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DOCK9 dedicator of cytokinesis 9 [ Homo sapiens (human) ]

Gene ID: 23348, updated on 7-Apr-2024

Summary

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Official Symbol
DOCK9provided by HGNC
Official Full Name
dedicator of cytokinesis 9provided by HGNC
Primary source
HGNC:HGNC:14132
See related
Ensembl:ENSG00000088387 MIM:607325; AllianceGenome:HGNC:14132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIZ1; ZIZIMIN1
Summary
Enables cadherin binding activity. Predicted to be involved in positive regulation of GTPase activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 21.7), thyroid (RPKM 20.1) and 23 other tissues See more
Orthologs
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Genomic context

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See DOCK9 in Genome Data Viewer
Location:
13q32.3
Exon count:
63
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (98793429..99088619, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (98003332..98298312, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99445683..99738948, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5461 Neighboring gene solute carrier family 15 member 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:99390337-99390879 Neighboring gene uncharacterized LOC105370330 Neighboring gene Sharpr-MPRA regulatory region 1899 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:99437954-99439153 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:99459441-99460640 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:99473100-99473600 Neighboring gene DOCK9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7923 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:99553940-99555139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99582088-99582640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99582641-99583193 Neighboring gene RPL7L1 pseudogene 12 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:99644283-99645482 Neighboring gene NANOG hESC enhancer GRCh37_chr13:99646324-99646825 Neighboring gene RNA, U6 small nuclear 83, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:99719017-99720216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5462 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:99738979-99739540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5465 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:99740103-99740662 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:99752082-99752247 Neighboring gene DOCK9 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5467 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_33558 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:99811198-99812397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:99824919-99825420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:99833707-99834219 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 22 Neighboring gene ribosomal protein S6 pseudogene 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Variant c.2262A>C in DOCK9 Leads to Exon Skipping in Keratoconus Family. Karolak JA, et al. Invest Ophthalmol Vis Sci, 2015 Dec. PMID 26641546
  2. Snapshots form a big picture of guanine nucleotide exchange. Rittinger K. Sci Signal, 2009 Oct 6. PMID 19809089
  3. Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Yang J, et al. Science, 2009 Sep 11. PMID 19745154
  4. Function of the N-terminus of zizimin1: autoinhibition and membrane targeting. Meller N, et al. Biochem J, 2008 Jan 15. PMID 17935486, Free PMC Article
  5. Sequence variation in DOCK9 and heterogeneity in bipolar disorder. Detera-Wadleigh SD, et al. Psychiatr Genet, 2007 Oct. PMID 17728666

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.
    Title: Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.
  2. c.2262A>C substitution in DOCK9 leads to a splicing aberration. However, because the mutation effect was observed in vitro, a definitive relationship between DOCK9 and KTCN phenotype could not be established.
    Title: Variant c.2262A>C in DOCK9 Leads to Exon Skipping in Keratoconus Family.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. Studies indicate that that many of the mechanistic principles of the exchange process are conserved in the DOCK9-catalyzed reaction.
    Title: Snapshots form a big picture of guanine nucleotide exchange.
  5. through structural analysis of DOCK9-Cdc42 complexes, we identify a nucleotide sensor within the alpha10 helix of the DHR2 domain that contributes to release of guanine diphosphate (GDP) and then to discharge of the activated GTP-bound Cdc42
    Title: Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
  6. interaction between Smad2/3 and the Cdc42 guanine nucleotide exchange factor, Zizimin1, in response to TGF-beta1
    Title: Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1.
  7. DOCK2 and DOCK9 specifically recognize Rac2 and Cdc42 through their switch 1 as well as beta2-beta3 regions and the mode of recognition via switch 1 appears to be conserved among diverse Rac-specific DHR-2 GEFs
    Title: Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Sequence variation in DOCK9 and heterogeneity in bipolar disorder.
  9. novel functions for the N-terminal region of zizimin1.
    Title: Function of the N-terminus of zizimin1: autoinhibition and membrane targeting.
  10. DOCK9 contributes to both risk and increased illness severity in bipolar disorder.
    Title: Sequence variation in DOCK9 and heterogeneity in bipolar disorder.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11949, FLJ16744, FLJ44528, FLJ45282, FLJ45601, KIAA1058, KIAA1085, DKFZp686D2047, DKFZp686C11110, DKFZp686N04132

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
dedicator of cytokinesis protein 9
Names
cdc42 guanine nucleotide exchange factor zizimin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130048.2 → NP_001123520.1  dedicator of cytokinesis protein 9 isoform b

    See identical proteins and their annotated locations for NP_001123520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) has a distinct N-terminus that is 1 aa shorter than that of isoform a.
    Source sequence(s)
    AB028981, AK127215, AL161420, BC043506, BM968821, DB277756
    Consensus CDS
    CCDS45062.1
    UniProtKB/TrEMBL
    A0A2X0SYY4
    Related
    ENSP00000365643.1, ENST00000376460.5
    Conserved Domains (5) summary
    cd08697
    Location:638 → 827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1611 → 2062
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:169 → 292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:174 → 279
    PH; PH domain
    pfam11878
    Location:62 → 153
    DUF3398; Domain of unknown function (DUF3398)

  2. NM_001130049.2 → NP_001123521.1  dedicator of cytokinesis protein 9 isoform c

    See identical proteins and their annotated locations for NP_001123521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and lacks several exons in the 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AF527605, AL391122, AW450751, BC146814
    Consensus CDS
    CCDS76645.1
    UniProtKB/TrEMBL
    A0A0A0MT38, A6H8Z6
    Related
    ENSP00000413781.2, ENST00000427887.2
    Conserved Domains (4) summary
    cd08697
    Location:639 → 828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:170 → 293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:175 → 280
    PH; PH domain
    pfam11878
    Location:63 → 154
    DUF3398; Domain of unknown function (DUF3398)

  3. NM_001130050.2 → NP_001123522.1  dedicator of cytokinesis protein 9 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 5' coding region, and 3' UTR, and lacks several exons in the 3' coding region, compared to variant 1. The resulting isoform (d) has distinct N- and C-termini, and is shorter than isoform a.
    Source sequence(s)
    AB028981, AK126492, AW450751
    Consensus CDS
    CCDS45063.1
    UniProtKB/TrEMBL
    A6H8Z6
    Related
    ENSP00000487551.1, ENST00000627024.2
    Conserved Domains (4) summary
    cd08697
    Location:638 → 827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:169 → 292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:174 → 279
    PH; PH domain
    pfam11878
    Location:62 → 153
    DUF3398; Domain of unknown function (DUF3398)

  4. NM_001318849.2 → NP_001305778.1  dedicator of cytokinesis protein 9 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (e) is shorter than isoform a.
    Source sequence(s)
    AF527605, AK294705, AL161420, AL391122, BC136274, BX648707
    UniProtKB/TrEMBL
    B7ZVX0, B9EG73
    Conserved Domains (4) summary
    cd08697
    Location:639 → 828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1612 → 2040
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:170 → 293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:46 → 156
    DUF3398; Domain of unknown function (DUF3398)

  5. NM_001366676.2 → NP_001353605.1  dedicator of cytokinesis protein 9 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL139084, AL161420
    UniProtKB/TrEMBL
    A0A8V8TQS9
    Related
    ENSP00000515237.1, ENST00000703210.1
    Conserved Domains (4) summary
    cd08697
    Location:650 → 839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1623 → 2051
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:181 → 304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:74 → 165
    DUF3398; Domain of unknown function (DUF3398)

  6. NM_001366677.2 → NP_001353606.1  dedicator of cytokinesis protein 9 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL139084, AL161420
    UniProtKB/TrEMBL
    A0A088AWN3
    Conserved Domains (4) summary
    cd08697
    Location:650 → 839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1615 → 2041
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:181 → 304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:74 → 165
    DUF3398; Domain of unknown function (DUF3398)

  7. NM_001366678.2 → NP_001353607.1  dedicator of cytokinesis protein 9 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL139084, AL161420
    UniProtKB/TrEMBL
    A0A8V8TR95
    Related
    ENSP00000515238.1, ENST00000703211.1
    Conserved Domains (4) summary
    cd08697
    Location:650 → 839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1623 → 2074
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:181 → 304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:74 → 165
    DUF3398; Domain of unknown function (DUF3398)

  8. NM_001366679.2 → NP_001353608.1  dedicator of cytokinesis protein 9 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL139084, AL161420
    UniProtKB/TrEMBL
    A0A2X0SYY4
    Conserved Domains (4) summary
    cd08697
    Location:638 → 827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1603 → 2029
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:169 → 292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:62 → 153
    DUF3398; Domain of unknown function (DUF3398)

  9. NM_001366680.2 → NP_001353609.1  dedicator of cytokinesis protein 9 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL139084, AL161420
    Consensus CDS
    CCDS91827.1
    UniProtKB/TrEMBL
    A0A2X0SYY4, X6RGR3
    Related
    ENSP00000403528.2, ENST00000449796.6
    Conserved Domains (4) summary
    cd08697
    Location:638 → 827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1603 → 2017
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:169 → 292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:62 → 153
    DUF3398; Domain of unknown function (DUF3398)

  10. NM_001366681.2 → NP_001353610.1  dedicator of cytokinesis protein 9 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL139084, AL161420
    UniProtKB/TrEMBL
    A0A2X0SYY4
    Conserved Domains (4) summary
    cd08697
    Location:638 → 827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1634 → 2083
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:169 → 292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:62 → 153
    DUF3398; Domain of unknown function (DUF3398)

  11. NM_001366682.2 → NP_001353611.1  dedicator of cytokinesis protein 9 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL139084, AL161420
    UniProtKB/TrEMBL
    A0A2X0SYY4
    Conserved Domains (4) summary
    cd08697
    Location:638 → 827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1634 → 2060
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:169 → 292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:62 → 153
    DUF3398; Domain of unknown function (DUF3398)

  12. NM_001366683.2 → NP_001353612.1  dedicator of cytokinesis protein 9 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL139084, AL161420
    Consensus CDS
    CCDS91828.1
    UniProtKB/TrEMBL
    A0A2X0SYY4, A0A804HIE8
    Related
    ENSP00000507034.1, ENST00000682017.1
    Conserved Domains (4) summary
    cd08697
    Location:638 → 827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1634 → 2048
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:169 → 292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:62 → 153
    DUF3398; Domain of unknown function (DUF3398)

  13. NM_001366684.2 → NP_001353613.1  dedicator of cytokinesis protein 9 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL139084, AL161420
    UniProtKB/TrEMBL
    A0A2X0SYY4
    Conserved Domains (4) summary
    cd08697
    Location:638 → 827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1634 → 2071
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:169 → 292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:62 → 153
    DUF3398; Domain of unknown function (DUF3398)

  14. NM_015296.3 → NP_056111.1  dedicator of cytokinesis protein 9 isoform a

    See identical proteins and their annotated locations for NP_056111.1

    Status: VALIDATED

    Source sequence(s)
    AF527605, AK127215, AL161420, AL391122, BC043506, BM968821
    Consensus CDS
    CCDS91829.1
    UniProtKB/Swiss-Prot
    B3KX25, E9PFM9, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9BZ29, Q9UPU4
    UniProtKB/TrEMBL
    B7ZVX0
    Related
    ENSP00000498761.1, ENST00000652315.1
    Conserved Domains (5) summary
    cd08697
    Location:639 → 828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1612 → 2063
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:170 → 293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:175 → 280
    PH; PH domain
    pfam11878
    Location:63 → 154
    DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    98793429..99088619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430231.1 → XP_047286187.1  dedicator of cytokinesis protein 9 isoform X12

  2. XM_005254035.4 → XP_005254092.1  dedicator of cytokinesis protein 9 isoform X27

    UniProtKB/TrEMBL
    B7ZVX0
    Conserved Domains (5) summary
    cd08697
    Location:639 → 828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1604 → 2018
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:170 → 293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:175 → 280
    PH; PH domain
    pfam11878
    Location:63 → 154
    DUF3398; Domain of unknown function (DUF3398)

  3. XM_006719937.4 → XP_006720000.1  dedicator of cytokinesis protein 9 isoform X25

    UniProtKB/TrEMBL
    B7ZVX0
    Conserved Domains (5) summary
    cd08697
    Location:639 → 828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1612 → 2040
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:170 → 293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:175 → 280
    PH; PH domain
    pfam11878
    Location:63 → 154
    DUF3398; Domain of unknown function (DUF3398)

  4. XM_047430235.1 → XP_047286191.1  dedicator of cytokinesis protein 9 isoform X22

  5. XM_006719931.4 → XP_006719994.1  dedicator of cytokinesis protein 9 isoform X17

    See identical proteins and their annotated locations for XP_006719994.1

    UniProtKB/TrEMBL
    B7ZVX0
    Conserved Domains (5) summary
    cd08697
    Location:639 → 828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1612 → 2063
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:170 → 293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:175 → 280
    PH; PH domain
    pfam11878
    Location:63 → 154
    DUF3398; Domain of unknown function (DUF3398)

  6. XM_005254034.4 → XP_005254091.1  dedicator of cytokinesis protein 9 isoform X21

    UniProtKB/TrEMBL
    B7ZVX0
    Conserved Domains (5) summary
    cd08697
    Location:639 → 828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1635 → 2049
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:170 → 293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:175 → 280
    PH; PH domain
    pfam11878
    Location:63 → 154
    DUF3398; Domain of unknown function (DUF3398)

  7. XM_047430234.1 → XP_047286190.1  dedicator of cytokinesis protein 9 isoform X15

  8. XM_006719924.3 → XP_006719987.1  dedicator of cytokinesis protein 9 isoform X9

    UniProtKB/TrEMBL
    B7ZVX0
    Conserved Domains (5) summary
    cd08697
    Location:639 → 828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1635 → 2086
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:170 → 293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:175 → 280
    PH; PH domain
    pfam11878
    Location:63 → 154
    DUF3398; Domain of unknown function (DUF3398)

  9. XM_006719936.2 → XP_006719999.1  dedicator of cytokinesis protein 9 isoform X20

    UniProtKB/TrEMBL
    A0A088AWN3
    Related
    ENSP00000401958.4, ENST00000448493.7
    Conserved Domains (5) summary
    cd08697
    Location:650 → 839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1623 → 2051
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:181 → 304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:186 → 291
    PH; PH domain
    pfam11878
    Location:74 → 165
    DUF3398; Domain of unknown function (DUF3398)

  10. XM_047430232.1 → XP_047286188.1  dedicator of cytokinesis protein 9 isoform X13

  11. XM_006719922.2 → XP_006719985.1  dedicator of cytokinesis protein 9 isoform X5

    UniProtKB/TrEMBL
    A0A088AWN3
    Conserved Domains (5) summary
    cd08697
    Location:650 → 839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1646 → 2097
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:181 → 304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:186 → 291
    PH; PH domain
    pfam11878
    Location:74 → 165
    DUF3398; Domain of unknown function (DUF3398)

  12. XM_017020513.2 → XP_016876002.1  dedicator of cytokinesis protein 9 isoform X16

    UniProtKB/TrEMBL
    A0A8V8TRI9

  13. XM_017020510.2 → XP_016875999.1  dedicator of cytokinesis protein 9 isoform X11

    UniProtKB/TrEMBL
    A0A8V8TRI9

  14. XM_017020508.2 → XP_016875997.1  dedicator of cytokinesis protein 9 isoform X8

    UniProtKB/TrEMBL
    A0A8V8TRI9

  15. XM_017020506.2 → XP_016875995.1  dedicator of cytokinesis protein 9 isoform X4

    UniProtKB/TrEMBL
    A0A8V8TRI9

  16. XM_017020511.2 → XP_016876000.1  dedicator of cytokinesis protein 9 isoform X14

    UniProtKB/TrEMBL
    A0A8V8TRI9

  17. XM_047430230.1 → XP_047286186.1  dedicator of cytokinesis protein 9 isoform X7

  18. XM_017020507.2 → XP_016875996.1  dedicator of cytokinesis protein 9 isoform X6

    UniProtKB/TrEMBL
    A0A8V8TRI9

  19. XM_017020505.2 → XP_016875994.1  dedicator of cytokinesis protein 9 isoform X3

    UniProtKB/TrEMBL
    A0A8V8TRI9

  20. XM_017020504.2 → XP_016875993.1  dedicator of cytokinesis protein 9 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TRI9

  21. XM_017020503.2 → XP_016875992.1  dedicator of cytokinesis protein 9 isoform X1

    UniProtKB/TrEMBL
    A0A8V8TRI9

  22. XM_047430237.1 → XP_047286193.1  dedicator of cytokinesis protein 9 isoform X24

  23. XM_017020515.2 → XP_016876004.1  dedicator of cytokinesis protein 9 isoform X19

    UniProtKB/TrEMBL
    A0A2X0SYY4

  24. XM_047430238.1 → XP_047286194.1  dedicator of cytokinesis protein 9 isoform X26

  25. XM_047430236.1 → XP_047286192.1  dedicator of cytokinesis protein 9 isoform X23

  26. XM_006719932.2 → XP_006719995.1  dedicator of cytokinesis protein 9 isoform X18

    UniProtKB/TrEMBL
    A0A2X0SYY4
    Conserved Domains (5) summary
    cd08697
    Location:638 → 827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1611 → 2062
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:169 → 292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:174 → 279
    PH; PH domain
    pfam11878
    Location:62 → 153
    DUF3398; Domain of unknown function (DUF3398)

  27. XM_006719925.2 → XP_006719988.1  dedicator of cytokinesis protein 9 isoform X10

    UniProtKB/TrEMBL
    A0A2X0SYY4
    Conserved Domains (5) summary
    cd08697
    Location:638 → 827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:1634 → 2085
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    cd13267
    Location:169 → 292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:174 → 279
    PH; PH domain
    pfam11878
    Location:62 → 153
    DUF3398; Domain of unknown function (DUF3398)

  28. XM_047430240.1 → XP_047286196.1  dedicator of cytokinesis protein 9 isoform X29

    Related
    ENSP00000515240.1, ENST00000703216.1

  29. XM_047430239.1 → XP_047286195.1  dedicator of cytokinesis protein 9 isoform X28

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    98003332..98298312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374362.1 → XP_054230337.1  dedicator of cytokinesis protein 9 isoform X12

  2. XM_054374377.1 → XP_054230352.1  dedicator of cytokinesis protein 9 isoform X27

  3. XM_054374375.1 → XP_054230350.1  dedicator of cytokinesis protein 9 isoform X25

  4. XM_054374372.1 → XP_054230347.1  dedicator of cytokinesis protein 9 isoform X22

  5. XM_054374367.1 → XP_054230342.1  dedicator of cytokinesis protein 9 isoform X17

  6. XM_054374371.1 → XP_054230346.1  dedicator of cytokinesis protein 9 isoform X21

  7. XM_054374365.1 → XP_054230340.1  dedicator of cytokinesis protein 9 isoform X15

  8. XM_054374359.1 → XP_054230334.1  dedicator of cytokinesis protein 9 isoform X9

  9. XM_054374370.1 → XP_054230345.1  dedicator of cytokinesis protein 9 isoform X20

  10. XM_054374363.1 → XP_054230338.1  dedicator of cytokinesis protein 9 isoform X13

  11. XM_054374355.1 → XP_054230330.1  dedicator of cytokinesis protein 9 isoform X5

  12. XM_054374366.1 → XP_054230341.1  dedicator of cytokinesis protein 9 isoform X16

  13. XM_054374361.1 → XP_054230336.1  dedicator of cytokinesis protein 9 isoform X11

  14. XM_054374358.1 → XP_054230333.1  dedicator of cytokinesis protein 9 isoform X8

  15. XM_054374354.1 → XP_054230329.1  dedicator of cytokinesis protein 9 isoform X4

  16. XM_054374364.1 → XP_054230339.1  dedicator of cytokinesis protein 9 isoform X14

  17. XM_054374357.1 → XP_054230332.1  dedicator of cytokinesis protein 9 isoform X7

  18. XM_054374356.1 → XP_054230331.1  dedicator of cytokinesis protein 9 isoform X6

  19. XM_054374353.1 → XP_054230328.1  dedicator of cytokinesis protein 9 isoform X3

  20. XM_054374352.1 → XP_054230327.1  dedicator of cytokinesis protein 9 isoform X2

  21. XM_054374351.1 → XP_054230326.1  dedicator of cytokinesis protein 9 isoform X1

  22. XM_054374374.1 → XP_054230349.1  dedicator of cytokinesis protein 9 isoform X24

  23. XM_054374369.1 → XP_054230344.1  dedicator of cytokinesis protein 9 isoform X19

  24. XM_054374376.1 → XP_054230351.1  dedicator of cytokinesis protein 9 isoform X26

  25. XM_054374373.1 → XP_054230348.1  dedicator of cytokinesis protein 9 isoform X23

  26. XM_054374368.1 → XP_054230343.1  dedicator of cytokinesis protein 9 isoform X18

  27. XM_054374360.1 → XP_054230335.1  dedicator of cytokinesis protein 9 isoform X10

  28. XM_054374378.1 → XP_054230353.1  dedicator of cytokinesis protein 9 isoform X28

  29. XM_054374379.1 → XP_054230354.1  dedicator of cytokinesis protein 9 isoform X29

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BZ29.2 GenPept UniProtKB/Swiss-Prot:Q9BZ29

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