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Crebzf CREB/ATF bZIP transcription factor [ Mus musculus (house mouse) ]

Gene ID: 233490, updated on 22-Apr-2024

Summary

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Official Symbol
Crebzfprovided by MGI
Official Full Name
CREB/ATF bZIP transcription factorprovided by MGI
Primary source
MGI:MGI:2675296
See related
Ensembl:ENSMUSG00000051451 AllianceGenome:MGI:2675296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zf; LAZip; SMILE; LAZipII; 1110034C16Rik; 6330417B10Rik
Summary
Predicted to enable identical protein binding activity and transcription cis-regulatory region binding activity. Predicted to be involved in regulation of transcription, DNA-templated and response to virus. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in nucleus. Is expressed in eye; foot mesenchyme; and nervous system. Orthologous to human CREBZF (CREB/ATF bZIP transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 27.9), ovary adult (RPKM 27.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E1; 7 50.59 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (90091942..90097590)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (90442734..90448382)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 2 Neighboring gene STARR-seq mESC enhancer starr_19508 Neighboring gene STARR-seq mESC enhancer starr_19509 Neighboring gene STARR-seq mESC enhancer starr_19510 Neighboring gene STARR-seq mESC enhancer starr_19511 Neighboring gene coiled-coil domain containing 89 Neighboring gene STARR-positive B cell enhancer ABC_E10450 Neighboring gene transmembrane protein 126A Neighboring gene STARR-positive B cell enhancer ABC_E352 Neighboring gene transmembrane protein 126B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation. Jhun J, et al. Cell Commun Signal, 2023 May 4. PMID 37143079, Free PMC Article
  2. [Biological functions of CREB/ATF bZIP transcription factor in metabolism and cell growth]. Liu YX, et al. Sheng Li Xue Bao, 2021 Oct 25. PMID 34708233
  3. Activation of CREBZF Increases Cell Apoptosis in Mouse Ovarian Granulosa Cells by Regulating the ERK1/2 and mTOR Signaling Pathways. Chen F, et al. Int J Mol Sci, 2018 Nov 8. PMID 30413092, Free PMC Article
  4. Small heterodimer partner-interacting leucine zipper protein inhibits adipogenesis by regulating peroxisome proliferator-activated receptor γ activity. Jang H, et al. Life Sci, 2015 Jul 1. PMID 25896661
  5. CREBZF expression and hormonal regulation in the mouse uterus. Lin P, et al. Reprod Biol Endocrinol, 2013 Dec 10. PMID 24325733, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate Insulin Resistance and Type 2 Diabetes.
    Title: Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate Insulin Resistance and Type 2 Diabetes.
  2. Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
    Title: Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
  3. Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation.
    Title: Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation.
  4. [Biological functions of CREB/ATF bZIP transcription factor in metabolism and cell growth].
    Title: [Biological functions of CREB/ATF bZIP transcription factor in metabolism and cell growth].
  5. Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY.
    Title: Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY.
  6. CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice.
    Title: CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice.
  7. these results suggest that CREBZF might play a proapoptotic role in cell apoptosis in granulosa cells, possibly by regulating the ERK1/2 and mTOR signaling pathways
    Title: Activation of CREBZF Increases Cell Apoptosis in Mouse Ovarian Granulosa Cells by Regulating the ERK1/2 and mTOR Signaling Pathways.
  8. SMILE is an insulin-inducible corepressor that suppresses hepatic gluconeogenesis.
    Title: Insulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis.
  9. Small heterodimer partner-interacting leucine zipper protein inhibits adipogenesis by regulating peroxisome proliferator-activated receptor gamma activity.
    Title: Small heterodimer partner-interacting leucine zipper protein inhibits adipogenesis by regulating peroxisome proliferator-activated receptor γ activity.
  10. Taken together, these findings demonstrate that SMILE negatively regulates osteocalcin via a direct interaction with RUNX2
    Title: SMILE inhibits BMP-2-induced expression of osteocalcin by suppressing the activity of the RUNX2 transcription factor in MC3T3E1 cells.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CREB/ATF bZIP transcription factor
Names
HCF-binding transcription factor Zhangfei
host cell factor-binding transcription factor Zhangfei
tyrosine kinase-associated leucine zipper protein LAZip
tyrosine kinase-associated leucine zipper protein LAZipII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145151.3 → NP_660133.2  CREB/ATF bZIP transcription factor

    See identical proteins and their annotated locations for NP_660133.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AC100322, AK004085
    Consensus CDS
    CCDS40020.1
    UniProtKB/Swiss-Prot
    Q91Y72, Q91ZR3
    Related
    ENSMUSP00000050972.6, ENSMUST00000061767.5
    Conserved Domains (1) summary
    cl21462
    Location:223 → 264
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RNA

  1. NR_073436.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC100322, AK004085, BI990274

  2. NR_073437.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC100322, CX237465

  3. NR_073438.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA028814, AC100322, BG094109

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    90091942..90097590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507606.2 → XP_006507669.1  CREB/ATF bZIP transcription factor isoform X1

    See identical proteins and their annotated locations for XP_006507669.1

    UniProtKB/Swiss-Prot
    Q91Y72, Q91ZR3
    Conserved Domains (1) summary
    cl21462
    Location:223 → 264
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZR3.2 GenPept UniProtKB/Swiss-Prot:Q91ZR3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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