Rsf1 remodeling and spacing factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rsf1provided by MGI
Official Full Name: remodeling and spacing factor 1provided by MGI
Primary source: MGI:MGI:2682305
See related: Ensembl:ENSMUSG00000035623 AllianceGenome:MGI:2682305
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: XAP8; p325; Gm164; Hbxap; 4832420A03Rik; C030033M12Rik
Summary: Predicted to enable histone binding activity and transcription coregulator activity. Predicted to be involved in several processes, including chromatin assembly; positive regulation of viral transcription; and regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Predicted to be part of RSF complex. Is expressed in several structures, including ear; genitourinary system; and nervous system. Orthologous to human RSF1 (remodeling and spacing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 4.7), CNS E14 (RPKM 4.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 53.55 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (97229103..97341989)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (97579870..97692782)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these data identify RSF1 as a H2Aub reader that contributes to H2Aub-mediated gene silencing by maintaining a stable nucleosome pattern at promoter regions.
Title: Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing.
Small interfering RNAs have specific inhibition of Hbxap expression and transactivation.
Title: Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c-myc by small interfering RNAs.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH118309 (e-PCR)
- UniSTS:160953

NoName (e-PCR)
- UniSTS:224186

NoName (e-PCR)
- UniSTS:235716

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone octamer slider activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RSF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RSF complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: remodeling and spacing factor 1

Names: hepatitis B virus x associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081267.2 → NP_001074736.1 remodeling and spacing factor 1

Status: VALIDATED

Source sequence(s)

AC124541, AC149605, AC151477

Consensus CDS

CCDS40025.1

UniProtKB/TrEMBL

E9PWW9

Related

ENSMUSP00000102771.3, ENSMUST00000107153.3

Conserved Domains (4) summary

cd15543
Location:896 → 941

PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)

pfam15612
Location:103 → 153

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:155 → 187

WHIM2; WSTF, HB1, Itc1p, MBD9 motif 2

cl02608
Location:918 → 971

BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...