repressor EMSY isoform X20

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:831 → 974
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 83
    ENT; ENT domain

  20. XM_036152985.1 → XP_036008878.1  BRCA2-interacting transcriptional repressor EMSY isoform X17

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    PRK10263
    Location:881 → 1057
    PRK10263; DNA translocase FtsK; Provisional
    pfam03735
    Location:19 → 85
    ENT; ENT domain

  21. XM_006507624.5 → XP_006507687.1  BRCA2-interacting transcriptional repressor EMSY isoform X11

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:900 → 1043
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 83
    ENT; ENT domain

  22. XM_006507619.5 → XP_006507682.1  BRCA2-interacting transcriptional repressor EMSY isoform X5

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:950 → 1093
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 83
    ENT; ENT domain

  23. XM_006507618.5 → XP_006507681.1  BRCA2-interacting transcriptional repressor EMSY isoform X4

    See identical proteins and their annotated locations for XP_006507681.1

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:951 → 1094
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 83
    ENT; ENT domain

  24. XM_036152987.1 → XP_036008880.1  BRCA2-interacting transcriptional repressor EMSY isoform X27

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    pfam03154
    Location:733 → 935
    Atrophin-1; Atrophin-1 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  25. XM_017322175.3 → XP_017177664.1  BRCA2-interacting transcriptional repressor EMSY isoform X22

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:793 → 936
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  26. XM_030242483.2 → XP_030098343.1  BRCA2-interacting transcriptional repressor EMSY isoform X16

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:845 → 988
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  27. XM_006507622.5 → XP_006507685.1  BRCA2-interacting transcriptional repressor EMSY isoform X8

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:914 → 1057
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  28. XM_006507616.5 → XP_006507679.1  BRCA2-interacting transcriptional repressor EMSY isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:964 → 1107
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  29. XM_036152984.1 → XP_036008877.1  BRCA2-interacting transcriptional repressor EMSY isoform X10

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    PRK10263
    Location:937 → 1113
    PRK10263; DNA translocase FtsK; Provisional
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  30. XM_006507621.5 → XP_006507684.1  BRCA2-interacting transcriptional repressor EMSY isoform X7

    Conserved Domains (2) summary
    TIGR01628
    Location:915 → 1058
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  31. XM_006507628.5 → XP_006507691.1  BRCA2-interacting transcriptional repressor EMSY isoform X18

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:844 → 987
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  32. XM_006507626.5 → XP_006507689.1  BRCA2-interacting transcriptional repressor EMSY isoform X13

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:896 → 1039
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  33. XM_006507623.5 → XP_006507686.1  BRCA2-interacting transcriptional repressor EMSY isoform X9

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:910 → 1053
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  34. XM_006507625.5 → XP_006507688.1  BRCA2-interacting transcriptional repressor EMSY isoform X12

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:899 → 1042
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

  35. XM_006507617.5 → XP_006507680.1  BRCA2-interacting transcriptional repressor EMSY isoform X3

    UniProtKB/TrEMBL
    A0A0U1RPK1
    Conserved Domains (2) summary
    TIGR01628
    Location:951 → 1094
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam03735
    Location:19 → 81
    ENT; ENT domain

RNA

  1. XR_004934080.1 RNA Sequence

  2. XR_004934082.1 RNA Sequence

  3. XR_004934081.1 RNA Sequence

  4. XR_001785533.3 RNA Sequence

  5. XR_003946459.2 RNA Sequence

  6. XR_001785534.3 RNA Sequence

  7. XR_001785532.3 RNA Sequence

  8. XR_378234.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMB0.2 GenPept UniProtKB/Swiss-Prot:Q8BMB0

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